See all 19642 hotels in Historic Route 66
- Hyatt Regency O'Hare Chicago
- Hilton Garden Inn Chicago Downtown South Loop
- Courtyard by Marriott Chicago Magnificent Mile
- L7 Chicago by LOTTE
- Hotel Saint Clair- Magnificent Mile
- The Royal Sonesta Chicago River North
- Holiday Inn Chicago SW-Countryside ConfCtr by IHG
- Travelodge by Wyndham Downtown Chicago
- Trump International Hotel & Tower Chicago
- The Godfrey Hotel Chicago
- Freehand Chicago
- SureStay Plus Hotel by Best Western Chicago Lombard
- The Langham, Chicago
- Embassy Suites by Hilton Chicago Downtown Magnificent Mile
- Bluegreen Vacations Hotel Blake, an Ascend Collection Hotel
- Sofitel Chicago Magnificent Mile
- Red Roof Inn Chicago-O'Hare Airport/ Arlington Hts
- GreenTree Inn Flagstaff
- Hampton Inn Chicago Downtown/Magnificent Mile
- Best Western Grant Park Hotel
- Arlo Chicago
- River Spirit Casino Resort
- Holiday Inn & Suites Chicago - Downtown by IHG
- FOUND Hotel Chicago River North
- Tropicana Laughlin - A Caesars Rewards Destination
- Hyatt Regency St. Louis at The Arch
- Loews Chicago O'Hare Hotel
- Holiday Inn Chicago North-Evanston by IHG
- Hampton Inn Chicago-O'Hare International Airport
- Hilton St. Louis Airport
- Golden Nugget Laughlin
- Don Laughlin's Riverside Resort Hotel & Casino
- Kinzie Hotel
- Thompson Chicago, by Hyatt
- Hyatt Centric Chicago Magnificent Mile
- Avi Resort & Casino
- DoubleTree by Hilton Chicago - Arlington Heights
- Virgin Hotels Chicago
- Hotel Aspen InnSuites Flagstaff/Grand Canyon
- Comfort Inn & Suites Arlington Heights - Schaumburg
- Hyatt Place Chicago/O'Hare Airport
- Hilton Garden Inn Chicago Central Loop
- Sonesta Simply Suites Chicago O'Hare Airport