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21C Museum Hotel St Louis

4.5 star property

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Restaurant
Massages
A modern lobby with a large glass sphere, seating areas, and a reception desk.
Bar (on property)
Exterior

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning
The current price is $173
$148 nightly
$173 total
Total with taxes and fees
Jul 19 - Jul 20

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪20 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(115 reviews)
  • 309 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Luxury Double Room, 2 Queen Beds

A hotel room with two beds, a large window, a modern ceiling light, and a view of a staircase.

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(36 reviews)
  • 423 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Room (Bunk Bed)

A hotel room with a bunk bed, a round table with a chair, a potted plant, and a colorful abstract painting on the wall.

Room (Bunk Bed)

8.4 out of 10
Very good
(7 reviews)
  • 237 sq ft
  • Sleeps 2
  • 1 Twin Bunk Bed
  • Free WiFi

View all photos for Loft, 2 Queen Beds

A hotel room with two beds, a large padded headboard, a flat-screen TV, a window with a city view, and a small side table with a plant.

Loft, 2 Queen Beds

9.0 out of 10
Wonderful
(2 reviews)
  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 269 sq ft
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Suite, 1 King Bed (21C)

A hotel room with a large bed, a desk, a chair, a nightstand, and a mirror.

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (Library)

  • City view
  • 732 sq ft
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout drapes

Luxury Suite, 1 King Bed

9.4 out of 10
Exceptional
(3 reviews)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Deluxe Room, 1 Double Bed, Accessible

A hotel room with two beds, a sofa, a TV, and a large abstract painting.

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed
  • Free WiFi

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed
  • Free WiFi

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Lobby
Hyatt Regency St. Louis at The Arch
Downtown St. Louis
  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
4.3 out of 5, Excellent, 4,120 reviews
$143 nightly
The price is $169
Jun 28 - Jun 29
Total with taxes and fees
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About the neighborhood

St. Louis

A stay at 21C Museum Hotel St Louis places you in the heart of St. Louis, within a 10-minute walk of St. Louis Union Station and City Museum. .This luxury hotel is 0.4 mi (0.7 km) from Enterprise Center and 0.7 mi (1.1 km) from America's Center Convention Complex.

What's nearby

  • Washington Avenue Historic District - 2 min walk - 0.1 miles
  • City Museum - 5 min walk - 0.3 miles
  • St. Louis Union Station - 8 min walk - 0.4 miles
  • Enterprise Center - 8 min walk - 0.5 miles
  • St. Louis Aquarium at Union Station - 11 min walk - 0.6 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 24 min drive

Restaurants

  • ‪Imo's Pizza Headquarters & Retail Store - ‬7 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk
  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪Medina Grill - ‬5 min walk

About this property

21C Museum Hotel St Louis

21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.
Make yourself at home in one of the 104 air-conditioned rooms featuring espresso makers and flat-screen televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have complimentary toiletries and hair dryers. Conveniences include phones, as well as safes and desks.
Don't miss out on the many recreational opportunities, including an indoor pool, a steam room, and a fitness center. Additional amenities at this hotel include complimentary wireless internet access, concierge services, and a banquet hall.
Enjoy a meal at the restaurant or snacks in the coffee shop/cafe. The hotel also offers room service (during limited hours). Wrap up your day with a drink at the bar/lounge. Cooked-to-order breakfasts are available daily from 6:30 AM to 1:00 PM for a fee.
Featured amenities include a business center, dry cleaning/laundry services, and a 24-hour front desk.
Cooked-to-order breakfasts are available for a surcharge and are served each morning between 6:30 AM and 1:00 PM.
21C Museum Hotel St Louis has a restaurant on site.
Room service (during limited hours) is available.

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 100 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs only

Children and extra beds

Children are welcome
Rollaway/extra beds are not available
Cribs (infant beds) are not available

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1351 out of 1916 reviews
Rating 8 - Good. 292 out of 1916 reviews
Rating 6 - Okay. 139 out of 1916 reviews
Rating 4 - Poor. 62 out of 1916 reviews
Rating 2 - Terrible. 72 out of 1916 reviews

9.2/10

Cleanliness

9.0/10

Staff & service

9.0/10

Amenities

9.2/10

Property conditions & facilities

Reviews

Verified

10/10 Excellent

Michael

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful hotel!
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Amanda

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Absolutely beautiful, amazing breakfast, comfy bed!
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Chad

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
A fantastic stay. Great breakfast and excellent pool area. Would stay again
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Mike

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful place, friendly staff! Enjoyed our stay and will definitely come back!!!
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Malisa

Liked: Cleanliness, staff & service, property conditions & facilities
It is a nice hotel
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Eric

Liked: Cleanliness, amenities, property conditions & facilities
Great place to stay. I recommend it and will stay again.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Tim

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Stay was great and the hotel was a close walk to Enterprise Center.
Stayed 1 night in Mar 2026
Verified

8/10 Good

Kevin

Liked: Cleanliness, staff & service, property conditions & facilities
Unique hotel, would stay again
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Kelly

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We had a great stay at the Museum hotel! Place was gorgeous, room very clean & the staff was wonderful! Highly recommend!
Stayed 3 nights in Mar 2026
Verified

10/10 Excellent

Darrell

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This is the ONLY hotel that we stay at when we come to St. Louis!
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Alex

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great staff!!
Stayed 1 night in Mar 2026
Verified

8/10 Good

Kristen

Liked: Cleanliness, staff & service, amenities
Friendly staff, beautiful atmosphere, modern finishes.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Barry

Liked: Cleanliness, amenities, property conditions & facilities
Great atmosphere, excellent room accommodations. Staff at the Idlewolf restaurant inside the hotel were great, and the happy hour is excellent for the modest price. Will be staying again soon!
Stayed 3 nights in Feb 2026
Verified

10/10 Excellent

Hanna

Liked: Cleanliness, staff & service, amenities
The one of the best hotels in stl
Stayed 2 nights in Oct 2025
Verified

10/10 Excellent

Kimbriel

Liked: Cleanliness, amenities, property conditions & facilities
Everything was great i can’t wait to stay again
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Robert

Liked: Cleanliness, amenities, property conditions & facilities
Great service. Would definitely stay again
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

LaVias

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great hotel. Hip bar with great food. Great dtink menu. Also stellar fitness area with quality swimming pool, sauna, and steam room. This place ia a diamond in the rough.
Stayed 3 nights in Mar 2026
Verified

8/10 Good

Valerie

Liked: Staff & service, amenities
Nice room, the hot tub and steam room were fantastic. The staff were friendly and it was convenient to have coffee right downstairs.
Stayed 4 nights in Feb 2026
Verified

10/10 Excellent

anthony

Liked: Cleanliness, amenities, property conditions & facilities
Clean room and the hotel itself is just gorgeous.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Vesta

Liked: Cleanliness
From the time we arrived, we loved the vibe of 21C! Our stay exceeded or expectations! Upon visiting the area again, we will stay at 21C. Convenient to downtown venues and eateries, walkable to different exhibit a museums.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Linda

Liked: Cleanliness, amenities, property conditions & facilities
Beautiful, unique hotel. Loved the esthetics and vibe of the entire building.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

steven h

Liked: Cleanliness, staff & service, property conditions & facilities
Such a cool hotel I love the museum on the second floor so interesting and all the penguins food is great restaurants great everything just what a great stay very unique but very quiet very cozy love everything about it. Can’t wait to stay at the other ones.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Tanya

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
So fun and eclectic! !
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Jill

Liked: Cleanliness, staff & service, property conditions & facilities
Great lock
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Dimitre

Liked: Cleanliness, amenities, property conditions & facilities
Great hotel! Art, food and drinks were fantastic
Stayed 1 night in Jan 2026