See all 746 hotels in Southwest Illinois
- Days Inn by Wyndham Troy IL
- Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake
- TownePlace Suites by Marriott St. Louis Edwardsville
- Fairfield Inn by Marriott St. Louis Collinsville
- Super 8 by Wyndham Greenville
- SureStay Hotel by Best Western Greenville
- Hotel 7 Inn Anna
- Laketree Inn And Suites Marion
- Country Garden & Suites
- Americas Best Value Inn West Frankfort
- Super 8 by Wyndham Du Quoin
- Bel Air Motel
- Super 8 by Wyndham Waterloo
- Innkeeper Motel
- Loyalty Inn Maryville
- Red Bud Country Inn
- Wine Country Farmhouse On the Wine 🍷 Trail! Private Lake kayaks Fire Pit 🔥
- Budget Motel Granite City/St Louis Area
- ECONOMY INN
- First Western Inn Caseyville
- Super 8 by Wyndham Salem
- Powhatan Motel
- Motel 6 Troy, IL
- Americas Best Value Inn Vandalia
- Budget Inn by Hotel O Greensville I 70
- Briarwood Inn of Sparta
- Lighthouse Lodge
- Makanda Inn
- The Conner House B&B
- Eagles Crossing is a Newly Renovated 3-Bed Farmhouse with a Large Deck & Hot Tub
- centralia motel
- Americas Best Value Inn Marion, IL
- Royal Inn
- Capital O Sparta Motel Near Carbondale
- Americas Best Value Inn Mount Vernon
- Quality Inn Cairo I-57
- Trailway Motel
- Hidden in a Private Wooded Area
- The Turkey Farmhouse just a few minutes from Rend Lake
- Private country setting. just 10 minutes from town
- Modern Queen Suite Near SIU Carbondale
- Modern 2BR Lake Suite • Dock & Firepit
- Comfort Inn & Suites Ofallon - St Louis Area
- Corner George Inn Bed & Breakfast
- Stunning 8-bedroom barndo on a 24-acre farm with pond, located on wine trail
- Lakeside Luxury, Screened in Porch, Fountain View
- Family retreat! Comfortable Country Farmhouse 5 minutes south of Sparta.
- Giant City Lodge
- Nanny's Place- Cozy Porchview Getaway B&B by Shawnee Hills Wine Trail and Parks
- Charming pet friendly bed & breakfast with Washer/Dryer and King size Bed
- Charming farmhouse on a beautiful horse ranch-Shawnee Hills Wine Trail
- Mariner's Village Resort
- Beautiful Cabin Retreat
- Marion Gray Plaza Motel
- Mount Vernon Hotel and Event Center
- Nanny's Place- Cozy Rustic Getaway B&B by Shawnee Hills Wine Trail and Parks
- Carbondale Value Inn & Suites
- Gray Plaza Motel
- Charming 2-bedroom lodge with WiFi, AC, quietly tucked away in the woods.
- Sunset Motel
- Baymont by Wyndham Highland
- Red Bud Country Inn
- 10 minutes from downtown St. Louis Convenient location off I-64
- Charming 4-bedroom farmhouse!
- Little Dipper Retreat - Woods - WiFi - Hot Tub
- Pear Tree Inn St. Louis Near Union Station
- Drury Plaza Hotel St. Louis at the Arch
- 21C Museum Hotel St Louis
- Hyatt Regency St. Louis at The Arch
- Hollywood Casino & Hotel St. Louis
- River City Casino & Hotel
- Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
- Drury Inn & Suites St. Louis Union Station
- Pear Tree Inn St. Louis Airport
- Live by Loews - St.Louis
- Hilton St. Louis Airport
- Renaissance St. Louis Airport Hotel
- Best Western St. Louis-Kirkwood Route 66
- Home2 Suites by Hilton St. Louis Downtown
- Hotel Indigo St Louis - Central West End by IHG
- Marriott St. Louis Grand
- Magnolia Hotel St. Louis, a Tribute Portfolio Hotel