See all 746 hotels in Southwest Illinois
- Baymont by Wyndham Litchfield
- TownePlace Suites by Marriott Brentwood
- Courtyard St. Louis Airport/Earth City
- Super 8 by Wyndham St. Louis North
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
- Candlewood Suites Cape Girardeau by IHG
- Holiday Inn St. Louis Arpt West-Earth City by IHG
- Best Western Plus Parkway Hotel
- Drury Inn & Suites St. Louis Arnold
- Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
- Courtyard by Marriott St. Louis West County
- Guest Host Motel
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Quality Inn Cape Girardeau North
- Extended Stay America Suites St Louis Westport Central
- Courtyard by Marriott Cape Girardeau Downtown
- Holiday Inn Express and Suites Alton St Louis Area by IHG
- Hampton Inn & Suites St. Louis/Alton
- Comfort Inn Alton near I-255
- Fairfield Inn & Suites by Marriott Cape Girardeau
- SpringHill Suites by Marriott St. Louis Airport/Earth City
- Quality Inn Florissant - St Louis
- Embassy Suites by Hilton St. Louis Airport
- HomeTowne Studios by Red Roof St. Louis - Airport/ N Lindbergh
- Red Roof Inn St Louis - Westport/ Maryland Heights
- Best Western Plus Sikeston I-55
- Comfort Inn Festus - St Louis South
- The Lodge at Grant's Trail
- Americas Best Value Inn St. Louis Downtown
- Fairfield Inn & Suites by Marriott St. Louis South
- Tru By Hilton Cape Girardeau
- Days Inn and Suites by Wyndham Sikeston
- Residence Inn By Marriott St. Louis Clayton
- Holiday Inn Express & Suites Perryville by IHG
- Microtel Inn & Suites by Wyndham Sainte Genevieve
- Comfort Inn & Suites Hazelwood - St. Louis
- Hampton Inn St. Louis/Westport
- Comfort Inn St. Louis Airport
- Baymont by Wyndham Festus
- Super 8 by Wyndham Metropolis
- Extended Stay America Select Suites - St. Louis - Airport - Central
- Super 8 by Wyndham St. Louis Airport
- Sheraton Westport Plaza Hotel St. Louis
- Hampton Inn Cape Girardeau I 55 East
- Economy Inn & Suites
- The Lodge Hotel and Banquets
- Comfort Suites Jackson-Cape Girardeau
- The Last Hotel
- Residence Inn by Marriott St. Louis West County
- Beautiful, Rehabbed Unit in Shaw Community 4228a
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
- Extended Stay America Select Suites - St. Louis - Westport - E Lackland Rd
- Extended Stay America Select Suites St Louis Earth City
- Amazing Soulard STL Unit, 713a
- Super 8 by Wyndham Staunton
- Country Yard Inn and Suite
- Super 8 by Wyndham Perryville
- Town House Inn Cape Giradreau
- Beautiful, Rehabbed Unit in Shaw Community - 4226b
- Cozy, Fun, and One-Of-A-Kind!
- Super 8 by Wyndham Sikeston/Miner Area
- Welcome Suites Hazelwood
- MainStay Suites St Louis Airport
- Ultramodern 2BR Corner Loft w/Designer Features
- Benton Park Inn
- Gorgeous Ultramodern 2BR Loft + Patio
- Sheraton Westport Chalet Hotel St. Louis
- Indoor Heated Pool pontoon boat fish 3 full baths sleeps 17 in beds 2026 SALE!!!
- Quality Inn Litchfield Route 66
- Super 8 by Wyndham Jerseyville
- The West End - Futon with Queen
- Entire building in The Grove, Perfect for Groups!
- Radisson Hotel St. Louis Downtown Convention Center
- Motel 6 Metropolis, IL
- STL, Tower Grove, 2-Story Townhome - B
- Hampton Inn by Hilton Litchfield
- Super 8 by Wyndham Pevely
- Residence Inn St Louis Westport
- Intown Suites Extended Stay St. Louis Mo - Hazelwood
- OYO Hotel St. Louis Downtown City Center MO
- Chic Ultramodern Loft Suite w/ Designer Features
- Super 8 by Wyndham Harrisburg
- Days Inn by Wyndham Perryville
- Hotel 7 Vienna
- Super 8 by Wyndham Charleston/Sikeston East MO