See all 423 hotels in De Soto
- Edgetowner Motel
- Ramada Tropics Resort & Conf Center by Wyndham Des Moines
- Sonesta Simply Suites Des Moines
- Stoney Creek Hotel Des Moines - Johnston
- Hyatt Place West Des Moines Jordan Creek
- Drury Inn & Suites West Des Moines
- Days Inn & Suites by Wyndham Des Moines Airport
- Fairfield Inn and Suites by Marriott Des Moines West
- Hampton Inn Des Moines-Airport
- Quality Inn & Suites Des Moines - Merle Hay Road
- Holiday Inn Express & Suites West Des Moines - Jordan Creek by IHG
- Homewood Suites by Hilton Des Moines Airport
- GrandStay Hotel & Suites
- Tru By Hilton Grimes Des Moines
- Sonesta Essential Des Moines
- La Quinta Inn & Suites by Wyndham Des Moines West Clive
- Revel Hotel Des Moines Urbandale, Tapestry Collection by Hilton
- Hotel Renovo Des Moines Urbandale,Tapestry Collection Hilton
- Hampton Inn & Suites West Des Moines/SW Mall Area
- Microtel Inn & Suites by Wyndham Urbandale/Des Moines
- Hampton Inn West Des Moines Lake Drive
- Days Inn by Wyndham West Des Moines / Clive
- Holiday Inn Des Moines-Airport/Conf Center by IHG
- MainStay Suites Waukee - West Des Moines
- Hilton Garden Inn Des Moines/Urbandale
- Super 8 by Wyndham Clive IA
- Comfort Inn & Suites West Des Moines
- Fairfield Inn & Suites by Marriott Des Moines Airport
- The Rewind West Des Moines, Tapestry Collection by Hilton
- Quality Inn
- TownePlace Suites by Marriott Des Moines West/Jordan Creek
- TownePlace Suites by Marriott - Des Moines Urbandale
- Best Western Plus Des Moines West Inn & Suites
- Cobblestone Inn & Suites - Winterset, IA
- Woodspring Suites West Des Moines
- Fairfield by Marriott Inn & Suites Norwalk
- Tru By Hilton Norwalk Des Moines
- AmericInn by Wyndham Stuart
- Homewood Suites By Hilton Urbandale Des Moines
- Extended Stay America Select Suites - Des Moines - West Des Moines
- Extended Stay America Select Suites - Des Moines - Urbandale
- Days Inn by Wyndham Des Moines Merle Hay
- 10-Acre Adventure Lodge w/River Valley View on 10 Acres - Cozy/Romantic/Family
- Hawthorne Hideaway is a Charming 3-bedrm bed & breakfast in West DSM with WiFi
- Menlo Farmhouse
- Charming 1855 Stone Farmhouse Retreat – Cozy Stays & Picturesque Views Await
- Entire farmhouse in the country