Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Lowest round trip fares by airline from Orlando and San Francisco

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Cheap flights from Orlando to San Francisco

Cheap flights from Orlando to San Francisco

Your flight from Orlando International Airport (MCO) to San Francisco International Airport (SFO), will bring you to the exciting City by the Bay. From Chinatown and the Castro, to Haight-Ashbury and Telegraph Hill, San Francisco is made up of exciting and varied neighborhoods. At SFO, renting a vehicle is a cinch. In a little more than an hour, you can take your rental car down to San Jose via Interstate 280.

Key Facts

In San Francisco, the only major interstate is I-280, which runs east to west. State Highway 101 runs through the city from north to south and connects to most of the major roadways. The observation deck at Coit Tower is a great place to view the city, from the wharf to the Golden Gate Bridge.

For some fresh air, you can visit Pier 39. After walking down the length of the pier and enjoying a little window shopping, you can visit the sea lions that enjoy catching some rays on the rocks nearby. You’ll also find some amazing views of the boats sailing by on the bay.

Hints and Tips

After boarding your airplane at the Orlando International Airport (MCO), you can expect to spend more than five hours in the air before arriving in San Francisco.

Packages from Orlando to San Francisco

Hotels in San Francisco

See all 807 Properties in San Francisco

Estimated price for 1 night/2 adults

Hotel Zoe Fisherman's Wharf

Hotel Zoe Fisherman's Wharf

425 North Point, San Francisco, CA
    4.0 out of 5.0
     
     
    3.8 out of 5 (25 reviews)

    Hotel Zoe Fisherman's Wharf is 2 blocks from Fisherman's Wharf, Pier 39, and the Alcatraz Island ferry.

    Hotel Zoe Fisherman's Wharf$193

    Jun 2 - Jun 3

    Hotel Zoe Fisherman's Wharf$193
    Hotel Zephyr

    Hotel Zephyr

    250 Beach Street, San Francisco, CA
      4.0 out of 5.0
       
       
      4.3 out of 5 (15 reviews)

      Located in North Beach, this boutique hotel is within a 5-minute walk of Ripley's Believe It Or Not Museum and Pier 39. San Francisco Bay and Ghirardelli Square ...

      Hotel Zephyr$135

      Jun 16 - Jun 17

      Hotel Zephyr$135
      Hotel Spero

      Hotel Spero

      405 Taylor St, San Francisco, CA
        4.0 out of 5.0
         
         
        4.8 out of 5 (4 reviews)

        Located in Downtown San Francisco, this romantic hotel is within a 15-minute walk of Powell and Market Cable Car Turnaround, Asian Art Museum of San Francisco, ...

        Hotel Spero$179

        May 26 - May 27

        Hotel Spero$179
        Pier 2620 Hotel Fisherman's Wharf

        Pier 2620 Hotel Fisherman's Wharf

        2620 Jones Street, San Francisco, CA
          4.0 out of 5.0
           
           
          4.4 out of 5 (38 reviews)

          Located in North Beach, this hotel is within a 10-minute walk of Fishermans Wharf Cable Car Turnaround, Hyde Street Pier, and Ghirardelli Square. Lombard Street ...

          San Francisco Marriott Marquis

          San Francisco Marriott Marquis

          780 Mission Street, San Francisco, CA
            4.0 out of 5.0
             
             
            4.3 out of 5 (33 reviews)

            The San Francisco Marriott Marquis is steps from Union Square shopping, Chinatown, cable cars, and the San Francisco Museum of Modern Art.

            San Francisco Marriott Marquis$179

            May 24 - May 25

            San Francisco Marriott Marquis$179
            Hyatt Regency San Francisco

            Hyatt Regency San Francisco

            5 Embarcadero Center, San Francisco, CA
              4.0 out of 5.0
               
               
              4.2 out of 5 (19 reviews)

              Located in Downtown San Francisco, this hotel is within 6 mi (10 km) of 555 California Street, San Francisco Bay, and Exploratorium. San Francisco Museum of ...

              Hyatt Regency San Francisco$152

              May 26 - May 27

              Hyatt Regency San Francisco$152
              La Quinta by Wyndham San Francisco Airport North

              La Quinta by Wyndham San Francisco Airport North

              20 Airport Blvd, South San Francisco, CA
                2.5 out of 5.0
                 
                 
                4.3 out of 5 (3 reviews)

                2 blocks from the South San Francisco Conference Center and 1 mile from the airport, this hotel offers complimentary airport transportation, and downtown San ...

                La Quinta by Wyndham San Francisco Airport North$119

                May 31 - Jun 1

                La Quinta by Wyndham San Francisco Airport North$119
                Hyatt Regency San Francisco Airport

                Hyatt Regency San Francisco Airport

                1333 Bayshore Hwy, Burlingame, CA
                  4.0 out of 5.0
                   
                   
                  4.3 out of 5 (24 reviews)

                  This family-friendly Burlingame hotel is located near the airport, within 1 mi (2 km) of Bayfront Park and San Francisco Bay. Millbrae Square Shopping Center ...

                  Hyatt Regency San Francisco Airport$97

                  May 27 - May 28

                  Hyatt Regency San Francisco Airport$97
                  Travelodge by Wyndham San Francisco Airport North

                  Travelodge by Wyndham San Francisco Airport North

                  326 S Airport Blvd, South San Francisco, CA
                    2.0 out of 5.0
                     
                     
                    2.8 out of 5 (86 reviews)

                    Situated near the airport, this motel is 1.7 mi (2.8 km) from San Francisco Bay and within 6 mi (10 km) of South San Francisco Convention Center and Millbrae ...

                    Travelodge by Wyndham San Francisco Airport North$74

                    May 27 - May 28

                    Travelodge by Wyndham San Francisco Airport North$74
                    Hotel Whitcomb

                    Hotel Whitcomb

                    1231 Market St, San Francisco, CA
                      3.5 out of 5.0
                       
                       
                      3.5 out of 5 (100 reviews)

                      Located in Downtown San Francisco, this historic hotel is within a 5-minute walk of Orpheum Theater, Bill Graham Civic Auditorium, and Asian Art Museum of San ...

                      Hotel Whitcomb$84

                      May 27 - May 28

                      Hotel Whitcomb$84
                      Map

                      *Savings based on all holiday package bookings with Flight + Hotel on CheapTickets.com from January through December 2017, as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages. For Free Flight or 100% Off Flight deals, package savings is greater than or equal to the current cost of one component, when both are priced separately.

                      Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other CheapTickets users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

                      Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $75 service fee charged by CheapTickets.

                      Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.