Cheap flights from Des Moines (DSM) to Panama City (PNS)

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Lowest round trip fares by airline from Des Moines and Panama City

Cheapest prices ($193 One Way, $199 Round Trip) found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Great Deals On Cheap Hotels in Panama City

Boardwalk Beach Hotel

Boardwalk Beach Hotel

2.5 out of 5
9600 S Thomas Dr, Panama City Beach, FL
The price is $87 per night from Apr 9 to Apr 10
$87
per night
Apr 9 - Apr 10
Stay at this beach hotel in Panama City Beach. Enjoy free parking, 2 outdoor pools, and 2 restaurants. Our guests praise the clean rooms and the overall value ...
5.8/10 (1,757 reviews)
"Needs updating which is in progress but still isn’t too bad. Beautiful layout, excellent service, and centrally located to all hot spots"

Reviewed on Mar 28, 2024

Boardwalk Beach Hotel
Casa Loma Inn

Casa Loma Inn

2 out of 5
13615 Front Beach Rd, Panama City Beach, FL
The price is $131 per night from Apr 28 to Apr 29
$131
per night
Apr 28 - Apr 29
Stay at this beach motel in Panama City Beach. Enjoy free WiFi, free parking, and a private beach. Our guests praise the pool and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,001 reviews)
Sweet little gem on the beach!
"Love the Casa Loma…smaller old school motel right on the beach. Up to date rooms, nice decor. Every room has ocean view. Swimming pool is saltwater and heated. Definitely coming back!!"

Reviewed on Mar 25, 2024

Casa Loma Inn
Ramada by Wyndham Panama City Beach / Beachfront

Ramada by Wyndham Panama City Beach / Beachfront

2 out of 5
15405 Front Beach Rd., Panama City Beach, FL
The price is $71 per night from Apr 7 to Apr 8
$71
per night
Apr 7 - Apr 8
Stay at this beach hotel in Panama City Beach. Enjoy free parking, a beach locale, and room service. Our guests praise the clean rooms and the overall value ...
5/10 (1,009 reviews)
You get what you pay for…
"This place only cost me $79 and I was there for only one night so I can’t complain too much… This place is in dire need of a remodel as well as some cleanliness. The toilet paper holder did not have the roller so the TP was sitting on a shelf. The roll only had a little left and there was no backup. ..."

Reviewed on Mar 20, 2024

Ramada by Wyndham Panama City Beach / Beachfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Fly From Des Moines to Panama City

Origin
Des Moines
Destination
Panama City
Number of Daily Flights
Earliest Flight Departure Date
Latest Flight Departure Date
Popular Airlines

Cheap flights from Des Moines to Panama City

Are you ready to book your flight, but feeling nervous about paying too much if prices drop in a few days? Don't play the waiting game. Our Best Price Guarantee means if you see a better fare for the same flight, we'll give you the difference in CheapCash, plus $50 more in CheapCash, which you can use to save on your hotel reservation.

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Save Even More Time and Money With a Panama City Travel Package

Once your flights are booked, why start all over again searching for a cheap hotel? Book your flight and hotel together, and save yourself more than time and energy. You'll also be able to take advantage of discounts and coupons on your Panama City vacation that you can't get when you book flights and hotel separately.

Relax in Panama City With Confidence and Convenience

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*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.