Cheap flights from Des Moines (DSM) to Panama City (PNS)

Get more for your budget and save up to 50% off select Secret Bargain hotels

Get even more value with CheapTickets Price Guarantee!

Change your flight without a fee on select flights

Lowest round trip fares by airline from Des Moines and Panama City

Cheapest prices ( One Way, $251 Round Trip) found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Great Deals On Cheap Hotels in Panama City

Boardwalk Beach Hotel

Boardwalk Beach Hotel

2.5 out of 5
9600 S Thomas Dr, Panama City Beach, FL, 32408
The price is $76 per night from Dec 21 to Dec 22
$76
per night
Dec 21 - Dec 22
Stay at this beach hotel in Panama City Beach. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the clean rooms and the overall value in ...
2.9/5 (1,912 reviews)
budget
"We stay here for the ease of our pet and the location. It is an older place but they trying to renovate slowly. Bathrooms are small and mattresses could be changed out but it provides nicely for us"

Reviewed on Nov 28, 2022

Boardwalk Beach Hotel
Casa Loma Inn

Casa Loma Inn

2 out of 5
13615 Front Beach Rd, Panama City Beach, FL, 32407
The price is $59 per night from Dec 4 to Dec 5
$59
per night
Dec 4 - Dec 5
Stay at this beach motel in Panama City Beach. Enjoy free WiFi, free parking, and a private beach. Our guests praise the helpful staff and the clean rooms in ...
3.9/5 Good! (1,000 reviews)
upgrade
"they need to upgrade the place especially the bathroom"

Reviewed on Nov 27, 2022

Casa Loma Inn
Ramada by Wyndham Panama City Beach / Beachfront

Ramada by Wyndham Panama City Beach / Beachfront

2 out of 5
15405 Front Beach Rd., Panama City Beach, FL, 32413
The price is $71 per night from Dec 6 to Dec 7
$71
per night
Dec 6 - Dec 7
Stay at this beach hotel in Panama City Beach. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the overall value in our reviews. Popular ...
2.7/5 (1,001 reviews)
"Loved the convenience to surrounding dining and activity options. Continental breakfast was lacking."

Reviewed on Oct 20, 2022

Ramada by Wyndham Panama City Beach / Beachfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Fly From Des Moines to Panama City

Origin Des Moines
Destination Panama City
Number of Daily Flights
Earliest Flight Departure Date
Latest Flight Departure Date
Popular Airlines

Cheap flights from Des Moines to Panama City

Are you ready to book your flight, but feeling nervous about paying too much if the price drops? Don't play the waiting game. Our Best Price Guarantee means if you see a better fare for the same flight, we'll give you the difference in CheapCash, plus a $50 CheapCash bonus, which you can use to save on your hotel reservation.

If you have a frequent flier account, add it to your reservation to earn miles. And don't worry about getting stuck in a middle seat. Choose your seats when you book, so you'll be right where you want to be on departure day.

Save Even More Time and Money With a Panama City Travel Package

Once your flights are booked, why start all over again searching for a cheap hotel? Book your flight and hotel together, and save yourself more than time and energy. You'll also be able to take advantage of discounts and coupons on your Panama City vacation that you can't get when you book flights and hotel separately.

Relax in Panama City With Confidence and Convenience

Going cheap doesn't mean giving up great service. Our agents are available 24/7 to help you find the right cheap flights and hotel, and to answer questions about your trip.

Need to grab a cheap travel deal while you're on the go? Download our mobile app, where you can search and book just like you would on your home computer. Stay in-the-know on great rates on flights from Des Moines to Panama City by signing up for exclusive email deals.

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.