Cheap flights from Des Moines (DSM) to San Francisco (SJC)

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Lowest round trip fares by airline from Des Moines and San Francisco

Cheapest prices ($70 One Way, $128 Round Trip) found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Great Deals On Cheap Hotels in San Francisco

Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North

2 out of 5
326 S Airport Blvd, South San Francisco, CA
The price is $52 per night from Sep 23 to Sep 23
Situated near the airport, this motel is within 9 mi (15 km) of Candlestick Point State Recreation Area, Pacifica State Beach, and Pacifica Pier. Mission Dolores ...
2.9/5 (8 reviews)
"Room was clean"

Reviewed on Jul 13, 2021

Travelodge by Wyndham San Francisco Airport North
Hotel North Beach

Hotel North Beach

2 out of 5
935 Kearny Street, San Francisco, CA
The price is $58 per night from Oct 8 to Oct 8
Located in Downtown San Francisco, this hotel is within a 10-minute walk of TransAmerica Pyramid, 555 California Street, and Embarcadero Center. Exploratorium ...
3.8/5Good! (12 reviews)
"I like that it's in the center of North Beach, close to everywhere, beautiful area. Revielle cafe across the street, Happy Donuts downstairs which is open 24/7"

Reviewed on Sep 6, 2019

Hotel North Beach
Super 8 by Wyndham San Bruno /SF Intl Arpt West

Super 8 by Wyndham San Bruno /SF Intl Arpt West

2.5 out of 5
421 El Camino Real, San Bruno, CA
The price is $95 per night from Sep 23 to Sep 23
Situated near the airport, this hotel is within 9 mi (15 km) of Poplar Creek Golf Course, Pacifica State Beach, and Pacifica Pier. Candlestick Point State Recreation ...
5/5Exceptional! (1 review)
"It was clean, the bed was comfortable and picked us up at the Airport"

Reviewed on Feb 12, 2019

Super 8 by Wyndham San Bruno /SF Intl Arpt West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Fly From Des Moines to San Francisco

Origin Des Moines
Destination San Francisco
Number of Daily Flights
Earliest Flight Departure Date
Latest Flight Departure Date
Popular Airlines

Cheap flights from Des Moines to San Francisco

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Save Even More Time and Money With a San Francisco Travel Package

Once your flights are booked, why start all over again searching for a cheap hotel? Book your flight and hotel together, and save yourself more than time and energy. You'll also be able to take advantage of discounts and coupons on your San Francisco vacation that you can't get when you book flights and hotel separately.

Relax in San Francisco With Confidence and Convenience

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*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.