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Lowest round trip fares by airline from St. Louis and San Francisco

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Cheap flights from St. Louis to San Francisco

Cheap flights from St Louis to San Francisco

Lambert - St Louis International Airport (STL) is about 10 miles northwest of downtown St. Louis and is serviced via major transportation routes I-70, I-270 and Highway 67.

Flight times from STL to San Francisco International Airport (SFO) are usually between four and seven hours and begin at 7 a.m. SFO is accessible via coastal Highway 101, and Highway 82 provides service westward to the interior.

Attractions and tips

No trip to San Francisco is complete without gazing upon the Golden Gate Bridge, a 1.7-mile span that is walkable and is considered one of the 7 Wonders of the Modern World. Alcatraz Island was a federal prison from 1934 through 1963 and housed Al Capone and Machine Gun Kelly.

Pier 39 is famous for its seafood and clam chowder, and it’s equally well-known views of the city and the bay. The Presidio is a national park site, which was once a military post, and now features recreational activities along with historic and architectural treasures. The Yerba Buena Gardens feature museums, public art, a children’s garden and an historic carousel.

San Francisco has relatively dry and warm - not hot - summers and mild winters, but its climate can be very unpredictable due to its proximity to the Pacific Ocean, San Francisco Bay and the Sierra Nevada Mountains coastal range. Expect a chilly, damp fog during May and June mornings and persistent overcast skies until afternoon.

Packages from St. Louis to San Francisco

San Francisco vacations with economy flights

Hotels in San Francisco

See all 1,098 Properties in San Francisco
Hotel Zephyr

Hotel Zephyr

250 Beach Street, San Francisco, CA
    4.0 out of 5.0
     
     
    4.3 out of 5 (18 reviews)

    Located in North Beach, this boutique hotel is within a 5-minute walk of Wax Museum at Fisherman's Wharf, Ripley's Believe It Or Not Museum, and Aquarium of ...

    Hotel Zephyr$157

    Hotel Zephyr$157
    Hotel Spero

    Hotel Spero

    405 Taylor St, San Francisco, CA
      4.0 out of 5.0
       
       
      4.7 out of 5 (6 reviews)

      Located in Downtown San Francisco, this romantic hotel is within a 15-minute walk of Powell and Market Cable Car Turnaround, Asian Art Museum of San Francisco, ...

      Hotel Spero$163

      Hotel Spero$163
      BEI Hotel San Francisco

      BEI Hotel San Francisco

      50 8th Street, San Francisco, CA
        3.5 out of 5.0
         
         
        3.0 out of 5 (4 reviews)

        Located in Downtown San Francisco, this hotel is within 1 mi (2 km) of Moscone Convention Center and San Francisco Museum of Modern Art. Oracle Park and Ghirardelli ...

        BEI Hotel San Francisco$125

        BEI Hotel San Francisco$125
        Hotel Whitcomb

        Hotel Whitcomb

        1231 Market St, San Francisco, CA
          3.5 out of 5.0
           
           
          3.5 out of 5 (107 reviews)

          Located in Downtown San Francisco, this historic hotel is within a 5-minute walk of Orpheum Theater, Asian Art Museum of San Francisco, and Bill Graham Civic ...

          Hotel Whitcomb$111

          Hotel Whitcomb$111
          Pullman San Francisco Bay

          Pullman San Francisco Bay

          223 Twin Dolphin Dr, Redwood City, CA
            4.0 out of 5.0
             
             
            4.2 out of 5 (14 reviews)

            Located in Redwood Shores, this romantic hotel is within 1 mi (2 km) of Marlin Park and Hiller Aviation Museum. Laurie Meadows Park and Los Prados Park are also ...

            Pullman San Francisco Bay$111

            Pullman San Francisco Bay$111
            Hotel Nikko San Francisco

            Hotel Nikko San Francisco

            222 Mason St, San Francisco, CA
              4.0 out of 5.0
               
               
              4.3 out of 5 (41 reviews)

              This family-friendly San Francisco hotel is located in the entertainment district, just steps from SHN Curran Theatre and Powell and Market Cable Car Turnaround. ...

              Hotel Nikko San Francisco$185

              Hotel Nikko San Francisco$185
              Fairmont San Francisco

              Fairmont San Francisco

              950 Mason Street Atop Nob Hill, San Francisco, CA
                5.0 out of 5.0
                 
                 
                3.9 out of 5 (17 reviews)

                This family-friendly San Francisco hotel is located in the historical district, within a 10-minute walk of Grace Cathedral and SHN Curran Theatre. TransAmerica ...

                Fairmont San Francisco$206

                Fairmont San Francisco$206
                Grand Hyatt San Francisco Union Square

                Grand Hyatt San Francisco Union Square

                345 Stockton St, San Francisco, CA
                  4.0 out of 5.0
                   
                   
                  3.9 out of 5 (26 reviews)

                  Located in Downtown San Francisco, this eco-friendly hotel is within a 10-minute walk of SHN Curran Theatre, Westfield San Francisco Centre, and San Francisco ...

                  Grand Hyatt San Francisco Union Square$169

                  Grand Hyatt San Francisco Union Square$169
                  Travelodge by Wyndham San Francisco Airport North

                  Travelodge by Wyndham San Francisco Airport North

                  326 S Airport Blvd, South San Francisco, CA
                    2.0 out of 5.0
                     
                     
                    2.8 out of 5 (86 reviews)

                    Located in The East Side, this motel is 0.2 mi (0.3 km) from South San Francisco Convention Center and within 6 mi (10 km) of Cow Palace and Millbrae Square ...

                    Travelodge by Wyndham San Francisco Airport North$67

                    Travelodge by Wyndham San Francisco Airport North$67
                    Hyatt Regency San Francisco

                    Hyatt Regency San Francisco

                    5 Embarcadero Center, San Francisco, CA
                      4.0 out of 5.0
                       
                       
                      4.2 out of 5 (22 reviews)

                      Located in Downtown San Francisco, this hotel is within a 10-minute walk of Ferry Building and Embarcadero Center. TransAmerica Pyramid and Exploratorium are ...

                      Hyatt Regency San Francisco$179

                      Hyatt Regency San Francisco$179
                      Map

                      *Savings based on all holiday package bookings with Flight + Hotel on CheapTickets.com from January through December 2017, as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages. For Free Flight or 100% Off Flight deals, package savings is greater than or equal to the current cost of one component, when both are priced separately.

                      *Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.