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Featured St. Charles Hotels with Air Conditioning

Home2 Suites by Hilton St. Charles St.Louis
32 Research Park Circle St. Charles MO
Located in St. Charles, Home2 Suites by Hilton St. Charles St.Louis is in the suburbs, a 1-minute drive from Missouri Bluffs Golf Course and 6 minutes from Weldon Spring Site Interpretive Center.
Pool
Hot Tub

Hampton Inn St. Charles St. Peters
3720 W Clay St St. Charles MO
$106 nightly
The price is $122 total per night
$122 total
Apr 12 - Apr 13
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
When you stay at Hampton Inn St. Charles St. Peters in St. Charles, you'll be next to a golf course, within a 10-minute drive of Ameristar Casino St. Charles and Hollywood Casino Amphitheatre.
Pool
Hot Tub

Americas Best Value Inn & Suites St. Louis, St. Charles Inn
1310 Bass Pro Drive St. Charles MO
$90 nightly
The price is $104 total per night
$104 total
Apr 7 - Apr 8
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
Located in St. Charles, Americas Best Value Inn & Suites St. Louis, St. Charles Inn is in the historical district, within a 5-minute drive of First Missouri State Capitol Historic Site and Lindenwood University.
Pool
Breakfast included

Ameristar Casino Resort and Spa
1 Ameristar Blvd St. Charles MO
$193 nightly
The price is $226 total per night
$226 total
Apr 7 - Apr 8
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
A stay at Ameristar Casino Resort and Spa places you in the heart of St. Charles, steps from Ameristar Casino St. Charles and a 4-minute drive from Family Arena.
Pool
Hot Tub

Best Western Plus The Charles Hotel
1425 South 5th Street St. Charles MO
When you stay at Best Western Plus The Charles Hotel in St. Charles, you'll be in the historical district, within a 5-minute drive of Ameristar Casino St. Charles and Hollywood Casino Amphitheatre.
Pool
Breakfast included

Comfort Suites St Charles - St Louis
1400 S 5th St St. Charles MO
$90 nightly
The price is $103 total per night
$103 total
May 3 - May 4
Total with taxes and fees
Free Cancellation
With a stay at Comfort Suites St Charles - St Louis, you'll be centrally located in St. Charles, a short 8-minute walk from Ameristar Casino St. Charles and 14 minutes by foot from Historic Main Street.
Pool
Breakfast included

Country Inn & Suites by Radisson, St. Charles Historic District
1190 S Main St St. Charles MO
$135 nightly
The price is $155 total per night
$155 total
May 3 - May 4
Total with taxes and fees
Free Cancellation
With a stay at Country Inn & Suites by Radisson, St. Charles Historic District in St. Charles (St. Charles Historic District), you'll be a 1-minute drive from Ameristar Casino St. Charles and 6 minutes from Hollywood Casino Amphitheatre.
Pool
Breakfast included

Drury Plaza Hotel St. Louis St. Charles
380 Mulholland Drive St. Charles MO
$132 nightly
The price is $153 total per night
$153 total
May 3 - May 4
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
When you stay at Drury Plaza Hotel St. Louis St. Charles in St. Charles, you'll be in the business district, within a 5-minute drive of Ameristar Casino St. Charles and Hollywood Casino Amphitheatre.
Pool
Hot Tub

Embassy Suites by Hilton St. Louis St. Charles
2 Convention Center Plz St. Charles MO
$130 nightly
The price is $150 total per night
$150 total
Apr 12 - Apr 13
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
When you stay at Embassy Suites by Hilton St. Louis St. Charles in St. Charles, you'll be connected to the convention center, within a 5-minute drive of Ameristar Casino St. Charles and Hollywood Casino Amphitheatre.
Pool
Breakfast included

Holiday Inn Express Hotel and Suites St. Charles by IHG
3098 Elm Point Industrial Drive St. Charles MO
$127 nightly
The price is $146 total per night
$146 total
Apr 9 - Apr 10
Total with taxes and fees
Free Cancellation
When you stay at Holiday Inn Express Hotel and Suites St. Charles by IHG in St. Charles, you'll be in the historical district, within a 15-minute drive of Hollywood Casino Amphitheatre and Ameristar Casino St. Charles.
Pool
Breakfast included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
St. Charles hotels essential information
Accommodation | 2,378 hotels |
|---|---|
Lowest Price | $103 |
Highest Price | $226 |
Popular hotels | Home2 Suites by Hilton St. Charles St.Louis, Hampton Inn St. Charles St. Peters, Americas Best Value Inn & Suites St. Louis, St. Charles Inn, Ameristar Casino Resort and Spa, Best Western Plus The Charles Hotel, Comfort Suites St Charles - St Louis, Country Inn & Suites by Radisson, St. Charles Historic District, Drury Plaza Hotel St. Louis St. Charles, Embassy Suites by Hilton St. Louis St. Charles, Holiday Inn Express Hotel and Suites St. Charles by IHG, Red Roof Inn St Louis - St Charles, Relax Inn Saint Charles |
Most Recent St. Charles Hotel Reviews

21C Museum Hotel St Louis
4 out of 5
Posted 2 hours ago
CheapTickets Verified Review
"Stayed at 21c and honestly… this place is cool. If you love art, this is your spot. Everywhere you turn there’s something interesting to look at, and it really sets a vibe you don’t get at a typical hotel. The pool was also a highlight, such a unique and relaxing space to unwind.
That said, service was our only real frustration. Our room didn’t get serviced the first day, and we had to call to make sure it would be done the next day. Even then, it didn’t happen until the afternoon. The hotel was at full capacity, and you could tell the staff was exhausted and stretched thin, so it felt more like a staffing issue than a lack of care.
Location-wise, it’s great if you’re planning a trip to the City Museum since it’s within walking distance. Just know there aren’t a ton of restaurant options right around the hotel, so you may need to plan ahead or Uber/drive for more variety.
Overall, we really enjoyed the stay and would come back for the atmosphere alone, just hoping service is a bit smoother next time."
A verified traveler stayed at 21C Museum Hotel St Louis
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