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Featured St. Charles Business Hotels
Home2 Suites by Hilton St. Charles St.Louis
32 Research Park Circle St. Charles MO
Located in St. Charles, Home2 Suites by Hilton St. Charles St.Louis is in the suburbs, a 1-minute drive from Missouri Bluffs Golf Course and 6 minutes from Weldon Spring Site Interpretive Center.
Pool
Hot Tub
Best Western Plus The Charles Hotel
1425 South 5th Street St. Charles MO
$84 nightly
The price is $98 total per night
$98 total
Dec 17 - Dec 18
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
When you stay at Best Western Plus The Charles Hotel in St. Charles, you'll be in the historical district, within a 15-minute walk of Ameristar Casino St. Charles and Historic Main Street.
Pool
Breakfast included
Embassy Suites by Hilton St. Louis St. Charles
2 Convention Center Plz St. Charles MO
$119 nightly
The price is $137 total per night
$137 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Embassy Suites by Hilton St. Louis St. Charles in St. Charles, you'll be connected to the convention center, within a 5-minute drive of Ameristar Casino St. Charles and St Charles Convention Center.
Pool
Breakfast included
Country Inn & Suites by Radisson, St. Charles Historic District
1190 S Main St St. Charles MO
$112 nightly
The price is $128 total per night
$128 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
With a stay at Country Inn & Suites by Radisson, St. Charles Historic District in St. Charles (St. Charles Historic District), you'll be within a 10-minute walk of Ameristar Casino St. Charles and Frontier Park.
Pool
Breakfast included
Ameristar Casino Resort and Spa
1 Ameristar Blvd St. Charles MO
$166 nightly
The price is $194 total per night
$194 total
Dec 14 - Dec 15
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
A stay at Ameristar Casino Resort and Spa places you in the heart of St. Charles, steps from Ameristar Casino St. Charles and a 4-minute drive from Family Arena.
Pool
Hot Tub
Hampton Inn St. Charles St. Peters
3720 W Clay St St. Charles MO
$87 nightly
The price is $100 total per night
$100 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Hampton Inn St. Charles St. Peters in St. Charles, you'll be next to a golf course, within a 10-minute drive of Ameristar Casino St. Charles and Cave Spring Golf Center.
Pool
Hot Tub
Red Roof Inn St Louis - St Charles
2010 Zumbehl Road St. Charles MO
With a stay at Red Roof Inn St Louis - St Charles in St. Charles, you'll be within a 10-minute drive of Ameristar Casino St. Charles and St Charles Convention Center.
Pet friendly
Parking included
Americas Best Value Inn & Suites St. Louis, St. Charles Inn
1310 Bass Pro Drive St. Charles MO
$59 nightly
The price is $69 total per night
$69 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
Located in St. Charles, Americas Best Value Inn & Suites St. Louis, St. Charles Inn is in the historical district, within a 5-minute drive of First Missouri State Capitol Historic Site and Lindenwood University.
Pool
Breakfast included
Comfort Suites St Charles - St Louis
1400 S 5th St St. Charles MO
$80 nightly
The price is $91 total per night
$91 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Comfort Suites St Charles - St Louis, you'll be centrally located in St. Charles, a 8-minute walk from Ameristar Casino St. Charles and 14 minutes by foot from Historic Main Street.
Pool
Breakfast included
Holiday Inn Express Hotel and Suites St. Charles by IHG
3098 Elm Point Industrial Drive St. Charles MO
$119 nightly
The price is $137 total per night
$137 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
With a stay at Holiday Inn Express Hotel and Suites St. Charles by IHG in St. Charles, you'll be in the historical district, within a 15-minute drive of Ameristar Casino St. Charles and Jaycee Park.
Pool
Breakfast included
Drury Plaza Hotel St. Louis St. Charles
380 Mulholland Drive St. Charles MO
$115 nightly
The price is $133 total per night
$133 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
When you stay at Drury Plaza Hotel St. Louis St. Charles in St. Charles, you'll be in the business district, within a 15-minute walk of Ameristar Casino St. Charles and Frontier Park.
Pool
Hot Tub
Sleep Inn & Suites
150 Fountain Lakes Blvd St. Charles MO
$71 nightly
The price is $82 total per night
$82 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free Cancellation
Located in St. Charles, Sleep Inn Saint Charles North is in the historical district, within a 10-minute drive of Fast Lane Classic Cars and Lindenwood University.
Pool
Breakfast included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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St. Charles hotels essential information
Accommodation | 2,300 hotels |
|---|---|
Lowest Price | $69 |
Highest Price | $194 |
Popular hotels | Home2 Suites by Hilton St. Charles St.Louis, Best Western Plus The Charles Hotel, Embassy Suites by Hilton St. Louis St. Charles, Country Inn & Suites by Radisson, St. Charles Historic District, Ameristar Casino Resort and Spa, Hampton Inn St. Charles St. Peters, Red Roof Inn St Louis - St Charles, Americas Best Value Inn & Suites St. Louis, St. Charles Inn, Comfort Suites St Charles - St Louis, Holiday Inn Express Hotel and Suites St. Charles by IHG, Drury Plaza Hotel St. Louis St. Charles, Sleep Inn & Suites |
Most Recent St. Charles Hotel Reviews
Hampton Inn St. Charles St. Peters
5 out of 5
Posted 2 days ago
CheapTickets Verified Review
"Helpful Staff"
A verified traveler stayed at Hampton Inn St. Charles St. Peters
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