Compare Cheap Hotels Near Mississippi River
Secret Bargains - Save an extra 10% or more on select hotels
Get more for your budget and save up to 50% off select Secret Bargain hotels
Get even more value with CheapTickets Price Guarantee!
Change your flight without a fee on select flights
Check dates for Mississippi River hotels
Cheap Mississippi River Hotels

Hollywood Casino & Hotel St. Louis
777 Casino Center Drive Maryland Heights MO
$106 nightly
The price is $124 total per night
$124 total
Apr 1 - Apr 2
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
65.66 mi from Mississippi River
Located in Maryland Heights, Hollywood Casino & Hotel St. Louis is on a river, just a 3-minute walk from Hollywood Casino and a 4-minute drive from Hollywood Casino Amphitheatre.
Free airport shuttle
Parking included

Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
$105 nightly
The price is $122 total per night
$122 total
Mar 22 - Mar 23
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
75.98 mi from Mississippi River
With a stay at Clayton Plaza Hotel & Extended Stay in St. Louis (Clayton), you'll be within a 5-minute drive of Washington University in St. Louis and Forest Park.
Pool
Breakfast included

Drury Plaza Hotel St. Louis at the Arch
2 South 4th Street St. Louis MO
$135 nightly
The price is $158 total per night
$158 total
Mar 15 - Mar 16
Total with taxes and fees
82.09 mi from Mississippi River
A stay at Drury Plaza Hotel St. Louis at the Arch places you in the heart of St. Louis, within a 10-minute walk of Gateway Arch and Busch Stadium.
Pool
Hot Tub

21C Museum Hotel St Louis
1528 Locust street St. Louis MO
$131 nightly
The price is $153 total per night
$153 total
Apr 5 - Apr 6
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
81.27 mi from Mississippi River
A stay at 21C Museum Hotel St Louis places you in the heart of St. Louis, within a 10-minute walk of St. Louis Union Station and City Museum.
Pool
Spa

Hilton St. Louis Airport
10330 Natural Bridge Rd St. Louis MO
$139 nightly
The price is $165 total per night
$165 total
Mar 22 - Mar 23
Total with taxes and fees
70.36 mi from Mississippi River
With a stay at Hilton St. Louis Airport in St. Louis (Woodson Terrace), you'll be within a 15-minute drive of Hollywood Casino Amphitheatre and Ameristar Casino St. Charles.
Free airport shuttle
Pet friendly

Pear Tree Inn St. Louis Airport
10810 Pear Tree Ln St. Ann MO
$90 nightly
The price is $106 total per night
$106 total
Mar 15 - Mar 16
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
69.84 mi from Mississippi River
With a stay at Pear Tree Inn St. Louis Airport, you'll be centrally located in St. Ann, within a 15-minute drive of Hollywood Casino Amphitheatre and Ameristar Casino St. Charles.
Pool
Breakfast included

Renaissance St. Louis Airport Hotel
9801 Natural Bridge Road St. Louis MO
$127 nightly
The price is $148 total per night
$148 total
Mar 29 - Mar 30
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
71.03 mi from Mississippi River
With a stay at Renaissance St. Louis Airport Hotel in St. Louis (Berkeley), you'll be within a 15-minute drive of Hollywood Casino Amphitheatre and Washington University in St. Louis.
Pool
Free airport shuttle

Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
$169 nightly
The price is $199 total per night
$199 total
Mar 23 - Mar 24
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
82.06 mi from Mississippi River
A stay at Hyatt Regency St. Louis at The Arch places you in the heart of St. Louis, within a 10-minute walk of Busch Stadium and Gateway Arch.
Pet friendly
Free WiFi

Ameristar Casino Resort and Spa
1 Ameristar Blvd St. Charles MO
$184 nightly
The price is $215 total per night
$215 total
Apr 5 - Apr 6
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
64.67 mi from Mississippi River
A stay at Ameristar Casino Resort and Spa places you in the heart of St. Charles, steps from Ameristar Casino St. Charles and a 4-minute drive from Family Arena.
Pool
Hot Tub

Best Western St. Louis-Kirkwood Route 66
1200 S Kirkwood Road Kirkwood MO
$94 nightly
The price is $110 total per night
$110 total
Apr 5 - Apr 6
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
78.97 mi from Mississippi River
When you stay at Best Western St. Louis-Kirkwood Route 66 in Kirkwood, you'll be in the suburbs, within a 15-minute drive of Forest Park and Barnes Jewish Hospital.
Pool
Pet friendly

Drury Inn & Suites St. Louis Union Station
201 S 20th St St. Louis MO
$136 nightly
The price is $162 total per night
$162 total
Mar 15 - Mar 16
Total with taxes and fees
81.21 mi from Mississippi River
With a stay at Drury Inn & Suites St. Louis Union Station, you'll be centrally located in St. Louis, just a 5-minute walk from St. Louis Union Station and 11 minutes by foot from Enterprise Center.
Pool
Hot Tub

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
1088 South Highway Drive Fenton MO
$89 nightly
The price is $103 total per night
$103 total
Mar 12 - Mar 13
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
78.62 mi from Mississippi River
A stay at Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham places you in the heart of Fenton, within a 5-minute drive of SSM Health St. Clare Hospital - Fenton and Laumeier Sculpture Park.
Pool
Hot Tub
Don't see what you're looking for?
See all available properties in Mississippi River
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Mississippi River hotels essential information
Accommodation | 15,515 hotels |
|---|---|
Lowest Price | $103 |
Highest Price | $215 |
Popular hotels | Hollywood Casino & Hotel St. Louis, Clayton Plaza Hotel & Extended Stay, Drury Plaza Hotel St. Louis at the Arch, 21C Museum Hotel St Louis , Hilton St. Louis Airport, Pear Tree Inn St. Louis Airport, Renaissance St. Louis Airport Hotel, Hyatt Regency St. Louis at The Arch, Ameristar Casino Resort and Spa, Best Western St. Louis-Kirkwood Route 66, Drury Inn & Suites St. Louis Union Station, Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham |
Most Recent Mississippi River Hotel Reviews

21C Museum Hotel St Louis
5 out of 5
Posted 2 hours ago
CheapTickets Verified Review
"Such a cool hotel I love the museum on the second floor so interesting and all the penguins food is great restaurants great everything just what a great stay very unique but very quiet very cozy love everything about it. Can’t wait to stay at the other ones."
A verified traveler stayed at 21C Museum Hotel St Louis
Hotels Near Mississippi River
Cities near Mississippi River
More to Explore in Mississippi River
Top Picks
Hotels
- Cheap Hotels in Miami
- Cheap Hotels in Los Angeles
- Cheap Hotels in Maui
- Cheap Hotels in Las Vegas
- Cheap Hotels in Palm Springs
- Cheap Hotels in Assateague Island National Seashore
- Cheap Hotels in Atlantic City
- Hotels around Great Smoky Mountains National Park
- Hotels around Carowinds Theme Park
- Cheap Hotels in Myrtle Beach
- Cheap Hotels in Orlando
- Cheap Hotels in New York
- Hotels around Lake Michigan
- Hotels around John Pennekamp Coral Reef State Park
Flights





