Compare Cheap Hotels in Isle of Palms Florida

With a stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area in Jacksonville (Isle of Palms), you'll be a 3-minute drive from Mayo Clinic Florida and 9 minutes from St. Johns Town Center.

With a stay at Margaritaville Jacksonville Beach in Jacksonville Beach (Oceanfront), you'll be a 1-minute drive from Jacksonville Beach Pier and 10 minutes from Mayo Clinic Florida.

Hyatt Regency Jacksonville is centrally located in Jacksonville, a 4-minute walk from Florida Theatre and 11 minutes by foot from Times-Union Center for the Performing Arts.

When you stay at Embassy Suites by Hilton Jacksonville Baymeadows in Jacksonville, you'll be in the business district, within a 15-minute drive of St. Johns Town Center and Mayo Clinic Florida.

Located in Jacksonville (Southside), Wyndham Garden Jacksonville is within a 10-minute drive of St. Johns Town Center and University of North Florida.

With a stay at Hampton Inn Jacksonville Beach/Oceanfront in Jacksonville Beach (Oceanfront), you'll be within a 15-minute drive of Mayo Clinic Florida and Jacksonville Beach Pier.

With a stay at Weekly Inn, you'll be centrally located in Jacksonville, within a 10-minute drive of EverBank Stadium and VyStar Veterans Memorial Arena.

With a stay at The Villas of Amelia Island in Fernandina Beach, you'll be 1.3 mi (2 km) from Fort George Island Cultural State Park and 10 mi (16 km) from Fort Clinch State Park.

With a stay at Omni Amelia Island Resort & Spa in Fernandina Beach, you'll be 2.9 mi (4.7 km) from Fort George Island Cultural State Park and 8.9 mi (14.3 km) from Fort Clinch State Park.

With a stay at Home2 Suites by Hilton Jacksonville Airport in Jacksonville (Northside), you'll be within a 10-minute drive of Jacksonville Zoo and Gardens and UF Health North.

When you stay at Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area in Jacksonville Beach, you'll be in the business district, within a 10-minute drive of Mayo Clinic Florida and Jacksonville Beach Pier.

With a stay at Springhill Suites By Marriott Jacksonville Beach Oceanfront in Jacksonville Beach (Oceanfront), you'll be a 1-minute drive from Jacksonville Beach Pier and 10 minutes from Mayo Clinic Florida.