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Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Property class: 3

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Photo gallery for Residence Inn By Marriott Jacksonville - Mayo Clinic Area

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A modern kitchen with a bar area, seating, and a view of the outdoors.
An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.
A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pet friendly
  • Parking included
  • Free WiFi
  • Air conditioning
The current price is $167
$147 nightly
$167 total
Total with taxes and fees
Sep 18 - Sep 19

Explore the area

View in a map
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL, 32224
  • Place, University of North Florida
    ‪5 min drive‬
  • Place, St. Johns Town Center
    ‪8 min drive‬
  • Place, Mayport Naval Station
    ‪21 min drive‬
  • Airport, Jacksonville, FL (JAX-Jacksonville Intl.)
    ‪34 min drive‬

Room options

View all photos for Studio, 1 King Bed with Sofa bed, Corner

A modern hotel room with a bed, desk, chair, TV, and large windows with curtains.

Studio, 1 King Bed with Sofa bed, Corner

9.8 out of 10
Exceptional
(6 reviews)
  • 533 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 Bedroom, Corner

A modern kitchen with wooden cabinets, a dishwasher, and a countertop with kitchenware. There is a dining area with a table and chairs, and a living room with a sofa and a TV on the wall.

Studio Suite, 1 Bedroom, Corner

10.0 out of 10
Exceptional
(4 reviews)
  • 646 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 King Bed with Sofa bed

A modern kitchen with wooden cabinets, a built-in microwave, and a dishwasher.

Studio Suite, 1 King Bed with Sofa bed

9.6 out of 10
Exceptional
(104 reviews)
  • 407 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 Bedroom

A modern hotel room with a grey sofa, a small round table, a desk with a chair, and a flat-screen TV mounted on the wall.

Studio Suite, 1 Bedroom

9.8 out of 10
Exceptional
(24 reviews)
  • 560 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

A hotel room with a large bed, two bedside tables, and a nightstand with a phone.

Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

9.0 out of 10
Wonderful
(8 reviews)
  • 409 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 King Bed with Sofa bed (Hearing Accessible)

A hotel room with a large bed, two bedside tables, and a nightstand with a phone.

Studio Suite, 1 King Bed with Sofa bed (Hearing Accessible)

9.0 out of 10
Wonderful
(2 reviews)
  • 391 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Roll-In Shower)

A hotel room with a large bed, two bedside tables, and a nightstand with a phone.

Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Roll-In Shower)

10.0 out of 10
Exceptional
(1 review)
  • 391 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 Bedroom (Hearing Accessible)

A modern hotel room with a sofa, desk, and kitchenette.

Studio Suite, 1 Bedroom (Hearing Accessible)

8.0 out of 10
Very good
(1 review)
  • 569 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio, 1 King Bed with Sofa bed, Corner (Hearing Accessible)

A modern hotel room with a bed, desk, chair, TV, and large windows with curtains.

Studio, 1 King Bed with Sofa bed, Corner (Hearing Accessible)

9.0 out of 10
Wonderful
(2 reviews)
  • 538 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 Bedroom, Corner (Mobility/Hearing Access, Roll-In Shwr)

A modern hotel room with a sofa, desk, and kitchenette.

Studio Suite, 1 Bedroom, Corner (Mobility/Hearing Access, Roll-In Shwr)

  • 641 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed
  • Free WiFi

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About the neighborhood

Jacksonville

With a stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area in Jacksonville (Isle of Palms), you'll be a 1-minute drive from Mayo Clinic Florida and 9 minutes from St. Johns Town Center. .This hotel is 10.3 mi (16.5 km) from Mayport Naval Station and 5.2 mi (8.4 km) from University of North Florida.

What's nearby

  • University of North Florida - 5 min drive - 5.6 miles
  • St. Johns Town Center - 8 min drive - 7.9 miles
  • TPC Sawgrass - 15 min drive - 9.1 miles
  • Mayport Naval Station - 21 min drive - 11.6 miles
  • Jacksonville Naval Air Station - 29 min drive - 30.3 miles

Getting around

  • Jacksonville, FL (CRG-Jacksonville Executive at Craig) - 17 min drive

Restaurants

  • ‪Culver’s - ‬4 min drive
  • ‪McDonald's - ‬5 min drive
  • ‪Starbucks - ‬4 min drive
  • ‪Mayo Clinic - Employee Cafeteria - ‬18 min walk
  • ‪1810 Tacos y Tequila - ‬4 min drive

About this property

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area offers 155 air-conditioned accommodations with laptop-compatible safes and coffee/tea makers. Accommodations offer separate sitting areas. 55-inch Smart televisions come with premium cable channels and Netflix. Accommodations at this 3-star hotel have kitchens with refrigerators, stovetops, microwaves, and separate dining areas. Bathrooms include bathtubs or showers, complimentary toiletries, and hair dryers.

This Jacksonville hotel provides complimentary wireless Internet access. Business-friendly amenities include desks and phones. Additionally, rooms include irons/ironing boards and blackout drapes/curtains. Housekeeping is offered daily and change of bedsheets can be requested. Housekeeping is provided on request.

Recreational amenities at the hotel include an outdoor pool and a 24-hour fitness center.
Make yourself at home in one of the 155 air-conditioned rooms featuring kitchens with refrigerators and stovetops. 55-inch Smart televisions with cable programming provide entertainment, while complimentary wireless internet access keeps you connected. Conveniences include phones, as well as laptop-compatible safes and desks.
Be sure to enjoy recreational amenities including an outdoor pool and a 24-hour fitness center. This hotel also features complimentary wireless internet access, concierge services, and wedding services.
Grab a bite from the grocery/convenience store serving guests of Residence Inn By Marriott Jacksonville - Mayo Clinic Area. Relax with your favorite drink at the bar/lounge or the poolside bar. A complimentary buffet breakfast is served on weekdays from 6:30 AM to 9:00 AM and on weekends from 7:00 AM to 9:30 AM.
Featured amenities include a 24-hour business center, express check-out, and complimentary newspapers in the lobby. Planning an event in Jacksonville? This hotel has 2678 square feet (249 square meters) of space consisting of conference space and 2 meeting rooms. Free self parking is available onsite.
A complimentary buffet breakfast is served on weekdays between 6:30 AM and 9:00 AM and on weekends between 7:00 AM and 9:30 AM.

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Free uncovered self parking on site
  • Wheelchair-accessible parking and van parking available

Food and drink

  • Free buffet breakfast available 6:30 AM to 9:00 AM on weekdays and 7:00 AM to 9:30 AM on weekends
  • A bar/lounge
  • A poolside bar
  • Coffee and tea in common areas

Things to do

  • 24-hour gym
  • Outdoor pool
  • TV in common areas

Family friendly

  • Grocery/convenience store
  • In-room kitchen
  • In-room microwave
  • In-room refrigerator
  • Laundry facilities
  • Outdoor pool
  • Separate in-room dining area

Conveniences

  • 24-hour front desk
  • Free newspapers in lobby
  • Grocery/convenience store
  • Laundry facilities
  • Luggage storage
  • Safe at front desk
  • Water dispenser

Guest services

  • Change of bedsheets (on request)
  • Concierge services
  • Dry cleaning/laundry service
  • Free grocery shopping service
  • Housekeeping (daily)
  • Multilingual staff
  • Wedding services

Business services

  • 2 meeting rooms
  • 2,678 square feet of conference space
  • 24-hour business center
  • Computer station
  • Coworking space

Outdoors

  • Barbecue grill
  • Garden
  • Picnic area
  • Pool loungers

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Accessible bathtub
  • Assistive listening devices
  • Assistive listening devices in meeting rooms
  • Bathroom emergency pull cord
  • Braille/raised signage
  • Elevator
  • Grab bar near toilet
  • Hand-held showerhead
  • Handrails in stairways
  • Height-adjustable showerhead
  • Lever door handles
  • Low-height bed
  • Low-height counter and sink
  • Low-height door lock
  • Low-height electrical outlets in bathroom
  • Low-height view port in door
  • Phone accessibility kit
  • Pool hoist on site
  • Raised toilet seat
  • Stair-free path to entrance
  • Vibrating pillow alarm
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible business center
  • Wheelchair-accessible concierge desk
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible van parking
  • Wheelchair-width doorways

More

  • 1 building
  • 7 floors
  • Ballroom
  • Banquet hall
  • Built in 2020
  • Communal living room
  • Comprehensive food waste policy
  • Double-glazed windows
  • Fireplace in lobby
  • No plastic coffee stirrers
  • Non-plastic coffee stirrers available
  • Smoking not allowed
  • Some LED lighting used
  • Traditional architecture
  • Vegan dining options
  • Vegetarian breakfast available
  • Vegetarian dining options

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathtub or shower
  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Food and drink

  • Coffee/tea maker
  • Cookware, dishware, and utensils
  • Dishwasher
  • Kitchen
  • Microwave
  • Refrigerator
  • Separate dining area
  • Stovetop
  • Toaster

More

  • Air conditioning
  • Connecting rooms available
  • Desk
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Separate sitting area
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 6:00 AM
Contactless check-in available
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 150 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs and cats only
2 total (up to 40 lbs per pet)
Restrictions apply; for more information contact the property at the number on the booking confirmation

Children and extra beds

Children are welcome
Cribs (infant beds) are not available

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Deposit: USD 125 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Pet fee: USD 150 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Cashless transactions are available
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, and window guards

We should mention

Only registered guests are allowed in the guestrooms
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

Residence INN BY Marriott Jacksonville
Residence Inn by Marriott Jacksonville East
Residence Inn Jacksonville Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic Area Hotel

Residence Inn By Marriott Jacksonville - Mayo Clinic Area Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 476 out of 588 reviews
Rating 8 - Good. 76 out of 588 reviews
Rating 6 - Okay. 14 out of 588 reviews
Rating 4 - Poor. 14 out of 588 reviews
Rating 2 - Terrible. 8 out of 588 reviews

9.6/10

Cleanliness

9.6/10

Staff & service

9.2/10

Amenities

9.6/10

Property conditions & facilities

Reviews

Verified review

10/10 Excellent

Chad

Great place to stay!
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Lauren

Liked: Cleanliness
Great room, breakfast was fantastic
Stayed 1 night in May 2026
Verified review

10/10 Excellent

clipper

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We love this hotel.. everything you need and more, great staff!!!
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Jon

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Perfect location for Mayo Clinic appointments.
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Md Sadequr Rahman

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room extremely clean, good staff, buffet breakfast and nice kitchen in studio room.
Stayed 2 nights in May 2026
Verified review

10/10 Excellent

Melody

Liked: Cleanliness, staff & service, property conditions & facilities
We enjoyed our stay. Breakfast was good and stocked well. Love the proximity to Mayo Clinic.
Stayed 2 nights in May 2026
Verified review

10/10 Excellent

Lori

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean room, helpful staff, and good complimentary breakfast. Complimentary shuttle to the Mayo Clinic too!!
Stayed 2 nights in May 2026
Verified review

8/10 Good

Nancy

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean room, staff were very helpful, room was comfortable
Stayed 2 nights in Apr 2026
Verified review

10/10 Excellent

Kristey

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The suite room we had was nice with a full kitchen, dining and living area that was separate from the sleeping area. I will definitely recommend this room to anyone needing to stay near the Mayo Clinic.
Stayed 2 nights in May 2026
Verified review

10/10 Excellent

Sabrena

Great stay! Clean room, friendly staff.
Stayed 1 night in Jan 2026
Verified review

10/10 Excellent

Thomas

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Exceptional staff at this location. Provided excellent service during stay. Utilized shuttle services which were extremely helpful. Would not hesitate to stay here again.
Stayed 2 nights in May 2026
Verified review

10/10 Excellent

Gregory

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
My family and I were there for a wedding this weekend. One of the most enjoyable hotel stay experiences ever. Great rooms. Exceptionally friendly staff. I look forward to coming back.
Stayed 3 nights in May 2026
Verified review

10/10 Excellent

STEVEN

Liked: Cleanliness, staff & service, amenities
Conveniently located, clean rooms, excellent breakfast
Stayed 2 nights in Jan 2026
Verified review

10/10 Excellent

Tamara

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great room, very clean and comfortable. Staff was wonderful and friendly. Perfect location for our stay for appointments at Mayo. The shuttle was very convenient for dropping us right at the door for my Mayo appointment.
Stayed 2 nights in May 2026
Verified review

10/10 Excellent

Melanie

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Good area, convenient but not too busy. Staff very friendly and informative. Nice, clean room.
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Vashti

Liked: Cleanliness, staff & service, property conditions & facilities
Good breakfast
Stayed 4 nights in Apr 2026
Verified review

10/10 Excellent

Darlene

Liked: Cleanliness, amenities, property conditions & facilities
Clean room, amazing staff great location
Stayed 1 night in Dec 2025
Verified review

10/10 Excellent

Jill

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Location was very perfect for an appointment at The Mayo Clinic. Staff could not have been nicer.
Stayed 1 night in Apr 2026
Verified review

8/10 Good

Elisa

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very clean Staff friendly and helpful Bed is pretty hard I prefer softer Otherwise everything else's great
Stayed 2 nights in May 2026
Verified review

8/10 Good

M

Liked: Cleanliness, staff & service, property conditions & facilities
Good location to multiple attractions in the city. Love the free and easily accessible parking.
Stayed 2 nights in Mar 2026
Verified review

10/10 Excellent

Jennifer

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The motel was clean inside and out food was excellent staff was nice and friendly shuttle to and from the mayo clinic was a blessing not to have to worry about driving in traffic they also would shop for groceries for you all you had to do was give them a list I recommend staying there loved it
Stayed 2 nights in Apr 2026
Verified review

10/10 Excellent

Anthony

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean and well equipped room. Very good buffet breakfast
Stayed 3 nights in Apr 2026
Verified review

10/10 Excellent

JOHN

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Breakfast was ok nothing special but the staff were all helpful and upbeat. Would highly recommend this property especially if you’re going to Mayo Clinic.
Stayed 1 night in Mar 2026
Verified review

10/10 Excellent

clipper

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Large well laid out rooms!
Stayed 2 nights in Apr 2026
Verified review

10/10 Excellent

Robin

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very clean hotel and nice room. Great breakfast included. Very close to Mayo but not on campus. There used to be a shuttle! I would recommend.
Stayed 2 nights in May 2026