Important: This destination may have COVID-19 travel restrictions in place, including specific restrictions for lodging. Check any national, local, and health advisories for this destination before you book.

Cheap flights from Portland (PDX) to Knoxville (TYS)

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Lowest round trip fares by airline from Portland and Knoxville

Cheapest prices ($134 One Way, $337 Round Trip) found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Mon, Aug 9
PDX
Portland
TYS
Knoxville
$134
Frontier Airlines
Fri, Sep 24
PDX
Portland
TYS
Knoxville
$198
Frontier Airlines
Fri, Aug 6
PDX
Portland
TYS
Knoxville
$203
Frontier Airlines
Fri, Jul 23
PDX
Portland
TYS
Knoxville
$241
Frontier Airlines
Tue, Aug 31
PDX
Portland
TYS
Knoxville
$245
American Airlines
Fri, Jul 30 - Wed, Aug 4
PDX
Portland
TYS
Knoxville
$337
Frontier Airlines
Fri, Jul 23 - Fri, Aug 6
PDX
Portland
TYS
Knoxville
$374
Frontier Airlines
Sat, Sep 18 - Sat, Sep 25
PDX
Portland
TYS
Knoxville
$383
United
Fri, Jul 30 - Mon, Aug 2
PDX
Portland
TYS
Knoxville
$395
Frontier Airlines
Sat, Sep 18 - Sat, Sep 25
PDX
Portland
TYS
Knoxville
$398
United

Great Deals On Cheap Hotels in Knoxville

Motel 6 Knoxville, TN

Motel 6 Knoxville, TN

2 out of 5
258 Harry Lane Blvd, Knoxville, TN
The price is $60 per night from Jun 15 to Jun 15
Situated in Knoxville, this motel is 2.5 mi (4 km) from Dead Horse Lake Golf Course and within 6 mi (10 km) of West Town Mall and Turkey Creek Shopping Center. ...
2.6/5 (5 reviews)
I wish I could get a voucher or my money back!
"The only bright spot about the entire trip was Rebecca the desk clerk. The rest was horrible. Between the loud slamming of doors, people screaming, arguing at all hours of night up into the light of day, I was miserable."

Reviewed on Jul 29, 2018

Motel 6 Knoxville, TN
Red Roof Inn Knoxville Central - Papermill Road

Red Roof Inn Knoxville Central - Papermill Road

2 out of 5
1315 Kirby Rd, Knoxville, TN
The price is $68 per night from Jun 20 to Jun 20
Situated near the airport, this hotel is 1.9 mi (3.1 km) from Bearden Antique Mall and 2.8 mi (4.4 km) from West Town Mall. Tennessee River is 2.4 mi (3.9 km) ...
2.5/5 (2 reviews)
Not a good experience
"Did not vacuum during the 5 days Bathroom was not mopped"

Reviewed on Apr 30, 2017

Red Roof Inn Knoxville Central - Papermill Road
Red Roof Inn PLUS+ & Suites Knoxville West – Cedar Bluff

Red Roof Inn PLUS+ & Suites Knoxville West – Cedar Bluff

2.5 out of 5
208 Market Pl Blvd, Knoxville, TN
The price is $83 per night from Jun 15 to Jun 15
Situated in the suburbs, this motel is within 9 mi (15 km) of West Town Mall, Pellissippi State Community College, and Willow Creek Golf Club. Knoxville Museum ...
Red Roof Inn PLUS+ & Suites Knoxville West – Cedar Bluff
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Fly From Portland to Knoxville

Origin Portland
Destination Knoxville
Number of Daily Flights
Earliest Flight Departure Date
Latest Flight Departure Date
Popular Airlines

Cheap flights from Portland to Knoxville

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Save Even More Time and Money With a Knoxville Travel Package

Once your flights are booked, why start all over again searching for a cheap hotel? Book your flight and hotel together, and save yourself more than time and energy. You'll also be able to take advantage of discounts and coupons on your Knoxville vacation that you can't get when you book flights and hotel separately.

Relax in Knoxville With Confidence and Convenience

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*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.