Compare Cheap Hotels in Puxico
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Cheap Puxico Hotels
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
$76 nightly
The price is $80 total per night
$80 total
Dec 13 - Dec 14
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
19.43 mi from city center
Located in Poplar Bluff, Motel 6 Poplar Bluff, MO is a 3-minute drive from Poplar Bluff Regional Medical Center and 5 minutes from Mark Twain National Forest.
Fairfield Inn & Suites by Marriott Poplar Bluff
3109 Oak Grove Poplar Bluff MO
$104 nightly
The price is $118 total per night
$118 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
19.19 mi from city center
Located in Poplar Bluff, Fairfield Inn & Suites by Marriott Poplar Bluff is a 1-minute drive from Poplar Bluff Regional Medical Center and 8 minutes from Mark Twain National Forest.
Holiday Inn Poplar Bluff by IHG
2781 N Westwood Blvd Poplar Bluff MO
$101 nightly
The price is $114 total per night
$114 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
18.83 mi from city center
A stay at Holiday Inn Poplar Bluff by IHG places you in the heart of Poplar Bluff, within a 5-minute drive of Poplar Bluff Regional Medical Center and North Main Street Historic District.
Drury Inn & Suites Poplar Bluff
2220 N Westwood Blvd Poplar Bluff MO
$94 nightly
The price is $106 total per night
$106 total
Dec 17 - Dec 18
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
18.82 mi from city center
A stay at Drury Inn & Suites Poplar Bluff places you in the heart of Poplar Bluff, within a 5-minute drive of Poplar Bluff Regional Medical Center and North Main Street Historic District.
Hampton Inn Poplar Bluff
2420 Crestwood Dr Poplar Bluff MO
$91 nightly
The price is $102 total per night
$102 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
18.83 mi from city center
Located in Poplar Bluff, Hampton Inn Poplar Bluff is in a rural location, within a 5-minute drive of Poplar Bluff Regional Medical Center and North Main Street Historic District.
Hampton Inn By Hilton Dexter
2179 Gill Plaza Drive Dexter MO
$98 nightly
The price is $110 total per night
$110 total
Dec 19 - Dec 20
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
13.6 mi from city center
Located in Dexter, Hampton Inn By Hilton Dexter is within a 5-minute drive of Southeast Health Center of Stoddard County and The Heritage House.
Dexter Inn
1807 W Business US Highway 60 Dexter MO
$65 nightly
The price is $73 total per night
$73 total
Dec 13 - Dec 14
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
13.75 mi from city center
Located in Dexter, Dexter Inn is in a rural location, within a 5-minute drive of Southeast Health Center of Stoddard County and The Heritage House.
Super 8 by Wyndham Poplar Bluff Missouri
2831 N Westwood Blvd Poplar Bluff MO
$56 nightly
The price is $63 total per night
$63 total
Dec 18 - Dec 19
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
18.77 mi from city center
Located in Poplar Bluff, Super 8 by Wyndham Poplar Bluff Missouri is within a 5-minute drive of Poplar Bluff Regional Medical Center and North Main Street Historic District.
Travelodge by Wyndham Dexter
1608 E Business US 60 Dexter MO
$74 nightly
The price is $83 total per night
$83 total
Dec 14 - Dec 15
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
13.87 mi from city center
Located in Dexter, Travelodge by Wyndham Dexter is within a 5-minute drive of Southeast Health Center of Stoddard County and The Heritage House.
Lake Wappapello
8005 Missouri 172 Williamsville MO
16.6 mi from city center
Located in Williamsville, Lake Wappapello is a 1-minute drive from Mark Twain National Forest and 10 minutes from Poplar Bluff Regional Medical Center.
EC Reed's Mercantile and Hotel
301 1st St Marble Hill MO
$105 nightly
The price is $114 total per night
$114 total
Dec 15 - Dec 16
Total with taxes and fees
26.03 mi from city center
With a stay at EC Reed's Mercantile and Hotel in Marble Hill, you'll be 12.7 mi (20.4 km) from Bollinger Mill State Historic Site and 29.9 mi (48.1 km) from Southeast Missouri State University.
Econo Lodge Dexter
913 Outer Rd Dexter MO
$59 nightly
The price is $67 total per night
$67 total
Jan 10 - Jan 11, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
14.24 mi from city center
With a stay at Econo Lodge Dexter in Dexter, you'll be a 5-minute walk from Southeast Health Center of Stoddard County and within a 5-minute drive of The Heritage House.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Puxico hotels essential information
Accommodation | 56 hotels |
|---|---|
Lowest Price | $63 |
Highest Price | $118 |
Popular hotels | Motel 6 Poplar Bluff, MO, Fairfield Inn & Suites by Marriott Poplar Bluff, Holiday Inn Poplar Bluff by IHG, Drury Inn & Suites Poplar Bluff, Hampton Inn Poplar Bluff, Hampton Inn By Hilton Dexter, Dexter Inn, Super 8 by Wyndham Poplar Bluff Missouri, Travelodge by Wyndham Dexter, Lake Wappapello, EC Reed's Mercantile and Hotel, Econo Lodge Dexter |
Most Recent Puxico Hotel Reviews
Holiday Inn Poplar Bluff by IHG
5 out of 5
Posted 3 days ago
CheapTickets Verified Review
"Clean and very well kept."
A verified traveler stayed at Holiday Inn Poplar Bluff by IHG
- Lake Wappapello
- OYO Hickory House Inn
- Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided
- Dexter Homestead. Very Cozy & NEW Remodel !
- Camp Stonebass-Lake House-Hottub
- Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff
- Cozy hobby farm cabin under the stars!
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