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Cheap Southeast Missouri Hotels

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
$53 nightly
The price is $60 total per night
$60 total
Dec 26 - Dec 27
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
37.99 mi from city center
Located in Farmington, Baymont Inn and Suites by Wyndham Farmington, MO is in the historical district, within a 15-minute drive of Crown Pointe Golf Club and St. Joe State Park.
Pool
Breakfast included
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
$90 nightly
The price is $102 total per night
$102 total
Dec 23 - Dec 24
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
46.88 mi from city center
With a stay at Drury Plaza Hotel Cape Girardeau Conference Center in Cape Girardeau, you'll be connected to the convention center, within a 10-minute drive of Mississippi River and Saint Francis Medical Center.
Pool
Hot Tub
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
$76 nightly
The price is $80 total per night
$80 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
29.15 mi from city center
Located in Poplar Bluff, Motel 6 Poplar Bluff, MO is a 3-minute drive from Poplar Bluff Regional Medical Center and 5 minutes from Mark Twain National Forest.
Pet friendly
Parking included
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
$96 nightly
The price is $109 total per night
$109 total
Dec 22 - Dec 23
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
50.35 mi from city center
When you stay at The Riverview in Cape Girardeau, you'll be in the entertainment district, within a 15-minute walk of Mississippi River and Isle Casino Cape Girardeau.
Parking included
Free WiFi
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
$84 nightly
The price is $91 total per night
$91 total
Jan 7 - Jan 8, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
45.7 mi from city center
With a stay at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau in Jackson, you'll be in the business district, within a 15-minute drive of Mississippi River and Cape Girardeau Conservation Nature Center.
Pool
Breakfast included
The Farmstead Hotel

The Farmstead Hotel

2.5 out of 5
778 E 3rd St Caruthersville MO
$95 nightly
The price is $108 total per night
$108 total
Dec 20 - Dec 21
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
83.3 mi from city center
Located in Caruthersville, The Farmstead Hotel is in the entertainment district, a 4-minute walk from Century Casino Caruthersville and 5 minutes by foot from Mississippi River.
Parking included
Free WiFi
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
$98 nightly
The price is $110 total per night
$110 total
Dec 28 - Dec 29
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
53.02 mi from city center
When you stay at Hampton Inn Sikeston in Sikeston, you'll be near the airport, within a 5-minute drive of Central Park and Sikeston Depot Museum.
Pool
Breakfast included
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
$93 nightly
The price is $106 total per night
$106 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
68.37 mi from city center
Located in Festus, La Quinta Inn & Suites by Wyndham Festus - St. Louis South is in a rural location, within a 5-minute drive of Jorkerst Memorial Park and Festus Public Library.
Breakfast included
Pet friendly
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3 out of 5
2781 N Westwood Blvd Poplar Bluff MO
$110 nightly
The price is $124 total per night
$124 total
Dec 23 - Dec 24
Total with taxes and fees
Free Cancellation
30.18 mi from city center
A stay at Holiday Inn Poplar Bluff by IHG places you in the heart of Poplar Bluff, within a 5-minute drive of Poplar Bluff Regional Medical Center and North Main Street Historic District.
Pool
Pet friendly
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$90 nightly
The price is $103 total per night
$103 total
Dec 22 - Dec 23
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
54.11 mi from city center
A stay at Drury Inn & Suites Sikeston, MO places you in the heart of Sikeston, a 1-minute drive from City of Miner Convention Center and 5 minutes from Sikeston Depot Museum.
Pool
Breakfast included
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St. Cape Girardeau MO
$116 nightly
The price is $131 total per night
$131 total
Dec 28 - Dec 29
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
50.01 mi from city center
Located in Cape Girardeau, Courtyard by Marriott Cape Girardeau Downtown is within a 15-minute walk of Shawnee National Forest and eDen Spa & Salon.
Parking included
Free WiFi
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3 out of 5
2220 N Westwood Blvd Poplar Bluff MO
$94 nightly
The price is $106 total per night
$106 total
Dec 22 - Dec 23
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
30.64 mi from city center
A stay at Drury Inn & Suites Poplar Bluff places you in the heart of Poplar Bluff, within a 5-minute drive of Poplar Bluff Regional Medical Center and North Main Street Historic District.
Pool
Hot Tub
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Southeast Missouri hotels essential information

Accommodation
620 hotels
Lowest Price
$60
Highest Price
$131
Popular hotels
Baymont Inn and Suites by Wyndham Farmington, MO, Drury Plaza Hotel Cape Girardeau Conference Center, Motel 6 Poplar Bluff, MO, The Riverview, La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, The Farmstead Hotel, Hampton Inn Sikeston, La Quinta Inn & Suites by Wyndham Festus - St. Louis South, Holiday Inn Poplar Bluff by IHG, Drury Inn & Suites Sikeston, MO, Courtyard by Marriott Cape Girardeau Downtown, Drury Inn & Suites Poplar Bluff

Most Recent Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

5 out of 5
Posted 15 hours ago
CheapTickets Verified Review
"Everything was well done"
A verified traveler stayed at Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO