Compare Cheap Hotels in Southeast Missouri

When you stay at Drury Plaza Hotel Cape Girardeau Conference Center in Cape Girardeau, you'll be connected to the convention center, within a 10-minute drive of Shawnee National Forest and Mississippi River.

A stay at Drury Inn & Suites Sikeston, MO places you in the heart of Sikeston, a 1-minute drive from City of Miner Convention Center and 5 minutes from Sikeston Depot Museum.

Located in Farmington, Baymont Inn and Suites by Wyndham Farmington, MO is in the historical district, within a 10-minute drive of Crown Pointe Golf Club and St. Joe State Park.

Located in Cape Girardeau, Pear Tree Inn Cape Girardeau West is in a rural location, a 3-minute drive from Saint Francis Medical Center and 5 minutes from Saint Francis Healthcare System.

Located in Poplar Bluff, Hampton Inn Poplar Bluff is in a rural location, within a 5-minute drive of Poplar Bluff Regional Medical Center and Poplar Bluff History Museum.

Located in Sikeston, Days Inn and Suites by Wyndham Sikeston is a 3-minute drive from City of Miner Convention Center and 7 minutes from Sikeston Depot Museum.

When you stay at The Riverview in Cape Girardeau, you'll be in the entertainment district, within a 15-minute walk of Mississippi River and Shawnee National Forest.

With a stay at Comfort Inn Festus - St Louis South in Festus, you'll be within a 10-minute drive of Mississippi River and Jorkerst Memorial Park.

When you stay at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau in Jackson, you'll be in the business district, within a 15-minute drive of Shawnee National Forest and Mississippi River.

With a stay at Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy in French Village, you'll be in a regional park, and 10.6 mi (17.1 km) from Weingarten Vineyard and 15.1 mi (24.3 km) from Hawn State Park.

Located in Ste Genevieve, this vacation home is in a rural location, a 5-minute drive from Crown Valley Winery and 5 minutes from Hawn State Park.

When you stay at Hampton Inn Sikeston in Sikeston, you'll be near the airport, within a 5-minute drive of Central Park and Sikeston Depot Museum.