Compare Cheap Hotels in Southeast Missouri

Secret Bargains - Save an extra 10% or more on select hotels

Start date: Check-in selected.
To Date
End date: Check-out

Get more for your budget and save up to 50% off select Secret Bargain hotels

Get even more value with CheapTickets Price Guarantee!

Change your flight without a fee on select flights

Cheap Southeast Missouri Hotels

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
$53 nightly
The price is $60 total per night
$60 total
Dec 28 - Dec 29
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
37.99 mi from city center
Located in Farmington, Baymont Inn and Suites by Wyndham Farmington, MO is in the historical district, within a 15-minute drive of Crown Pointe Golf Club and St. Joe State Park.
Pool
Breakfast included
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
$90 nightly
The price is $102 total per night
$102 total
Dec 22 - Dec 23
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
46.88 mi from city center
With a stay at Drury Plaza Hotel Cape Girardeau Conference Center in Cape Girardeau, you'll be connected to the convention center, within a 10-minute drive of Mississippi River and Saint Francis Medical Center.
Pool
Hot Tub
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
$76 nightly
The price is $80 total per night
$80 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
29.15 mi from city center
Located in Poplar Bluff, Motel 6 Poplar Bluff, MO is a 3-minute drive from Poplar Bluff Regional Medical Center and 5 minutes from Mark Twain National Forest.
Pet friendly
Parking included
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
$132 nightly
The price is $149 total per night
$149 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
50.35 mi from city center
When you stay at The Riverview in Cape Girardeau, you'll be in the entertainment district, within a 15-minute walk of Mississippi River and Isle Casino Cape Girardeau.
Parking included
Free WiFi
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
$84 nightly
The price is $91 total per night
$91 total
Jan 7 - Jan 8, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
45.7 mi from city center
With a stay at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau in Jackson, you'll be in the business district, within a 15-minute drive of Mississippi River and Cape Girardeau Conservation Nature Center.
The Farmstead Hotel

The Farmstead Hotel

2.5 out of 5
778 E 3rd St Caruthersville MO
$95 nightly
The price is $108 total per night
$108 total
Dec 19 - Dec 20
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
83.3 mi from city center
Located in Caruthersville, The Farmstead Hotel is in the entertainment district, a 4-minute walk from Century Casino Caruthersville and 5 minutes by foot from Mississippi River.
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
$98 nightly
The price is $111 total per night
$111 total
Dec 28 - Dec 29
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
53.02 mi from city center
When you stay at Hampton Inn Sikeston in Sikeston, you'll be near the airport, within a 5-minute drive of Central Park and Sikeston Depot Museum.
Pool
Breakfast included
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
$93 nightly
The price is $106 total per night
$106 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
68.37 mi from city center
Located in Festus, La Quinta Inn & Suites by Wyndham Festus - St. Louis South is in a rural location, within a 5-minute drive of Jorkerst Memorial Park and Festus Public Library.
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3 out of 5
2781 N Westwood Blvd Poplar Bluff MO
$101 nightly
The price is $114 total per night
$114 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
30.18 mi from city center
A stay at Holiday Inn Poplar Bluff by IHG places you in the heart of Poplar Bluff, within a 5-minute drive of Poplar Bluff Regional Medical Center and North Main Street Historic District.
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$90 nightly
The price is $103 total per night
$103 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
54.11 mi from city center
A stay at Drury Inn & Suites Sikeston, MO places you in the heart of Sikeston, a 1-minute drive from City of Miner Convention Center and 5 minutes from Sikeston Depot Museum.
Pool
Breakfast included
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St. Cape Girardeau MO
$116 nightly
The price is $131 total per night
$131 total
Dec 27 - Dec 28
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
50.01 mi from city center
Located in Cape Girardeau, Courtyard by Marriott Cape Girardeau Downtown is within a 15-minute walk of Shawnee National Forest and eDen Spa & Salon.
Parking included
Free WiFi
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 out of 5
3109 Oak Grove Poplar Bluff MO
$104 nightly
The price is $117 total per night
$117 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
30.02 mi from city center
Located in Poplar Bluff, Fairfield Inn & Suites by Marriott Poplar Bluff is a 1-minute drive from Poplar Bluff Regional Medical Center and 8 minutes from Mark Twain National Forest.
Pool
Breakfast included
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Often, one of the most difficult things about booking a hotel is finding the best time to go. The cost of staying in hotels in could vary significantly, depending on the time of the year chosen. If you would like to figure out the most suitable time to take a trip then using CheapTickets could be the best option for you. We will be able to provide information on hotels in to ensure that you get the best deal possible. So if you are looking for a booking website that will streamline the process and offer good prices, then log in and get booking.

Southeast Missouri hotels essential information

Accommodation
620 hotels
Lowest Price
$60
Highest Price
$149
Popular hotels
Baymont Inn and Suites by Wyndham Farmington, MO, Drury Plaza Hotel Cape Girardeau Conference Center, Motel 6 Poplar Bluff, MO, The Riverview, La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, The Farmstead Hotel, Hampton Inn Sikeston, La Quinta Inn & Suites by Wyndham Festus - St. Louis South, Holiday Inn Poplar Bluff by IHG, Drury Inn & Suites Sikeston, MO, Courtyard by Marriott Cape Girardeau Downtown, Fairfield Inn & Suites by Marriott Poplar Bluff

Most Recent Southeast Missouri Hotel Reviews

The Farmstead Hotel

The Farmstead Hotel

5 out of 5
Posted 3 days ago
CheapTickets Verified Review
"Nice place "
A verified traveler stayed at The Farmstead Hotel
The Farmstead Hotel