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Cheap Southeast Missouri Hotels

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
$54 nightly
The price is $62 total per night
$62 total
Dec 11 - Dec 12
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
37.99 mi from city center
Located in Farmington, Baymont Inn and Suites by Wyndham Farmington, MO is in the historical district, within a 15-minute drive of Crown Pointe Golf Club and St. Joe State Park.
Pool
Breakfast included
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
$90 nightly
The price is $102 total per night
$102 total
Dec 9 - Dec 10
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
46.88 mi from city center
When you stay at Drury Plaza Hotel Cape Girardeau Conference Center in Cape Girardeau, you'll be connected to the convention center, within a 5-minute drive of Saint Francis Medical Center and Saint Francis Healthcare System.
Pool
Hot Tub
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
$107 nightly
The price is $121 total per night
$121 total
Dec 7 - Dec 8
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
50.35 mi from city center
With a stay at The Riverview in Cape Girardeau, you'll be in the entertainment district, just a 2-minute walk from Isle Casino Cape Girardeau and 12 minutes by foot from Mississippi River.
Parking included
Free WiFi
Baymont by Wyndham Festus

Baymont by Wyndham Festus

3 out of 5
1200 W. Gannon Drive Festus MO
$77 nightly
The price is $87 total per night
$87 total
Dec 7 - Dec 8
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
68.15 mi from city center
With a stay at Baymont by Wyndham Festus in Festus, you'll be 8.7 mi (14.1 km) from Villa Antonio Winery and 25.6 mi (41.2 km) from Grant's Farm.
Pool
Breakfast included
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
$76 nightly
The price is $80 total per night
$80 total
Dec 7 - Dec 8
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
29.15 mi from city center
Located in Poplar Bluff, Motel 6 Poplar Bluff, MO is a 3-minute drive from Poplar Bluff Regional Medical Center and 5 minutes from Mark Twain National Forest.
Pet friendly
Parking included
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
$78 nightly
The price is $85 total per night
$85 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
45.7 mi from city center
When you stay at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau in Jackson, you'll be in the business district, within a 5-minute drive of Cape Girardeau Conservation Nature Center and Saint Francis Healthcare System.
Pool
Breakfast included
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
$95 nightly
The price is $108 total per night
$108 total
Dec 14 - Dec 15
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
53.02 mi from city center
When you stay at Hampton Inn Sikeston in Sikeston, you'll be near the airport, within a 5-minute drive of Central Park and Sikeston Depot Museum.
Pool
Breakfast included
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3 out of 5
2781 N Westwood Blvd Poplar Bluff MO
$99 nightly
The price is $112 total per night
$112 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free Cancellation
30.18 mi from city center
A stay at Holiday Inn Poplar Bluff by IHG places you in the heart of Poplar Bluff, within a 5-minute drive of Poplar Bluff Regional Medical Center and North Main Street Historic District.
Pool
Pet friendly
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
$70 nightly
The price is $79 total per night
$79 total
Dec 9 - Dec 10
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
46.79 mi from city center
Located in Cape Girardeau, Pear Tree Inn Cape Girardeau West is in a rural location, within a 5-minute drive of Saint Francis Medical Center and Saint Francis Healthcare System.
Breakfast included
Pet friendly
The Farmstead Hotel

The Farmstead Hotel

2.5 out of 5
778 E 3rd St Caruthersville MO
$95 nightly
The price is $108 total per night
$108 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
83.3 mi from city center
Located in Caruthersville, The Farmstead Hotel is in the entertainment district, a 4-minute walk from Century Casino Caruthersville and 5 minutes by foot from Mississippi River.
Parking included
Free WiFi
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St. Cape Girardeau MO
$116 nightly
The price is $131 total per night
$131 total
Dec 25 - Dec 26
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
50.01 mi from city center
Located in Cape Girardeau, Courtyard by Marriott Cape Girardeau Downtown is within a 15-minute walk of Shawnee National Forest and eDen Spa & Salon.
Parking included
Free WiFi
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 out of 5
3109 Oak Grove Poplar Bluff MO
$104 nightly
The price is $118 total per night
$118 total
Dec 7 - Dec 8
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
30.02 mi from city center
Located in Poplar Bluff, Fairfield Inn & Suites by Marriott Poplar Bluff is a 1-minute drive from Poplar Bluff Regional Medical Center and 8 minutes from Mark Twain National Forest.
Pool
Breakfast included
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Southeast Missouri hotels essential information

Accommodation
617 hotels
Lowest Price
$62
Highest Price
$131
Popular hotels
Baymont Inn and Suites by Wyndham Farmington, MO, Drury Plaza Hotel Cape Girardeau Conference Center, The Riverview, Baymont by Wyndham Festus, Motel 6 Poplar Bluff, MO, La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, Hampton Inn Sikeston, Holiday Inn Poplar Bluff by IHG, Pear Tree Inn Cape Girardeau West, The Farmstead Hotel, Courtyard by Marriott Cape Girardeau Downtown, Fairfield Inn & Suites by Marriott Poplar Bluff

Most Recent Southeast Missouri Hotel Reviews

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

5 out of 5
Posted 2 days ago
CheapTickets Verified Review
"Was very good stay"
A verified traveler stayed at Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO