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Featured Panama City Boutique Hotels

De Ville Hotel

De Ville Hotel

4.5 out of 5
50 street and Beatriz M. De Cabal Panama City
A stay at De Ville Hotel places you in the heart of Panama City, within a 15-minute walk of Via Espana and Avenida Balboa.
Gatto Blanco Party Hotel

Gatto Blanco Party Hotel

3.5 out of 5
Avenida B con Calle 8 Panama City Panama
A stay at Gatto Blanco Party Hotel places you in the heart of Panama City, within a 15-minute walk of Avenida Balboa and Cinta Costera.
Free WiFi
Restaurant
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Avenida Aquilino de La Guardia Panama City Panama
$200 nightly
The price is $220 total per night
$220 total
Jan 3 - Jan 4, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Bristol Panama, a Registry Collection Hotel, you'll be centrally located in Panama City, steps from Calle 50 and within a 10-minute walk of Soho City Center.
Pool
Spa
Hotel Casa Panamá

Hotel Casa Panamá

4 out of 5
Avenida Eloy Alfaro y Calle 11 Panama City
$73 nightly
The price is $80 total per night
$80 total
Jan 6 - Jan 7, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
Located in Panama City (Casco Viejo), Hotel Casa Panamá is within a 10-minute walk of Avenida Balboa and Cinta Costera.
The Saba Hotel

The Saba Hotel

3.5 out of 5
Panama Internacional zone,Argentina Ave Panama City Panama
With a stay at The Saba Hotel, you'll be centrally located in Panama City, within a 5-minute drive of Albrook Shopping Mall and Via Espana.
Exe Oriental Panama

Exe Oriental Panama

4 out of 5
Avenida 2da Sur, Obarrio, Bella Vista Panama City Panama
$72 nightly
The price is $79 total per night
$79 total
Dec 13 - Dec 14
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Exe Oriental Panama in Panama City (Bella Vista), you'll be a 3-minute walk from Via Espana and 14 minutes by foot from Avenida Balboa.
Free WiFi
Restaurant
American Trade Hotel

American Trade Hotel

4.5 out of 5
Plaza Herrera Casco Viejo Panama City Panama
$262 nightly
The price is $289 total per night
$289 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
American Trade Hotel is in the heart of Panama City, within a 5-minute walk of Museum of History Panama and Independence Square.
Toscana Inn

Toscana Inn

3.5 out of 5
Via España, Calle D El Cangrejo Panama City Panama (province)
Free Cancellation
Reserve now, pay when you stay
With a stay at Toscana Inn, you'll be centrally located in Panama City, within a 5-minute drive of Via Espana and Avenida Balboa.
Las Clementinas

Las Clementinas

3.5 out of 5
Casco Antiguo, Calle 11 Y Ave B Panama City Panama
$129 nightly
The price is $142 total per night
$142 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
Located in Panama City (Casco Viejo), Las Clementinas is within a 15-minute walk of Avenida Balboa and Cinta Costera.
Riande Urban Hotel

Riande Urban Hotel

3.5 out of 5
El Cangrejo; Calle Eusebio A, Morales Panama City Panama
$72 nightly
The price is $79 total per night
$79 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Riande Urban Hotel in Panama City (Bella Vista), you'll be within a 5-minute drive of Via Espana and Avenida Balboa.
Tantalo Hotel

Tantalo Hotel

3.5 out of 5
Calle 8 Este con Avenida B, Casco Viejo Panama City Panama
Free Cancellation
Reserve now, pay when you stay
With a stay at Tantalo Hotel in Panama City (Casco Viejo), you'll be within a 15-minute walk of Avenida Balboa and Cinta Costera.
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
$113 nightly
The price is $125 total per night
$125 total
Jan 8 - Jan 9, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Decapolis Hotel Panama City, you'll be centrally located in Panama City, steps from Avenida Balboa and Multicentro Panama.
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Panama City hotels essential information

Accommodation
1,633 hotels
Lowest Price
$79
Highest Price
$289
Popular hotels
De Ville Hotel, Gatto Blanco Party Hotel, Bristol Panama, a Registry Collection Hotel, Hotel Casa Panamá, The Saba Hotel, Exe Oriental Panama, American Trade Hotel, Toscana Inn, Las Clementinas, Riande Urban Hotel, Tantalo Hotel, Decapolis Hotel Panama City

Most Recent Panama City Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Posted 14 hours ago
CheapTickets Verified Review
"The Staff was Amazing. Pamela at the hotels store mad my fiancé and I feel like family. The rooms are spacious and clean. "
A verified traveler stayed at Hotel Riu Plaza Panama
Hotel Riu Plaza Panama

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