Cheap flights from Des Moines (DSM) to Knoxville (TYS)

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Lowest round trip fares by airline from Des Moines and Knoxville

Cheapest prices ( One Way, $368 Round Trip) found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Great Deals On Cheap Hotels in Knoxville

Motel 6 Knoxville, TN

Motel 6 Knoxville, TN

2 out of 5
258 Harry Lane Blvd, Knoxville, TN, 37923
The price is $60 per night from Dec 1 to Dec 2
$60
per night
Dec 1 - Dec 2
Stay at this business-friendly motel in Knoxville. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the comfy rooms and the overall ...
2.9/5 (1,000 reviews)
"liked area, couldn't park in front of room. not enough spaces. wood floor was dirty, no bathroom door, couldn't open closet door."

Reviewed on Nov 14, 2022

Motel 6 Knoxville, TN
Red Roof Inn Knoxville Central - Papermill Road

Red Roof Inn Knoxville Central - Papermill Road

2 out of 5
1315 Kirby Rd, Knoxville, TN, 37909
The price is $69 per night from Dec 1 to Dec 2
$69
per night
Dec 1 - Dec 2
Stay at this business-friendly hotel in Knoxville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the pool and the helpful staff in our ...
3.5/5 Good! (1,000 reviews)
"It was clean and comfortable. We were traveling home from Thanksgiving and was a perfect stop."

Reviewed on Nov 28, 2022

Red Roof Inn Knoxville Central - Papermill Road
Red Roof Inn PLUS+ & Suites Knoxville West – Cedar Bluff

Red Roof Inn PLUS+ & Suites Knoxville West – Cedar Bluff

2.5 out of 5
208 Market Pl Blvd, Knoxville, TN, 37922
The price is $79 per night from Dec 1 to Dec 2
$79
per night
Dec 1 - Dec 2
Stay at this business-friendly motel in Knoxville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms ...
3.8/5 Good! (1,002 reviews)
Pretty good!
"Generally a good stay. Room fairly clean but dated."

Reviewed on Nov 21, 2022

Red Roof Inn PLUS+ & Suites Knoxville West – Cedar Bluff
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Fly From Des Moines to Knoxville

Origin Des Moines
Destination Knoxville
Number of Daily Flights
Earliest Flight Departure Date
Latest Flight Departure Date
Popular Airlines

Cheap flights from Des Moines to Knoxville

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Save Even More Time and Money With a Knoxville Travel Package

Once your flights are booked, why start all over again searching for a cheap hotel? Book your flight and hotel together, and save yourself more than time and energy. You'll also be able to take advantage of discounts and coupons on your Knoxville vacation that you can't get when you book flights and hotel separately.

Relax in Knoxville With Confidence and Convenience

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*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.