Compare Cheap Hotels in Vandalia

Secret Bargains - Save an extra 10% or more on select hotels

Cheap Vandalia Hotels

Comfort Inn & Suites - Hannibal

4000 Market St Hannibal MO

$83 nightly

$96 total

Dec 28 - Dec 29

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

26.41 mi from city center

With a stay at Comfort Inn & Suites - Hannibal, you'll be centrally located in Hannibal, within a 15-minute drive of Mississippi River and Sodalis Nature Preserve.

Pool

Hot Tub

Knights Inn New Florence

Booneslick Road, 403, 403 New Florence MO

$68 nightly

$77 total

Dec 17 - Dec 18

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

28.08 mi from city center

With a stay at Knights Inn New Florence in New Florence, you'll be 8.4 mi (13.5 km) from Endless Summer Winery and 16.3 mi (26.2 km) from Hermannhof Vineyards.

Breakfast included

Pet friendly

Best Western Teal Lake Inn

3602 S Clark St Mexico MO

$94 nightly

$105 total

Dec 21 - Dec 22

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

24.06 mi from city center

With a stay at Best Western Teal Lake Inn in Mexico, you'll be steps from Green Estates and a 1-minute drive from Lakeview Park.

Pool

Breakfast included

Days Inn by Wyndham Hannibal

4070 Market St Hannibal MO

$63 nightly

$72 total

Dec 29 - Dec 30

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

26.41 mi from city center

With a stay at Days Inn by Wyndham Hannibal in Hannibal, you'll be in the business district, within a 15-minute drive of Mississippi River and Sodalis Nature Preserve.

Breakfast included

Pet friendly

Baymont by Wyndham Hannibal

4141 Market St Hannibal MO

$65 nightly

$75 total

Dec 17 - Dec 18

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

26.35 mi from city center

With a stay at Baymont by Wyndham Hannibal, you'll be centrally located in Hannibal, within a 15-minute drive of Mississippi River and Sodalis Nature Preserve.

Pool

Breakfast included

Days Inn by Wyndham Mexico

2902 S. Clark Mexico MO

$77 nightly

$86 total

Jan 11 - Jan 12, 2026

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

24.24 mi from city center

With a stay at Days Inn by Wyndham Mexico in Mexico, you'll be within a 5-minute drive of Green Estates and Lakeview Park.

Breakfast included

Parking included

Super 8 by Wyndham Bowling Green

1216 E Champ Clark Dr Bowling Green MO

16.46 mi from city center

With a stay at Super 8 by Wyndham Bowling Green in Bowling Green, you'll be 14.2 mi (22.9 km) from Mississippi River and 17.3 mi (27.8 km) from Ramsey Creek Church.

Breakfast included

Parking included

Cannon Dam Cabins

42526 Cabin Rd Perry MO

$103 nightly

$109 total

Dec 17 - Dec 18

Total with taxes and fees

16.61 mi from city center

With a stay at Cannon Dam Cabins in Perry, you'll be 0.9 mi (1.5 km) from Mark Twain Lake and 12.6 mi (20.3 km) from Mark Twain State Park.

Pool

Pet friendly

Howard Johnson BY Wyndham Hannibal

4141B MARKET ST Hannibal MO

$58 nightly

$67 total

Dec 17 - Dec 18

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

26.33 mi from city center

With a stay at Howard Johnson BY Wyndham Hannibal in Hannibal, you'll be within a 15-minute drive of Mississippi River and Sodalis Nature Preserve.

Pool

Pet friendly

The Junction Inn

28804 MO-19 Perry MO

$84 nightly

$89 total

Dec 21 - Dec 22

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

11.58 mi from city center

When you stay at The Junction Inn in Perry, you'll be near the beach and within a 5-minute drive of Bill Trower Memorial Park.

Parking included

Free WiFi

Kennedys Red Barn Inn

22748 Joanna Dr Perry MO

$91 nightly

$97 total

Dec 17 - Dec 18

Total with taxes and fees

16.53 mi from city center

Located in Perry, Kennedys Red Barn Inn is on a lake, within a 15-minute drive of Mark Twain Lake and Perry Park.

Hot Tub

Breakfast included

3 Bedroom 2 Bath Cabin nestled in the woods minutes from Mark Twain Lake.

Stoutsville MO

25.49 mi from city center

Located in Stoutsville, this vacation home is on a lake, within a 10-minute drive of Stoutsville Recreation Area and Mark Twain Lake.

Kitchen

Washer

Don't see what you're looking for?

See all available properties in Vandalia

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Often, one of the most difficult things about booking a hotel is finding the best time to go. The cost of staying in hotels in could vary significantly, depending on the time of the year chosen. If you would like to figure out the most suitable time to take a trip then using CheapTickets could be the best option for you. We will be able to provide information on hotels in to ensure that you get the best deal possible. So if you are looking for a booking website that will streamline the process and offer good prices, then log in and get booking.

Vandalia hotels essential information

Accommodation	58 hotels
Lowest Price	$67
Highest Price	$109
Popular hotels	Comfort Inn & Suites - Hannibal, Knights Inn New Florence, Best Western Teal Lake Inn, Days Inn by Wyndham Hannibal, Baymont by Wyndham Hannibal, Days Inn by Wyndham Mexico, Super 8 by Wyndham Bowling Green, Cannon Dam Cabins, Howard Johnson BY Wyndham Hannibal, The Junction Inn, Kennedys Red Barn Inn, 3 Bedroom 2 Bath Cabin nestled in the woods minutes from Mark Twain Lake.

Most Recent Vandalia Hotel Reviews

Howard Johnson BY Wyndham Hannibal

5 out of 5

Posted 9 days ago

CheapTickets Verified Review

"The gentleman at the front desk was extremely nice and did everything to make my stay wonderful. The breakfast was awesome. The pool was sooo nice. The exercise room was great. I cannot say anything bad about this hotel. This was the first time I stayed here and I will be coming back every three months.!"

A verified traveler stayed at Howard Johnson BY Wyndham Hannibal