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Featured Cape Girardeau Hotels with WiFi
Hampton Inn Cape Girardeau I 55 East
207 S Mt Auburn Rd Cape Girardeau MO
$99 nightly
The price is $112 total per night
$112 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
Located in Cape Girardeau, Hampton Inn Cape Girardeau I 55 East is within a 5-minute drive of Saint Francis Medical Center and Saint Francis Healthcare System.
Pool
Breakfast included
Candlewood Suites Cape Girardeau by IHG
485 S Mount Auburn Rd Cape Girardeau MO
$70 nightly
The price is $84 total per night
$84 total
Dec 14 - Dec 15
Total with taxes and fees
Free Cancellation
Located in Cape Girardeau, Candlewood Suites Cape Girardeau by IHG is a 3-minute drive from Saint Francis Medical Center and 5 minutes from Fort D Historic Site.
Pool
Pet friendly
Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
$90 nightly
The price is $102 total per night
$102 total
Dec 9 - Dec 10
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
A stay at Drury Inn & Suites Cape Girardeau places you in the heart of Cape Girardeau, within a 5-minute drive of Saint Francis Medical Center and Saint Francis Healthcare System.
Pool
Hot Tub
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
$90 nightly
The price is $102 total per night
$102 total
Dec 9 - Dec 10
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
When you stay at Drury Plaza Hotel Cape Girardeau Conference Center in Cape Girardeau, you'll be connected to the convention center, within a 5-minute drive of Saint Francis Medical Center and Saint Francis Healthcare System.
Pool
Hot Tub
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
$95 nightly
The price is $107 total per night
$107 total
Dec 28 - Dec 29
Total with taxes and fees
Free Cancellation
Located in Cape Girardeau, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is in a rural location, within a 5-minute drive of Saint Francis Medical Center and Saint Francis Healthcare System.
Pool
Breakfast included
Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St Cape Girardeau MO
$70 nightly
The price is $79 total per night
$79 total
Dec 9 - Dec 10
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
A stay at Pear Tree Inn Cape Girardeau Near the Medical Center places you in the heart of Cape Girardeau, within a 5-minute drive of Saint Francis Medical Center and Saint Francis Healthcare System.
Pet friendly
Free WiFi
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
$70 nightly
The price is $79 total per night
$79 total
Dec 9 - Dec 10
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
Located in Cape Girardeau, Pear Tree Inn Cape Girardeau West is in a rural location, within a 5-minute drive of Saint Francis Medical Center and Saint Francis Healthcare System.
Breakfast included
Pet friendly
Quality Inn
2011 North Kingshighway Cape Girardeau MO
$58 nightly
The price is $65 total per night
$65 total
Dec 11 - Dec 12
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Quality Inn in Cape Girardeau, you'll be within a 5-minute drive of Saint Francis Healthcare System and Cape Splash Family Aquatic Center.
Pool
Breakfast included
Town House Inn Cape Giradreau
505 North Kingshighway Street Cape Girardeau MO
$57 nightly
The price is $64 total per night
$64 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Town House Inn Cape Giradreau in Cape Girardeau, you'll be within a 5-minute drive of Southeast Missouri Hospital and Southeast Missouri State University.
Pet friendly
Parking included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Cape Girardeau hotels essential information
Accommodation | 172 hotels |
|---|---|
Lowest Price | $64 |
Highest Price | $112 |
Popular hotels | Hampton Inn Cape Girardeau I 55 East, Candlewood Suites Cape Girardeau by IHG, Drury Inn & Suites Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Center, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG, Pear Tree Inn Cape Girardeau Near the Medical Center, Pear Tree Inn Cape Girardeau West, Quality Inn, Town House Inn Cape Giradreau, Historical 'Kage House' Short Term Rental located in "Old Town Cape" |
Most Recent Cape Girardeau Hotel Reviews
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
5 out of 5
Posted 4 days ago
CheapTickets Verified Review
"Great customer service!! The people next to our room were very loud with children yelling amd running around all night. "
A verified traveler stayed at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
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