Compare Hotels with Suites in Cape Girardeau

Name: Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Price range: $107 total

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Featured Cape Girardeau Hotels with Suites

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

$90 nightly

$102 total

Dec 18 - Dec 19

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

With a stay at Drury Inn & Suites Cape Girardeau, you'll be centrally located in Cape Girardeau, within a 10-minute drive of Mississippi River and Saint Francis Medical Center.

Pool

Hot Tub

Candlewood Suites Cape Girardeau by IHG

485 S Mount Auburn Rd Cape Girardeau MO

$70 nightly

$84 total

Jan 11 - Jan 12, 2026

Total with taxes and fees

Free Cancellation

With a stay at Candlewood Suites Cape Girardeau by IHG in Cape Girardeau, you'll be within a 10-minute drive of Mississippi River and Saint Francis Medical Center.

Pool

Pet friendly

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

$95 nightly

$107 total

Dec 22 - Dec 23

Total with taxes and fees

Free Cancellation

With a stay at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG in Cape Girardeau, you'll be near the airport, within a 10-minute drive of Mississippi River and Saint Francis Medical Center.

Pool

Breakfast included

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Cape Girardeau hotels essential information

Accommodation	173 hotels
Lowest Price	$84
Highest Price	$107
Popular hotels	Drury Inn & Suites Cape Girardeau, Candlewood Suites Cape Girardeau by IHG, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG