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Featured Panama Luxury Hotels

JW Marriott Panama

Calle Punta Colon, Punta Pacifica Panama City Panama

$279 nightly

$307 total

Dec 14 - Dec 15

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

Centrally located in Panama City, JW Marriott Panama is within a 15-minute walk of Multiplaza Pacific Mall and Avenida Balboa.

Pool

Spa

Bristol Panama, a Registry Collection Hotel

Avenida Aquilino de La Guardia Panama City Panama

$184 nightly

$202 total

Dec 12 - Dec 13

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

With a stay at Bristol Panama, a Registry Collection Hotel, you'll be centrally located in Panama City, steps from Calle 50 and within a 10-minute walk of Soho City Center.

Waldorf Astoria Panama

47th St. & Uruguay Street Panama City Panama

$180 nightly

$198 total

Dec 16 - Dec 17

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

A stay at Waldorf Astoria Panama places you in the heart of Panama City, within a 5-minute drive of Multicentro Panama and Multiplaza Pacific Mall.

American Trade Hotel

Plaza Herrera Casco Viejo Panama City Panama

$262 nightly

$289 total

Jan 5 - Jan 6, 2026

Total with taxes and fees

American Trade Hotel is in the heart of Panama City, within a 5-minute walk of Museum of History Panama and Independence Square.

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

56 y 57 East Street, Obarrio Panama City Panama

$159 nightly

$175 total

Dec 13 - Dec 14

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

A stay at Sortis Hotel, Spa & Casino, Autograph Collection by Marriott places you in the heart of Panama City, within a 15-minute walk of Via Espana and Avenida Balboa.

Hilton Panama

Balboa Ave. and Aquilino De La Guardia Panama City

$186 nightly

$205 total

Jan 2 - Jan 3, 2026

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

A stay at Hilton Panama places you in the heart of Panama City, within a 5-minute drive of Multicentro Panama and Multiplaza Pacific Mall.

Megapolis Hotel Panamá

Ave. Balboa al lado de Multicentro, 63 Panama City Panamá Province

With a stay at Megapolis Hotel Panamá, you'll be centrally located in Panama City, steps from Multicentro Panama and Avenida Balboa.

The Buenaventura Golf & Beach Resort Panama, Autograph Collection

340 Calle 3ra Buenaventura El Chiru Cocle

$278 nightly

$306 total

Jan 6 - Jan 7, 2026

Total with taxes and fees

With a stay at The Buenaventura Golf & Beach Resort Panama, Autograph Collection in El Chiru, you'll be 1.8 mi (2.9 km) from Buenaventura Marina and 8 mi (12.9 km) from Santa Clara Beach.

Las Americas Golden Tower Panama

Av. Balboa con Calle 53 Panama City Panama

$175 nightly

$192 total

Dec 14 - Dec 15

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

With a stay at Las Americas Golden Tower Panama, you'll be centrally located in Panama City, a 4-minute walk from Multicentro Panama and a 2-minute drive from Fiesta Casino.

Marriott Panama Hotel

Roosevelt Ave., Allbrook Mall Panama City Panama

$142 nightly

$156 total

Dec 12 - Dec 13

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

A stay at Marriott Panama Hotel places you in the heart of Panama City, steps from Albrook Shopping Mall and a 3-minute drive from Anthropological Museum Reina Torres de Arauz.

Doubletree By Hilton Panama City El Carmen

Via Espana Ave. Federico Boyd Bel Panama City Panama Province

With a stay at Doubletree By Hilton Panama City El Carmen, you'll be centrally located in Panama City, a 8-minute walk from Avenida Balboa and 11 minutes by foot from Cinta Costera.

Metro Hotel Panama

Via Veneto, Calle D El Cangrejo Panama City Panama

Free Cancellation

Reserve now, pay when you stay

A stay at Metro Hotel Panama places you in the heart of Panama City, just a 5-minute walk from Via Espana and within a 5-minute drive of Avenida Balboa.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Panama Luxury Hotels essential information

Luxury Hotels in Panama	67
Highest price	$307
Cheapest price	$156
Total number of hotels in Panama	3,584
Popular hotels	JW Marriott Panama, Bristol Panama, a Registry Collection Hotel, Waldorf Astoria Panama, American Trade Hotel, Sortis Hotel, Spa & Casino, Autograph Collection by Marriott, Hilton Panama, Megapolis Hotel Panamá, The Buenaventura Golf & Beach Resort Panama, Autograph Collection, Las Americas Golden Tower Panama, Marriott Panama Hotel, Doubletree By Hilton Panama City El Carmen, Metro Hotel Panama