See all 2969 hotels in Upstate South Carolina
- Days Inn by Wyndham Easley/Greenville/Clemson Area
- Home2 Suites by Hilton Anderson Downtown
- Holiday Inn Anderson by IHG
- Quality Inn Seneca Clemson Area US-123
- Best Western Plus Spartanburg
- Holiday Inn Express & Suites Greenville-Spartanburg (Duncan) by IHG
- Homewood Suites by Hilton Greenville
- Hampton Inn & Suites Spartanburg-I-26-Westgate Mall
- Hampton Inn Greenville/Travelers Rest
- Fairfield Inn & Suites Seneca Clemson Univ Area
- Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
- WoodSpring Suites Greenville Haywood Mall
- WoodSpring Suites Greenville Simpsonville
- Best Western Plus Greenville South
- Home2 Suites by Hilton Duncan
- Inn on the Square, an Ascend Collection Hotel
- Home2 Suites by Hilton Greenville Airport
- Baymont by Wyndham Anderson Clemson
- Holiday Inn Express & Suites Greenwood Mall by IHG
- Days Inn by Wyndham Clemson
- Red Roof Inn & Suites Greenwood, SC
- Days Inn by Wyndham Greenville South/Mauldin
- Hilton Garden Inn Spartanburg
- Hampton Inn Anderson/ Alliance Business Park
- Fairfield By Marriott Inn & Suites Piedmont Greenville
- Holiday Inn Express & Suites Clemson by IHG
- Baymont by Wyndham Greenwood
- Hampton Inn Easley
- Greenville Pelham Inn by IHG
- Hampton Inn Clemson-University Area
- WoodSpring Suites Greenville Central I-85
- Hampton Inn Anderson
- Comfort Suites Anderson-Clemson
- Red Roof Inn Greenville
- Quality Inn Simpsonville - Greenville
- Extended Stay America Premier Suites Greenville Woodruff Rd
- Courtyard Marriott Clemson
- Hampton Inn & Suites Clinton - I-26
- Quality Inn Union US Hwy 176
- Extended Stay America Select Suites Greenville Haywood Mall
- Comfort Inn & Suites Greenwood near University
- Candlewood Suites Greenville by IHG
- Super 8 by Wyndham Greer/Spartanburg Area
- Fairfield Inn & Suites by Marriott Greenwood
- Holiday Inn Spartanburg Northwest by IHG
- Days Inn by Wyndham Simpsonville
- Days Inn by Wyndham Spartanburg
- Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG
- Residence Inn by Marriott Anderson Clemson
- USA Economy Lodge
- Quality Inn Gaffney I-85
- Quality Inn Duncan - Spartanburg West
- WoodSpring Suites Spartanburg - Duncan
- Fairfield Inn & Suites by Marriott Anderson Clemson
- Quality Inn Spartanburg Northwest
- Quality Inn Greer - Greenville
- stayAPT Suites Greenville Greer BMW
- Holiday Inn Express Anderson by IHG
- Red Roof Inn Spartanburg - I-85
- Hampton Inn Greenwood
- Rodeway Inn
- Red Roof Inn Spartanburg – I-26
- Hometowne Studios Greenville
- Staybridge Suites Greenville I-85 Woodruff Road by IHG
- Hotel Domestique
- Red Roof Inn & Suites Duncan
- Super 8 by Wyndham Piedmont Greenville Area
- Quality Inn Greenwood Hwy 25
- Red Roof Inn Gaffney
- Comfort Suites Clinton near Presbyterian College
- Liberty Hall Bed and Breakfast
- Americas Best Value Inn Anderson, SC
- Residence Inn by Marriott Spartanburg Westgate
- Econo Lodge Gaffney
- Motel 6 Simpsonville, SC - Greenville
- Budget Inn Express
- Rodeway Inn & Suites Walhalla
- BEAUTIFUL Newly Built Retreat w/Private Marina Boat Slip at Upper Lake Keowee!!!
- Sleep Inn Gaffney at I-85
- Pettigru Place Bed & Breakfast