See all 2969 hotels in Upstate South Carolina
- Fairfield Inn & Suites by Marriott Greenville Spartanburg/Duncan
- AUG/SEPT SALE FIREPIT TREE-FORT RETREAT 6 miles to Reedy Falls, 1.5 to Conastee
- Charming 4-bedroom farmhouse w/ WiFi, AC in lovely Eastatoee Valley, Sunset, SC.
- ✨ Steps from the Swamp Rabbit Trail, Tandem Coffee, Topsoil and more.
- Studio Near Falls Park on Reedy – Functional Space for Long Stays - 2 Units
- Econo Lodge
- Sunrise Inn
- Whole Hearts Bed and Breakfast
- InTown Suites Extended Stay Anderson SC - Clemson University
- MULTIPLE Cottage stay on Saluda River Farms for up to 20+
- Tanglewood Inn
- SUN AND SAND MOTEL
- Extended Stay America Select Suites - Greenville - Airport
- Charming 1-bedroom farmhouse in marvelous Seneca with WiFi, AC
- Private Room #3
- Boutique hotel in historic downtown Seneca. Room #4, King bed.
- Rodeway Inn
- Lodge on the Waterfall!
- Charming 3-bedroom farmhouse in wonderful Seneca with Sunset views over the farm
- Suburban Studios Spartanburg - I-26
- Fairfield by Marriott Inn & Suites Spartanburg Downtown
- Modern Remodeled Farmhouse - Great Location
- Pet-Friendly Room Near Falls Park on Reedy and Downtown Greenville Fun
- SC Farmstead Cottage with modern amenities and farm views
- Private Suite in Downtown Simpsonville
- Boutique hotel in historic downtown Seneca. Room #5, two King beds.
- Peaceful Lakefront Getaway Close to Clemson
- 2 Rooms Ideal for Long Stays Near Frankie’s Fun Park – Just 6 Km Away
- Super 8 by Wyndham Gaffney
- The Night Inn
- Farm Stay Loft Apt | Sleeps 5
- Tucker Farm Cottage on Century Farm
- Whiffletree Farmhouse just 2 mins off I-26 & 8 mins from d-town Spartanburg!
- Downtown Greenville Lux Carriage House—Walk to Main St, SR Trail, The Well Arena
- Delightful Duck Farm cottage, 5 min walk to State Park! Gated, a hidden gem!
- Holy Cow Farms a large modern Farm House.11 miles from Tryon TIEC. Pool & HotTub
- Light and airy contemporary guest house with private deck and parking.
- Boutique hotel in historic downtown Seneca. Room #6, King Bed.
- Pet-Friendly Room Near Falls Park on Reedy and Downtown Greenville Fun
- Spacious Retreat: Near GVL & AVL, Luxe Touches
- Modern Suite with Kitchen Near Greenville Airport – 10 Min Drive for Travelers
- Room Near Greenville Zoo – Perfect Family Stay & City Exploration
- Chauga River - The Guest House - Private - Secluded
- Quality Inn Clemson Near University
- Clemson Lodge
- Keowee Cove Dock & Lake Views!
- Pet-Friendly Budget Room Close to Michelin HQ & Paris Mountain Park
- 7 BR Bunk House in Cozy Campobello Sleeps 28
- Boutique hotel in historic downtown Seneca. Room#1, Q/K combo.
- 4 Pet-Friendly Rooms w/ Kitchen Near Roper Mountain Science Center & Attraction
- 3-bedroom Farmhouse at the Base of the Blue
Ridge Mountains
- Doubletree By Hilton Greenville Airport
- Poolside Mountain Views and Outdoor Living
- Bright and beautiful Cottage near Spartanburg , Tryon Intl Eq Center, Asheville.
- Moments Happen Here: 10 acres
- Lake Hartwell Escape
- Boutique hotel in historic downtown Seneca. Room #2 Owners Suite. Q/K combo.
- 4 Spacious Rooms Near Michelin HQ – Perfect for Business Trips & Extended Stays
- Rodeway Inn and Suites Walhalla SC
- Royal Inn
- Pet-Friendly Lakefront Suite w/ Dock, Canoe, Firepit & More
- 3 Suites with Kitchen Near Greenville Airport – Ideal for Work or Long Stays
- 2 Affordable Rooms Close to Greenville’s Family-Friendly Attractions
- Zoka - Modern Mountain Retreat
- 3 Pet-Friendly Suites Ideal for Long Visits Near Greenville’s Key Attractions
- Oak Knob Equestrian Home
- 2 Furnished Rooms for Budget Travelers Near Greenville’s Popular Attractions
- Cozy 2-bedroom Rooftop apartment in charming Old Mill Village, Campobello
- Charming farmhouse with AC in Boiling Springs
- Budget Inn
- Holiday Inn
- Tru by Hilton
- Lake Keowee Cabin: Peaceful and Bright
- Cozy, Country Cottage
- Holiday Inn Woodruff Road
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