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Independent in Seneca

Quality Inn Seneca Clemson Area US-123

226 Hi Tech Rd Seneca SC

$79 nightly

$87 total

Dec 21 - Dec 22

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

0.16 mi from city center

With a stay at Quality Inn Seneca Clemson Area US-123, you'll be centrally located in Seneca, within a 15-minute drive of Clemson University and The Gauntlet.

Lakeside Lodge Clemson

13500 Clemson Blvd Seneca SC

$123 nightly

$135 total

Dec 14 - Dec 15

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

5.27 mi from city center

With a stay at Lakeside Lodge Clemson in Seneca, you'll be within a 5-minute drive of Clemson University and Lake Hartwell.

Tru by Hilton Seneca Clemson

13050 Clemson Blvd Seneca SC

$95 nightly

$105 total

Dec 21 - Dec 22

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

5.12 mi from city center

When you stay at Tru by Hilton Seneca Clemson in Seneca, you'll be in a shopping district, within a 5-minute drive of Clemson University and Littlejohn Coliseum.

Hampton Inn & Suites Seneca-Clemson Area

1011 East North 1st Street Seneca SC

$102 nightly

$112 total

Jan 11 - Jan 12, 2026

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

1.15 mi from city center

With a stay at Hampton Inn & Suites Seneca-Clemson Area in Seneca, you'll be in the business district, within a 10-minute drive of Clemson University and Wyndham Plaza.

Days Inn by Wyndham Seneca / Clemson Area

11015 N Radio Station Rd Seneca SC

$71 nightly

$79 total

Dec 21 - Dec 22

Total with taxes and fees

1.92 mi from city center

With a stay at Days Inn by Wyndham Seneca / Clemson Area in Seneca, you'll be in the business district, within a 15-minute drive of Clemson University and Applewood Shopping Center.

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

299 Outpost Rd Seneca SC

$129 nightly

$142 total

Jan 5 - Jan 6, 2026

Total with taxes and fees

4.92 mi from city center

Located in Seneca, Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy is in a regional park, a 1-minute drive from Lake Hartwell and 7 minutes from Friendship Recreaction Area.

Best Western Seneca-Clemson

511 Bypass Highway 123 Seneca SC

$89 nightly

$98 total

Dec 21 - Dec 22

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

0.81 mi from city center

With a stay at Best Western Seneca-Clemson in Seneca, you'll be within a 10-minute drive of Clemson University and Lake Keowee.

Fairfield Inn & Suites Seneca Clemson Univ Area

800 BYPASS 123 Seneca SC

$115 nightly

$127 total

Dec 21 - Dec 22

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

1.08 mi from city center

With a stay at Fairfield Inn & Suites Seneca Clemson Univ Area in Seneca, you'll be on a lake, within a 10-minute drive of Clemson University and Lake Keowee.

Fabulous Tiny House with AC in charming Seneca

Seneca SC

3.68 mi from city center

Located in Seneca, this cabin is within a 15-minute drive of Lake Keowee and Golden Corner Plaza.

6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.

Seneca SC

6 mi from city center

With a stay at this vacation home in Seneca, you'll be on the waterfront, within a 15-minute drive of Clemson University and Lake Hartwell.

Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock

Seneca SC

5.36 mi from city center

Located in Seneca, this vacation home is on a lake, within a 15-minute drive of Lake Keowee and Keowee Key Golf Course.

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

Seneca SC

10.15 mi from city center

Located in Seneca, this vacation home is on the waterfront, a 1-minute drive from Lake Keowee and 8 minutes from High Falls County Park.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Seneca hotels essential information

Accommodation	1,652 hotels
Lowest Price	$79
Highest Price	$142
Popular hotels	Quality Inn Seneca Clemson Area US-123, Lakeside Lodge Clemson, Tru by Hilton Seneca Clemson, Hampton Inn & Suites Seneca-Clemson Area, Days Inn by Wyndham Seneca / Clemson Area, Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy, Best Western Seneca-Clemson, Fairfield Inn & Suites Seneca Clemson Univ Area , Fabulous Tiny House with AC in charming Seneca, 6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water., Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock, Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub