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Independent in Seneca

Quality Inn Seneca Clemson Area US-123
226 Hi Tech Rd Seneca SC
$79 nightly
The price is $87 total per night
$87 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.16 mi from city center
With a stay at Quality Inn Seneca Clemson Area US-123, you'll be centrally located in Seneca, within a 15-minute drive of Clemson University and The Gauntlet.

Lakeside Lodge Clemson
13500 Clemson Blvd Seneca SC
$123 nightly
The price is $135 total per night
$135 total
Dec 14 - Dec 15
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
5.27 mi from city center
With a stay at Lakeside Lodge Clemson in Seneca, you'll be within a 5-minute drive of Clemson University and Lake Hartwell.

Tru by Hilton Seneca Clemson
13050 Clemson Blvd Seneca SC
$95 nightly
The price is $105 total per night
$105 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
5.12 mi from city center
When you stay at Tru by Hilton Seneca Clemson in Seneca, you'll be in a shopping district, within a 5-minute drive of Clemson University and Littlejohn Coliseum.

Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street Seneca SC
$102 nightly
The price is $112 total per night
$112 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
1.15 mi from city center
With a stay at Hampton Inn & Suites Seneca-Clemson Area in Seneca, you'll be in the business district, within a 10-minute drive of Clemson University and Wyndham Plaza.

Days Inn by Wyndham Seneca / Clemson Area
11015 N Radio Station Rd Seneca SC
$71 nightly
The price is $79 total per night
$79 total
Dec 21 - Dec 22
Total with taxes and fees
1.92 mi from city center
With a stay at Days Inn by Wyndham Seneca / Clemson Area in Seneca, you'll be in the business district, within a 15-minute drive of Clemson University and Applewood Shopping Center.

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
299 Outpost Rd Seneca SC
$129 nightly
The price is $142 total per night
$142 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
4.92 mi from city center
Located in Seneca, Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy is in a regional park, a 1-minute drive from Lake Hartwell and 7 minutes from Friendship Recreaction Area.

Best Western Seneca-Clemson
511 Bypass Highway 123 Seneca SC
$89 nightly
The price is $98 total per night
$98 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.81 mi from city center
With a stay at Best Western Seneca-Clemson in Seneca, you'll be within a 10-minute drive of Clemson University and Lake Keowee.

Fairfield Inn & Suites Seneca Clemson Univ Area
800 BYPASS 123 Seneca SC
$115 nightly
The price is $127 total per night
$127 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
1.08 mi from city center
With a stay at Fairfield Inn & Suites Seneca Clemson Univ Area in Seneca, you'll be on a lake, within a 10-minute drive of Clemson University and Lake Keowee.

Fabulous Tiny House with AC in charming Seneca
Seneca SC
3.68 mi from city center
Located in Seneca, this cabin is within a 15-minute drive of Lake Keowee and Golden Corner Plaza.

6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.
Seneca SC
6 mi from city center
With a stay at this vacation home in Seneca, you'll be on the waterfront, within a 15-minute drive of Clemson University and Lake Hartwell.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Seneca hotels essential information
Accommodation | 1,652 hotels |
|---|---|
Lowest Price | $79 |
Highest Price | $142 |
Popular hotels | Quality Inn Seneca Clemson Area US-123, Lakeside Lodge Clemson, Tru by Hilton Seneca Clemson, Hampton Inn & Suites Seneca-Clemson Area, Days Inn by Wyndham Seneca / Clemson Area, Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy, Best Western Seneca-Clemson, Fairfield Inn & Suites Seneca Clemson Univ Area , Fabulous Tiny House with AC in charming Seneca, 6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water., Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock, Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub |
Most Recent Seneca Hotel Reviews

6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.
5 out of 5
Posted 6 days ago
CheapTickets Verified Review
"The location was great with all the right amenities. "
A verified traveler stayed at 6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.
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