Compare Business Hotels in Downtown Des Moines

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Featured Downtown Des Moines Business Hotels

Des Lux Hotel

Des Lux Hotel

3.5 out of 5
800 Locust St Des Moines IA
$149 nightly
The price is $167 total per night
$167 total
Dec 11 - Dec 12
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Des Lux Hotel, you'll be centrally located in Des Moines, a 9-minute walk from Iowa Events Center and 14 minutes by foot from Casey's Center.
Comfort Inn & Suites Event Center

Comfort Inn & Suites Event Center

2.5 out of 5
929 3rd St Des Moines IA
$93 nightly
The price is $104 total per night
$104 total
Dec 14 - Dec 15
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Comfort Inn & Suites Event Center, you'll be centrally located in Des Moines, steps from Iowa Events Center and within a 5-minute walk of Casey's Center.
Pool
Breakfast included
Embassy Suites Hotel Des Moines Downtown

Embassy Suites Hotel Des Moines Downtown

3.5 out of 5
101 E Locust St Des Moines IA
$119 nightly
The price is $134 total per night
$134 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Embassy Suites Hotel Des Moines Downtown in Des Moines (Downtown Des Moines), you'll be a 2-minute drive from Casey's Center and 7 minutes from Iowa State Fairgrounds.
Staybridge Suites Des Moines Downtown by IHG

Staybridge Suites Des Moines Downtown by IHG

3 out of 5
201 E. Locust Street Des Moines IA
$86 nightly
The price is $96 total per night
$96 total
Dec 29 - Dec 30
Total with taxes and fees
Free Cancellation
With a stay at Staybridge Suites Des Moines Downtown by IHG, you'll be centrally located in Des Moines, a 10-minute walk from Iowa Events Center and 11 minutes by foot from Iowa State Capitol Building.
Pool
Hot Tub
Des Moines Marriott Downtown

Des Moines Marriott Downtown

3.5 out of 5
700 Grand Ave Des Moines IA
$135 nightly
The price is $151 total per night
$151 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Des Moines Marriott Downtown, you'll be centrally located in Des Moines, a 2-minute drive from Casey's Center and 8 minutes from Iowa State Fairgrounds.
Hyatt Place Des Moines/Downtown

Hyatt Place Des Moines/Downtown

3 out of 5
418 6th Avenue Des Moines IA
$101 nightly
The price is $113 total per night
$113 total
Dec 14 - Dec 15
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Hyatt Place Des Moines/Downtown, you'll be centrally located in Des Moines, within a 10-minute walk of Iowa Events Center and Des Moines Civic Center.
Pool
Breakfast included
Hampton Inn & Suites Des Moines Downtown

Hampton Inn & Suites Des Moines Downtown

2.5 out of 5
120 Sw Water St Des Moines IA
$87 nightly
The price is $98 total per night
$98 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Hampton Inn & Suites Des Moines Downtown, you'll be centrally located in Des Moines, a 6-minute walk from Principal Park and 11 minutes by foot from Iowa Events Center.
Pool
Breakfast included
Renaissance Des Moines Savery Hotel

Renaissance Des Moines Savery Hotel

3.5 out of 5
401 Locust St Des Moines IA
$135 nightly
The price is $151 total per night
$151 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Renaissance Des Moines Savery Hotel, you'll be centrally located in Des Moines, a 1-minute drive from Casey's Center and 8 minutes from Iowa State Fairgrounds.
Free airport shuttle
Free WiFi
Residence Inn Des Moines Downtown

Residence Inn Des Moines Downtown

3 out of 5
100 SW Water Street Des Moines IA
$96 nightly
The price is $107 total per night
$107 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Residence Inn Des Moines Downtown, you'll be centrally located in Des Moines, a 2-minute drive from Casey's Center and 9 minutes from Iowa State Fairgrounds.
Pool
Hot Tub
Holiday Inn Downtown - Mercy Area by IHG

Holiday Inn Downtown - Mercy Area by IHG

3 out of 5
1050 6th Ave Des Moines IA
$101 nightly
The price is $114 total per night
$114 total
Dec 14 - Dec 15
Total with taxes and fees
Free Cancellation
Holiday Inn Downtown - Mercy Area by IHG is centrally located in Des Moines, a 4-minute walk from Iowa Events Center and 8 minutes by foot from Community Choice Credit Union Convention Center.
Pool
Free airport shuttle
AC Hotel Des Moines East Village

AC Hotel Des Moines East Village

3 out of 5
401 East Grand Ave Des Moines IA
$151 nightly
The price is $169 total per night
$169 total
Dec 20 - Dec 21
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at AC Hotel Des Moines East Village, you'll be centrally located in Des Moines, a 2-minute drive from Casey's Center and 7 minutes from Iowa State Fairgrounds.
Free airport shuttle
Free WiFi
Holiday Inn Express & Suites Des Moines Downtown by IHG

Holiday Inn Express & Suites Des Moines Downtown by IHG

2.5 out of 5
333 SW 11th St Des Moines IA
$89 nightly
The price is $100 total per night
$100 total
Dec 14 - Dec 15
Total with taxes and fees
Free Cancellation
In the heart of Des Moines, Holiday Inn Express & Suites Des Moines Downtown by IHG is within a 5-minute drive of Science Center of Iowa and Casey's Center.
Pool
Hot Tub
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Downtown Des Moines hotels essential information

Accommodation
847 hotels
Lowest Price
$96
Highest Price
$169
Popular hotels
Des Lux Hotel, Comfort Inn & Suites Event Center, Embassy Suites Hotel Des Moines Downtown, Staybridge Suites Des Moines Downtown by IHG, Des Moines Marriott Downtown, Hyatt Place Des Moines/Downtown, Hampton Inn & Suites Des Moines Downtown, Renaissance Des Moines Savery Hotel, Residence Inn Des Moines Downtown, Holiday Inn Downtown - Mercy Area by IHG, AC Hotel Des Moines East Village, Holiday Inn Express & Suites Des Moines Downtown by IHG

Most Recent Downtown Des Moines Hotel Reviews

Des Lux Hotel

Des Lux Hotel

5 out of 5
Posted 2 hours ago
CheapTickets Verified Review
"Clean room, quiet hotel. Beautiful Christmas decorations. Breakfast was great- above and beyond the usual continental breakfast."
A verified traveler stayed at Des Lux Hotel
Des Lux Hotel

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