Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Lowest round trip fares by airline from Portland and Des Moines

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Cheap flights from Portland to Des Moines

Cheap flights from Portland to Des Moines

Are you ready to book your flight, but feeling nervous about paying too much if prices drop in a few days? Don't play the waiting game. Our Best Price Guarantee means if you see a better fare for the same flight, we'll give you the difference in CheapCash, plus $50 more in CheapCash, which you can use to save on your hotel reservation.

If you have a frequent flier account, add it to your reservation to earn miles. And don't worry about getting stuck in a middle seat. Choose your seats when you book, so you'll be right where you want to be on departure day.

Save Even More Time and Money With a Des Moines Travel Package

Once your flights are booked, why start all over again searching for a cheap hotel? Book your flight and hotel together, and save yourself more than time and energy. You'll also be able to take advantage of discounts and coupons on your Des Moines vacation that you can't get when you book flights and hotel separately.

Relax in Des Moines With Confidence and Convenience

Going cheap doesn't mean giving up great service. Our agents are available 24/7 to help you find the right cheap flights and hotel, and to answer questions about your trip.

Need to grab a cheap travel deal while you're on the go? Download our mobile app, where you can search and book just like you would on your home computer. Stay in-the-know on great rates on flights from Portland to Des Moines by signing up for exclusive email deals.

Hotels in Des Moines

See all 166 Properties in Des Moines
Ramada Tropics Resort & Conf Center by Wyndham Des Moines

Ramada Tropics Resort & Conf Center by Wyndham Des Moines

5000 Merle Hay Rd, Urbandale, IA
    3.0 out of 5.0
     
     
    3.3 out of 5 (6 reviews)

    Set in Urbandale, this family-friendly hotel is within 6 mi (10 km) of Buccaneer Arena, Iowa Gold Star Military Museum, and Des Moines Community Playhouse. John ...

    Ramada Tropics Resort & Conf Center by Wyndham Des Moines$65

    Ramada Tropics Resort & Conf Center by Wyndham Des Moines$65
    Wildwood Lodge

    Wildwood Lodge

    11431 Forest Ave, Clive, IA
      3.0 out of 5.0
       
       
      4.5 out of 5 (4 reviews)

      Situated in Clive, this hotel is within 9 mi (15 km) of Pump It Up, Wells Fargo Arena, and Des Moines Public Library. Des Moines Civic Center and Science Center ...

      Wildwood Lodge$85

      Wildwood Lodge$85
      Motel 6 Des Moines West

      Motel 6 Des Moines West

      7655 Office Plaza Dr N, West Des Moines, IA
        2.0 out of 5.0
         
         
        3.1 out of 5 (7 reviews)

        Situated in West Des Moines, this motel is within 3 mi (5 km) of Jordan Creek Town Center, Mercy Medical Center West Lakes, and West Glen Town Center. Clive ...

        Motel 6 Des Moines West$44

        Motel 6 Des Moines West$44
        Hyatt Place Des Moines Downtwn

        Hyatt Place Des Moines Downtwn

        418 6th Avenue, Des Moines, IA
          3.0 out of 5.0
           
           
          4.9 out of 5 (7 reviews)

          Located in Downtown Des Moines, this hotel is within 1 mi (2 km) of Iowa Events Center and Greater Des Moines Botanical Garden. Iowa State Capitol Building is ...

          Hyatt Place Des Moines Downtwn$123

          Hyatt Place Des Moines Downtwn$123
          Holiday Inn Downtown - Mercy Area

          Holiday Inn Downtown - Mercy Area

          1050 6th Ave, Des Moines, IA
            3.0 out of 5.0
             
             
            4.4 out of 5 (5 reviews)

            Located in Downtown Des Moines, this hotel is within a 15-minute walk of Wells Fargo Arena and Iowa Events Center. Science Center of Iowa and Greater Des Moines ...

            Holiday Inn Downtown - Mercy Area$102

            Holiday Inn Downtown - Mercy Area$102
            Hyatt Place West Des Moines Jordan Creek

            Hyatt Place West Des Moines Jordan Creek

            295 64th Street, West Des Moines, IA
              3.0 out of 5.0
               
               

              Situated in a shopping district, this hotel is within 1 mi (2 km) of West Glen Town Center and Jordan Creek Town Center. Valley Stadium and Mercy Medical Center ...

              Hyatt Place West Des Moines Jordan Creek$87

              Hyatt Place West Des Moines Jordan Creek$87
              Days Inn & Suites by Wyndham Des Moines Airport

              Days Inn & Suites by Wyndham Des Moines Airport

              1901 Hackley Ave, Des Moines, IA
                2.0 out of 5.0
                 
                 
                4.1 out of 5 (16 reviews)

                Located in Greater South Side, this hotel is 0.5 mi (0.8 km) from Air Lanes Bowling Center and 2.4 mi (3.8 km) from Blank Park Zoo. Gray’s Lake Park and Fort ...

                Days Inn & Suites by Wyndham Des Moines Airport$70

                Days Inn & Suites by Wyndham Des Moines Airport$70
                La Quinta by Wyndham Altoona Des Moines

                La Quinta by Wyndham Altoona Des Moines

                1785 11th Street NW, Altoona, IA
                   
                   

                  Situated in Altoona, this hotel is 1.1 mi (1.7 km) from Adventureland and 1.9 mi (3 km) from Outlets of Des Moines. Iowa State Fairgrounds and Iowa State Capitol ...

                  La Quinta by Wyndham Altoona Des Moines$56

                  La Quinta by Wyndham Altoona Des Moines$56
                  Stoney Creek Hotel & Conference Center Des Moines

                  Stoney Creek Hotel & Conference Center Des Moines

                  5291 Stoney Creek Court, Johnston, IA
                    2.0 out of 5.0
                     
                     
                    4.8 out of 5 (5 reviews)

                    Situated in the suburbs, this hotel is 2.3 mi (3.7 km) from Pioneer Hi-Bred Headquarters and within 6 mi (10 km) of Iowa Gold Star Military Museum and Buccaneer ...

                    Stoney Creek Hotel & Conference Center Des Moines$100

                    Stoney Creek Hotel & Conference Center Des Moines$100
                    Fairfield Inn and Suites by Marriott Des Moines West

                    Fairfield Inn and Suites by Marriott Des Moines West

                    7225 Vista Dr, West Des Moines, IA
                      2.5 out of 5.0
                       
                       

                      Situated in a shopping district, this hotel is within 3 mi (5 km) of Jordan Creek Town Center, Mercy Medical Center West Lakes, and West Glen Town Center. Clive ...

                      Fairfield Inn and Suites by Marriott Des Moines West$84

                      Fairfield Inn and Suites by Marriott Des Moines West$84
                      Map

                      *Savings based on all holiday package bookings with Flight + Hotel on CheapTickets.com from January through December 2017, as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages. For Free Flight or 100% Off Flight deals, package savings is greater than or equal to the current cost of one component, when both are priced separately.

                      *Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.