Important: This destination may have COVID-19 travel restrictions in place, including specific restrictions for lodging. Check any national, local, and health advisories for this destination before you book.

Cheap flights from Chicago (CHI) to Des Moines (DSM)

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Lowest round trip fares by airline from Chicago and Des Moines

Cheapest prices ($134 One Way, $249 Round Trip) found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Sun, Aug 29
ORD
Chicago
DSM
Des Moines
$134
American Airlines
Sat, Aug 28
MDW
Chicago
DSM
Des Moines
$136
Delta
Tue, Aug 3
ORD
Chicago
DSM
Des Moines
$136
Delta
Sun, Sep 5
ORD
Chicago
DSM
Des Moines
$155
American Airlines
Sat, Jul 10
ORD
Chicago
DSM
Des Moines
$157
American Airlines
Mon, Jul 19 - Tue, Aug 3
ORD
Chicago
DSM
Des Moines
$249
American Airlines
Fri, Jul 30 - Tue, Aug 10
ORD
Chicago
DSM
Des Moines
$249
United
Tue, Aug 17 - Wed, Aug 18
ORD
Chicago
DSM
Des Moines
$261
Bargain Flight
Tue, Aug 17 - Wed, Aug 18
ORD
Chicago
DSM
Des Moines
$268
American Airlines
Mon, Jul 5 - Mon, Jul 12
ORD
Chicago
DSM
Des Moines
$269
United

Great Deals On Cheap Hotels in Des Moines

Motel 6 West Des Moines, IA

Motel 6 West Des Moines, IA

2 out of 5
7655 Office Plaza Dr N, West Des Moines, IA
The price is $54 per night from Jun 29 to Jun 29
Situated in West Des Moines, this motel is within 2 mi (3 km) of Jordan Creek Town Center, UnityPoint Health - Methodist West Hospital, and Mercy Medical Center ...
3/5 (8 reviews)
"Motel 6 was decent. Wish they had microwaves in the room and coffee pot,only had 1 small Microwave down in lobby and no coffee at all very very basic place with clean rooms."

Reviewed on Aug 25, 2020

Motel 6 West Des Moines, IA
Sterling Hotel and Suites

Sterling Hotel and Suites

3 out of 5
11428 Forest Ave, Clive, IA
The price is $84 per night from Jun 22 to Jun 22
Situated in a shopping district, this hotel is within 2 mi (3 km) of Clive Aquatic Center, Living History Farms, and Valley West Mall. Mercy Medical Center West ...
3.9/5Good! (8 reviews)
"Everything was great"

Reviewed on Apr 7, 2021

Sterling Hotel and Suites
Cozy Rest Motel

Cozy Rest Motel

2 out of 5
2316 Southeast 14th Street, Des Moines, IA
The price is $70 per night from Jun 22 to Jun 22
Situated near the airport, this motel is within 3 mi (5 km) of Principal Park, Wells Fargo Arena, and Des Moines Civic Center. Iowa Events Center is 2.7 mi (4.4 ...
3.7/5Good! (3 reviews)
"Nun the workers were completely rude and made me and my family feel very unsafe we would not recommend there at all"

Reviewed on Aug 18, 2019

Cozy Rest Motel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Flights Review

Aug 1, 2018

Cathay Pacific was awesome.

A verified traveler
Chicago to Des Moines · United

Fly From Chicago to Des Moines

Origin Chicago
Destination Des Moines
Number of Daily Flights 38
Earliest Flight Departure Date Jun 28
Latest Flight Departure Date Jun 29
Popular Airlines American Airlines

Cheap flights from Chicago to Des Moines

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Save Even More Time and Money With a Des Moines Travel Package

Once your flights are booked, why start all over again searching for a cheap hotel? Book your flight and hotel together, and save yourself more than time and energy. You'll also be able to take advantage of discounts and coupons on your Des Moines vacation that you can't get when you book flights and hotel separately.

Relax in Des Moines With Confidence and Convenience

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*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.