Compare Cheap Hotels Near Main Street Hyannis Massachusetts

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Cheap lodging near Main Street Hyannis

Hyannis Travel Inn

Hyannis Travel Inn

2.5 out of 5
18 North St Hyannis MA
0.15 mi from Main Street Hyannis
With a stay at Hyannis Travel Inn, you'll be centrally located in Hyannis, just a 4-minute walk from Main Street Hyannis and 6 minutes by foot from John F. Kennedy Hyannis Museum.
Pool
Hot Tub
Fairfield Inn & Suites by Marriott Cape Cod Hyannis

Fairfield Inn & Suites by Marriott Cape Cod Hyannis

2.5 out of 5
867 Iyannough Road Hyannis MA
$101 nightly
The price is $116 total per night
$116 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
1.42 mi from Main Street Hyannis
A stay at Fairfield Inn & Suites by Marriott Cape Cod Hyannis places you in the heart of Hyannis, within a 5-minute drive of Cape Codder Water Park and Summer House Natural Soaps.
Pool
Breakfast included
Courtyard Resort

Courtyard Resort

2 out of 5
125 North St Hyannis MA
$107 nightly
The price is $123 total per night
$123 total
Dec 17 - Dec 18
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.19 mi from Main Street Hyannis
A stay at Courtyard Resort places you in the heart of Hyannis, steps from Main Street Hyannis and 4 minutes by foot from John F. Kennedy Hyannis Museum.
Pool
Hot Tub
Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod

2.5 out of 5
259 Main Street Hyannis MA
$98 nightly
The price is $112 total per night
$112 total
Dec 19 - Dec 20
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.18 mi from Main Street Hyannis
With a stay at Comfort Inn Hyannis - Cape Cod, you'll be centrally located in Hyannis, a 6-minute walk from John F. Kennedy Hyannis Museum and 10 minutes by foot from Hyannis Harbor.
Pool
Hot Tub
Cape Sands Inn

Cape Sands Inn

2.5 out of 5
149 Main St - RT 28 West Yarmouth MA
$69 nightly
The price is $79 total per night
$79 total
Dec 14 - Dec 15
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
1.21 mi from Main Street Hyannis
Located in West Yarmouth, Cape Sands Inn is near the bay, within a 5-minute drive of John F. Kennedy Hyannis Museum and Hyannis Harbor.
Pool
Hot Tub
Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging

3 out of 5
1 South Street Hyannis MA
$165 nightly
The price is $188 total per night
$188 total
Dec 28 - Dec 29
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.4 mi from Main Street Hyannis
Located in Hyannis, Anchor In Distinctive Waterfront Lodging is on the waterfront, within a 5-minute walk of Cape Cod Hospital and Cape Cod Maritime Museum.
Pool
Breakfast included
Hyannis Plaza Hotel

Hyannis Plaza Hotel

2.5 out of 5
662 Main Street Hyannis MA
$82 nightly
The price is $93 total per night
$93 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.54 mi from Main Street Hyannis
A stay at Hyannis Plaza Hotel places you in the heart of Hyannis, steps from Main Street Hyannis and 7 minutes by foot from Cape Cod Melody Tent.
Pool
Parking included
Hyannis Harbor Hotel

Hyannis Harbor Hotel

3.5 out of 5
213 Ocean St Hyannis MA
$160 nightly
The price is $183 total per night
$183 total
Dec 14 - Dec 15
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.39 mi from Main Street Hyannis
With a stay at Hyannis Harbor Hotel, you'll be centrally located in Hyannis, a 10-minute walk from Veterans Memorial Park and 10 minutes by foot from John F. Kennedy Hyannis Museum.
Pool
Hot Tub
Ocean Street Inn on Hyannis Harbor

Ocean Street Inn on Hyannis Harbor

2 out of 5
131 Ocean St Hyannis MA
0.26 mi from Main Street Hyannis
With a stay at Ocean Street Inn on Hyannis Harbor in Hyannis, you'll be near the beach, just a 4-minute walk from Cape Cod Maritime Museum and 6 minutes by foot from Main Street Hyannis.
Free WiFi
Air conditioning
Heritage House Inn on Cape Cod

Heritage House Inn on Cape Cod

2.5 out of 5
540 Old Colony Rd Hyannis MA
0.17 mi from Main Street Hyannis
With a stay at Heritage House Inn on Cape Cod in Hyannis, you'll be within a 5-minute walk of Main Street Hyannis and Cape Cod Maritime Museum.
Pool
Breakfast included
SeaCoast Inn

SeaCoast Inn

2 out of 5
33 Ocean Street Hyannis MA
0.09 mi from Main Street Hyannis
With a stay at SeaCoast Inn in Hyannis, you'll be within a 5-minute walk of Main Street Hyannis and Cape Cod Maritime Museum.
Parking included
Free WiFi
Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis

4 out of 5
287 Iyannough Rd Hyannis MA
$103 nightly
The price is $118 total per night
$118 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.64 mi from Main Street Hyannis
When you stay at Doubletree by Hilton Cape Cod - Hyannis in Hyannis, you'll be near the airport, within a 5-minute drive of John F. Kennedy Hyannis Museum and Hyannis Harbor.
Pool
Parking included
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Main Street Hyannis hotels essential information

Accommodation
3,524 hotels
Lowest Price
$79
Highest Price
$188
Popular hotels
Hyannis Travel Inn, Fairfield Inn & Suites by Marriott Cape Cod Hyannis, Courtyard Resort, Comfort Inn Hyannis - Cape Cod, Cape Sands Inn, Anchor In Distinctive Waterfront Lodging, Hyannis Plaza Hotel, Hyannis Harbor Hotel, Ocean Street Inn on Hyannis Harbor, Heritage House Inn on Cape Cod, SeaCoast Inn, Doubletree by Hilton Cape Cod - Hyannis

Most Recent Main Street Hyannis Hotel Reviews

Courtyard Resort

Courtyard Resort

5 out of 5
Posted 3 days ago
CheapTickets Verified Review
"Room was clean. Only 3 pillows on a King size bed but that wasn't really a big deal... After hours check in was very easy.."
A verified traveler stayed at Courtyard Resort
Courtyard Resort

Types of Hotels

Top 20 Main Street Hyannis Hotels

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