Compare Cheap Hotels Near Main Street Hyannis Massachusetts

Secret Bargains - Save an extra 10% or more on select hotels

Start date: Check-in selected.
To Date
End date: Check-out

Get more for your budget and save up to 50% off select Secret Bargain hotels

Get even more value with CheapTickets Price Guarantee!

Change your flight without a fee on select flights

Cheap lodging near Main Street Hyannis

Courtyard Resort

Courtyard Resort

2 out of 5
125 North St Hyannis MA
$109 nightly
The price is $125 total per night
$125 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.19 mi from Main Street Hyannis
With a stay at Courtyard Resort, you'll be centrally located in Hyannis, within a 5-minute drive of Cape Cod Beaches and Main Street Hyannis.
Pool
Hot Tub
Fairfield Inn & Suites by Marriott Cape Cod Hyannis

Fairfield Inn & Suites by Marriott Cape Cod Hyannis

2.5 out of 5
867 Iyannough Road Hyannis MA
$110 nightly
The price is $125 total per night
$125 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
1.42 mi from Main Street Hyannis
With a stay at Fairfield Inn & Suites by Marriott Cape Cod Hyannis, you'll be centrally located in Hyannis, within a 10-minute drive of Cape Cod Beaches and Cape Codder Water Park.
Pool
Breakfast included
Hyannis Travel Inn

Hyannis Travel Inn

2.5 out of 5
18 North St Hyannis MA
0.15 mi from Main Street Hyannis
With a stay at Hyannis Travel Inn, you'll be centrally located in Hyannis, within a 5-minute drive of Cape Cod Beaches and Main Street Hyannis.
Pool
Hot Tub
Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod

2.5 out of 5
259 Main Street Hyannis MA
$98 nightly
The price is $112 total per night
$112 total
Dec 24 - Dec 25
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.18 mi from Main Street Hyannis
With a stay at Comfort Inn Hyannis - Cape Cod, you'll be centrally located in Hyannis, a 6-minute walk from John F. Kennedy Hyannis Museum and 10 minutes by foot from Hyannis Harbor.
Pool
Hot Tub
Cape Sands Inn

Cape Sands Inn

2.5 out of 5
149 Main St - RT 28 West Yarmouth MA
$75 nightly
The price is $85 total per night
$85 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
1.21 mi from Main Street Hyannis
Located in West Yarmouth, Cape Sands Inn is near the bay, within a 5-minute drive of John F. Kennedy Hyannis Museum and Hyannis Harbor.
Pool
Hot Tub
Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging

3 out of 5
1 South Street Hyannis MA
$168 nightly
The price is $192 total per night
$192 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.4 mi from Main Street Hyannis
When you stay at Anchor In Distinctive Waterfront Lodging in Hyannis, you'll be on the waterfront, within a 15-minute walk of Cape Cod Beaches and Cape Cod Hospital.
Pool
Breakfast included
Hyannis Plaza Hotel

Hyannis Plaza Hotel

2.5 out of 5
662 Main Street Hyannis MA
$82 nightly
The price is $93 total per night
$93 total
Jan 16 - Jan 17, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.54 mi from Main Street Hyannis
With a stay at Hyannis Plaza Hotel, you'll be centrally located in Hyannis, within a 5-minute drive of Cape Cod Beaches and Main Street Hyannis.
Pool
Parking included
Hyannis Harbor Hotel

Hyannis Harbor Hotel

3.5 out of 5
213 Ocean St Hyannis MA
$160 nightly
The price is $183 total per night
$183 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.39 mi from Main Street Hyannis
With a stay at Hyannis Harbor Hotel, you'll be centrally located in Hyannis, a 10-minute walk from Veterans Memorial Park and 10 minutes by foot from John F. Kennedy Hyannis Museum.
Pool
Hot Tub
Ocean Street Inn on Hyannis Harbor

Ocean Street Inn on Hyannis Harbor

2 out of 5
131 Ocean St Hyannis MA
0.26 mi from Main Street Hyannis
When you stay at Ocean Street Inn on Hyannis Harbor in Hyannis, you'll be near the beach, within a 10-minute walk of Cape Cod Beaches and Cape Cod Maritime Museum.
Free WiFi
Air conditioning
Heritage House Inn on Cape Cod

Heritage House Inn on Cape Cod

2.5 out of 5
540 Old Colony Rd Hyannis MA
0.17 mi from Main Street Hyannis
With a stay at Heritage House Inn on Cape Cod in Hyannis, you'll be within a 15-minute walk of Cape Cod Beaches and Main Street Hyannis.
Pool
Breakfast included
SeaCoast Inn

SeaCoast Inn

2 out of 5
33 Ocean Street Hyannis MA
0.09 mi from Main Street Hyannis
With a stay at SeaCoast Inn in Hyannis, you'll be within a 15-minute walk of Cape Cod Beaches and Main Street Hyannis.
Parking included
Free WiFi
Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis

4 out of 5
287 Iyannough Rd Hyannis MA
$103 nightly
The price is $118 total per night
$118 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.64 mi from Main Street Hyannis
When you stay at Doubletree by Hilton Cape Cod - Hyannis in Hyannis, you'll be near the airport, within a 5-minute drive of John F. Kennedy Hyannis Museum and Hyannis Harbor.
Pool
Parking included
Don't see what you're looking for?
See all available properties in Main Street Hyannis
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Often, one of the most difficult things about booking a hotel is finding the best time to go. The cost of staying in hotels in could vary significantly, depending on the time of the year chosen. If you would like to figure out the most suitable time to take a trip then using CheapTickets could be the best option for you. We will be able to provide information on hotels in to ensure that you get the best deal possible. So if you are looking for a booking website that will streamline the process and offer good prices, then log in and get booking.

Main Street Hyannis hotels essential information

Accommodation
3,519 hotels
Lowest Price
$85
Highest Price
$192
Popular hotels
Courtyard Resort, Fairfield Inn & Suites by Marriott Cape Cod Hyannis, Hyannis Travel Inn, Comfort Inn Hyannis - Cape Cod, Cape Sands Inn, Anchor In Distinctive Waterfront Lodging, Hyannis Plaza Hotel, Hyannis Harbor Hotel, Ocean Street Inn on Hyannis Harbor, Heritage House Inn on Cape Cod, SeaCoast Inn, Doubletree by Hilton Cape Cod - Hyannis

Most Recent Main Street Hyannis Hotel Reviews

Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod

5 out of 5
Posted 2 days ago
CheapTickets Verified Review
"Nice hotel had a perfect stay"
A verified traveler stayed at Comfort Inn Hyannis - Cape Cod
Comfort Inn Hyannis - Cape Cod

Types of Hotels

Top 20 Main Street Hyannis Hotels

Hotels Near Main Street Hyannis

Cities near Main Street Hyannis