Compare Cheap Hotels in East Prairie

Secret Bargains - Save an extra 10% or more on select hotels

Start date: Check-in selected.
To Date
End date: Check-out

Get more for your budget and save up to 50% off select Secret Bargain hotels

Get even more value with CheapTickets Price Guarantee!

Change your flight without a fee on select flights

Cheap East Prairie Hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$90 nightly
The price is $103 total per night
$103 total
Dec 23 - Dec 24
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
11.41 mi from city center
A stay at Drury Inn & Suites Sikeston, MO places you in the heart of Sikeston, a 1-minute drive from City of Miner Convention Center and 5 minutes from Sikeston Depot Museum.
Pool
Breakfast included
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
$98 nightly
The price is $110 total per night
$110 total
Dec 28 - Dec 29
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
12.05 mi from city center
When you stay at Hampton Inn Sikeston in Sikeston, you'll be near the airport, within a 5-minute drive of Central Park and Sikeston Depot Museum.
Pool
Breakfast included
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

2.5 out of 5
1111 BLue Heron Lane Union City TN
$76 nightly
The price is $90 total per night
$90 total
Jan 8 - Jan 9, 2026
Total with taxes and fees
Free Cancellation
29.52 mi from city center
Located in Union City, Sleep Inn at Discovery Park of America is within a 5-minute drive of Discovery Park of America and Union City Masquerade Theatre.
Pool
Breakfast included
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive Sikeston MO
$76 nightly
The price is $86 total per night
$86 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
11.14 mi from city center
Located in Sikeston, Best Western Plus Sikeston is a 2-minute drive from City of Miner Convention Center and 6 minutes from Sikeston Depot Museum.
Pool
Breakfast included
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue Sikeston MO
$75 nightly
The price is $86 total per night
$86 total
Dec 23 - Dec 24
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
11.38 mi from city center
A stay at Pear Tree Inn Sikeston places you in the heart of Sikeston, just a 4-minute walk from City of Miner Convention Center and within a 5-minute drive of Sikeston Depot Museum.
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
$63 nightly
The price is $72 total per night
$72 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
11.02 mi from city center
Located in Sikeston, Days Inn and Suites by Wyndham Sikeston is a 3-minute drive from City of Miner Convention Center and 7 minutes from Sikeston Depot Museum.
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
$55 nightly
The price is $63 total per night
$63 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
11.3 mi from city center
Located in Sikeston, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) is in a rural location, within a 5-minute drive of City of Miner Convention Center and Sikeston Depot Museum.
Breakfast included
Pet friendly
Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51

2.5 out of 5
1221 W Reelfoot Ave Union City TN
$54 nightly
The price is $65 total per night
$65 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
30.56 mi from city center
With a stay at Hospitality House Union City I 69 / US 51 in Union City, you'll be within a 5-minute drive of Reelfoot Shopping Center and County Market Place.
Pool
Breakfast included
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

2.5 out of 5
1239 Commerce Drive Sikeston MO
$101 nightly
The price is $114 total per night
$114 total
Dec 25 - Dec 26
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
12.36 mi from city center
With a stay at Fairfield Inn & Suites by Marriott Sikeston in Sikeston, you'll be within a 5-minute drive of Central Park and Sikeston Depot Museum.
Hampton Inn Union City

Hampton Inn Union City

2.5 out of 5
2121 W REELFOOT AVE Union City TN
$98 nightly
The price is $116 total per night
$116 total
Dec 26 - Dec 27
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
30.77 mi from city center
With a stay at Hampton Inn Union City in Union City, you'll be within a 5-minute drive of County Market Place and Reelfoot Shopping Center.
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
$59 nightly
The price is $68 total per night
$68 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
11.47 mi from city center
With a stay at Super 8 by Wyndham Sikeston/Miner Area in Sikeston, you'll be within a 5-minute drive of City of Miner Convention Center and Sikeston Depot Museum.
For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.

For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.

Hornbeak TN
$426 nightly
The price is $478 total per night
$478 total
Dec 22 - Dec 23
Total with taxes and fees
29.08 mi from city center
With a stay at this lodge in Hornbeak, you'll be on the waterfront, just steps from Reelfoot Lake and a 5-minute drive from Campbell's Point.
Don't see what you're looking for?
See all available properties in East Prairie
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Often, one of the most difficult things about booking a hotel is finding the best time to go. The cost of staying in hotels in could vary significantly, depending on the time of the year chosen. If you would like to figure out the most suitable time to take a trip then using CheapTickets could be the best option for you. We will be able to provide information on hotels in to ensure that you get the best deal possible. So if you are looking for a booking website that will streamline the process and offer good prices, then log in and get booking.

East Prairie hotels essential information

Accommodation
84 hotels
Lowest Price
$63
Highest Price
$478
Popular hotels
Drury Inn & Suites Sikeston, MO, Hampton Inn Sikeston, Sleep Inn at Discovery Park of America, Best Western Plus Sikeston, Pear Tree Inn Sikeston, Days Inn and Suites by Wyndham Sikeston, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67), Hospitality House Union City I 69 / US 51, Fairfield Inn & Suites by Marriott Sikeston, Hampton Inn Union City, Super 8 by Wyndham Sikeston/Miner Area, For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.