See all 3139 hotels in South Carolina Midlands
- Hilton Garden Inn Columbia/Harbison
- Tru By Hilton Columbia Downtown
- La Quinta Inn & Suites by Wyndham Florence
- Doubletree by Hilton Columbia, SC
- Hampton Inn & Suites Florence Center
- Marriott Columbia
- Delta Hotels by Marriott Columbia Northeast
- Woodspring Suites Columbia - Irmo
- Days Inn by Wyndham Florence Near Civic Center
- Hampton Inn Columbia-I-26 Airport
- Hampton Inn Santee-I-95