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Lowest round trip fares by airline from San Francisco and Santiago

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Cheap flights from San Francisco to Santiago

Cheap flights from San Francisco to Santiago

Guests flying to the Comodoro Arturo Merino Benítez International Airport (SCL) in Santiago, Chile, for business or leisure, will get an immediate introduction to local culture at the Plaza de Armas. The many points of interest here include the Catedral Metropoolitana de Santiago, the Museo de Arte Sagrado and the Museo Historico Nacional. You’ll also catch street entertainers performing here daily, and artwork created by local artists lines the streets.

Key Facts

When you take advantage of a rental vehicle, you'll leave the airport via the Vespucio Nte Expressway and take either Highway 5 or 68 into the city, where soccer remains a popular sport. Santiago has three teams that regularly play matches, which provides visitors with the chance to experience the excitement at a live game.

Sample local popular dishes that include a version of shepherd's pie, veggie-topped burgers or hotdogs. Enjoy the taste of a terrmoto, which consists of grape liquor, sweet wine and pineapple ice cream.

Hints and Tips

Flying from the San Francisco International Airport (SFO) to Santiago takes approximately 12 and a half hours. Near the city, wine lovers might visit the Vina Concha y Toro, or the Vinas Cousino Macul and Aquitania. Take a pleasant drive into the countryside, tour a winery and taste the vintages produced at one of the many Casablanca Valley facilities.

Hotels in Santiago

See all 1,118 Properties in Santiago
Holiday Inn Santiago - Airport Terminal

Holiday Inn Santiago - Airport Terminal

Armando Cortinez Norte 2150, Santiago, Region Metropolitana
    3.5 out of 5.0
     
     
    4.2 out of 5 (5 reviews)

    Conveniently located near the ski slopes, this Pudahuel hotel is within 12 mi (20 km) of Templo Votivo de Maipu, Mall Plaza Oeste, and Mercado Central. Paseo ...

    Holiday Inn Santiago - Airport Terminal$124

    Holiday Inn Santiago - Airport Terminal$124
    Hyatt Place Santiago/Vitacura

    Hyatt Place Santiago/Vitacura

    Avenida Americo Vespucio Norte 1597, Vitacura, Santiago, Region Metropolitana
      3.5 out of 5.0
       
       
      5.0 out of 5 (1 reviews)

      Situated in Santiago, this hotel is 0.7 mi (1.1 km) from Parque Arauco Mall and 1.9 mi (3.1 km) from Costanera Center. Casacostanera and Bicentennial Park are ...

      Hyatt Place Santiago/Vitacura$99

      Hyatt Place Santiago/Vitacura$99
      Hilton Garden Inn Santiago Airport

      Hilton Garden Inn Santiago Airport

      Americo Vespucio Ave 1292, Pudahuel, Santiago, Region Metropolitana
        3.5 out of 5.0
         
         

        Conveniently located near the ski slopes, this Pudahuel hotel is within 9 mi (15 km) of Templo Votivo de Maipu, O'Higgins Park, and Mall Plaza Oeste. Fantasilandia ...

        Hilton Garden Inn Santiago Airport$98

        Hilton Garden Inn Santiago Airport$98
        ICON Hotel

        ICON Hotel

        Av. Alonso de Cordova 6050, Las Condes, Santiago
          4.0 out of 5.0
           
           

          Situated in the business district, this spa hotel is within 1 mi (2 km) of Apumanque and Parque Arauco Mall. Pueblito Los Dominicos and Alto Las Condes are also ...

          ICON Hotel$94

          ICON Hotel$94
          Hyatt Centric Las Condes Santiago

          Hyatt Centric Las Condes Santiago

          Enrique Foster 30, Santiago
            4.5 out of 5.0
             
             

            Located in the heart of Santiago, this luxury hotel is within a 15-minute walk of Peru Plaza and Costanera Center. Bicentennial Park and La Chascona are also ...

            Hyatt Centric Las Condes Santiago$184

            Hyatt Centric Las Condes Santiago$184
            Ibis Budget Santiago Providencia (Opening August 2019)

            Ibis Budget Santiago Providencia (Opening August 2019)

            AVENIDA MANUEL MONTT 240, Santiago
              3.0 out of 5.0
               
               

              Situated in Santiago, this hotel is 0.2 mi (0.3 km) from Nescafé Theater of The Arts and within 3 mi (5 km) of Costanera Center and Santiago Town Square. Plaza ...

              Ibis Budget Santiago Providencia (Opening August 2019)$48

              Ibis Budget Santiago Providencia (Opening August 2019)$48
              Hotel Diego de Almagro Aeropuerto - Santiago

              Hotel Diego de Almagro Aeropuerto - Santiago

              Avda. Américo Vespucio Oriente, 1299, Santiago, Region Metropolitana
                3.5 out of 5.0
                 
                 
                4.5 out of 5 (2 reviews)

                Located in Pudahuel, this hotel is within 9 mi (15 km) of Templo Votivo de Maipu, University of Santiago-Chile, and Mall Plaza Oeste. Plaza de la Constitucion ...

                Hotel Diego de Almagro Aeropuerto - Santiago$85

                Hotel Diego de Almagro Aeropuerto - Santiago$85
                Hotel Plaza El Bosque Nueva Las Condes

                Hotel Plaza El Bosque Nueva Las Condes

                Av. Manquehue 656, Las Condes, Santiago, Region Metropolitana
                  4.0 out of 5.0
                   
                   
                  4.5 out of 5 (4 reviews)

                  Situated in the business district, this hotel is within a 15-minute walk of KidZania Santiago and Parque Arauco Mall. Costanera Center and Palacio de la Moneda ...

                  Hotel Plaza El Bosque Nueva Las Condes$93

                  Hotel Plaza El Bosque Nueva Las Condes$93
                  Altura Suites

                  Altura Suites

                  Huérfanos 549, Belles Artes, Santiago, Region Metropolitana
                    3.0 out of 5.0
                     
                     
                    3.3 out of 5 (3 reviews)

                    Located near the slopes, this Downtown Santiago apartment building is in the city center and within a 10-minute walk of Santa Lucia Hill, Santiago Town Square, ...

                    Altura Suites$38

                    Altura Suites$38
                    Hotel Cumbres Lastarria

                    Hotel Cumbres Lastarria

                    Jose Victorino Lastarria 299, Santiago, Region Metropolitana
                      4.0 out of 5.0
                       
                       

                      Located in Lastarria, this hotel is within a 15-minute walk of Lastarria District, Santiago Town Square, and Plaza de Armas. Plaza de la Constitucion and Palacio ...

                      Hotel Cumbres Lastarria$209

                      Hotel Cumbres Lastarria$209
                      Map

                      *Savings based on all holiday package bookings with Flight + Hotel on CheapTickets.com from January through December 2017, as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages. For Free Flight or 100% Off Flight deals, package savings is greater than or equal to the current cost of one component, when both are priced separately.

                      *Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.