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Lowest round trip fares by airline from Quito and Santiago

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Cheap flights from Quito to Santiago

Cheap flights from Quito to Santiago

Are you ready to book your flight, but feeling nervous about paying too much if the price drops? Don't play the waiting game. Our Best Price Guarantee means if you see a better fare for the same flight, we'll give you the difference in CheapCash, plus a $50 CheapCash bonus, which you can use to save on your hotel reservation.

If you have a frequent flier account, add it to your reservation to earn miles. And don't worry about getting stuck in a middle seat. Choose your seats when you book, so you'll be right where you want to be on departure day.

Save Even More Time and Money With a Santiago Travel Package

Once your flights are booked, why start all over again searching for a cheap hotel? Book your flight and hotel together, and save yourself more than time and energy. You'll also be able to take advantage of discounts and coupons on your Santiago vacation that you can't get when you book flights and hotel separately.

Relax in Santiago With Confidence and Convenience

Going cheap doesn't mean giving up great service. Our agents are available 24/7 to help you find the right cheap flights and hotel, and to answer questions about your trip.

Need to grab a cheap travel deal while you're on the go? Download our mobile app, where you can search and book just like you would on your home computer. Stay in-the-know on great rates on flights from Quito to Santiago by signing up for exclusive email deals.

Hotels in Santiago

See all 912 Properties in Santiago
Holiday Inn Santiago - Airport Terminal

Holiday Inn Santiago - Airport Terminal

Armando Cortinez Norte 2150, Santiago, Region Metropolitana
    3.5 out of 5.0
     
     
    4.2 out of 5 (5 reviews)

    Located in Pudahuel, this hotel is within 12 mi (20 km) of Templo Votivo de Maipu, Plaza de la Constitucion, and Santiago Town Square. Palacio de la Moneda and ...

    Holiday Inn Santiago - Airport Terminal$133

    Holiday Inn Santiago - Airport Terminal$133
    Hotel Plaza El Bosque Nueva Las Condes

    Hotel Plaza El Bosque Nueva Las Condes

    Av. Manquehue 656, Las Condes, Santiago, Region Metropolitana
      4.0 out of 5.0
       
       
      4.5 out of 5 (2 reviews)

      Situated in the business district, this hotel is within a 15-minute walk of KidZania Santiago and Parque Arauco Mall. Costanera Center and Palacio de la Moneda ...

      Hotel Plaza El Bosque Nueva Las Condes$93

      Hotel Plaza El Bosque Nueva Las Condes$93
      La Quinta by Wyndham Santiago Aeropuerto

      La Quinta by Wyndham Santiago Aeropuerto

      Av. Americo Vespucio 1284, Santiago, Santiago
        4.0 out of 5.0
         
         

        Located in Pudahuel, this hotel is within 9 mi (15 km) of Templo Votivo de Maipu, University of Santiago-Chile, and Museo Ferroviario. Museum of Memory and Human ...

        La Quinta by Wyndham Santiago Aeropuerto$81

        La Quinta by Wyndham Santiago Aeropuerto$81
        Hyatt Place Santiago/Vitacura

        Hyatt Place Santiago/Vitacura

        Avenida Americo Vespucio Norte 1597, Vitacura, Santiago, Region Metropolitana
          3.5 out of 5.0
           
           
          5.0 out of 5 (1 reviews)

          Situated in Santiago, this hotel is 0.7 mi (1.1 km) from Parque Arauco Mall and 1.9 mi (3.1 km) from Costanera Center. Casacostanera and Bicentennial Park are ...

          Hyatt Place Santiago/Vitacura$94

          Hyatt Place Santiago/Vitacura$94
          ICON Hotel

          ICON Hotel

          Av. Alonso de Cordova 6050, Las Condes, Santiago
            4.0 out of 5.0
             
             

            Situated in the business district, this spa hotel is within 1 mi (2 km) of Apumanque and Parque Arauco Mall. Pueblito Los Dominicos and Alto Las Condes are also ...

            ICON Hotel$91

            ICON Hotel$91
            DoubleTree by Hilton Hotel Santiago - Vitacura

            DoubleTree by Hilton Hotel Santiago - Vitacura

            Avenida Vitacura 2727, Las Condes, Santiago, Region Metropolitana
              4.0 out of 5.0
               
               

              Located in the heart of Santiago, this hotel is within 1 mi (2 km) of Gran Torre Santiago and Costanera Center. Peru Plaza and Vivo Panorámico are also within ...

              DoubleTree by Hilton Hotel Santiago - Vitacura$76

              DoubleTree by Hilton Hotel Santiago - Vitacura$76
              Hotel Diego de Almagro Aeropuerto - Santiago

              Hotel Diego de Almagro Aeropuerto - Santiago

              Avda. Américo Vespucio Oriente, 1299, Santiago, Region Metropolitana
                3.5 out of 5.0
                 
                 
                4.5 out of 5 (2 reviews)

                Located in Pudahuel, this hotel is within 9 mi (15 km) of Templo Votivo de Maipu, University of Santiago-Chile, and Mall Plaza Oeste. Plaza de la Constitucion ...

                Hotel Diego de Almagro Aeropuerto - Santiago$70

                Hotel Diego de Almagro Aeropuerto - Santiago$70
                Hyatt Centric Las Condes Santiago

                Hyatt Centric Las Condes Santiago

                Enrique Foster 30, Santiago
                  4.5 out of 5.0
                   
                   

                  Located in the heart of Santiago, this luxury hotel is within a 15-minute walk of Peru Plaza and Costanera Center. Bicentennial Park and La Chascona are also ...

                  Hyatt Centric Las Condes Santiago$170

                  Hyatt Centric Las Condes Santiago$170
                  W Santiago

                  W Santiago

                  Isidora Goyenechea 3000, Las Condes, Santiago, Region Metropolitana
                    5.0 out of 5.0
                     
                     
                    5.0 out of 5 (1 reviews)

                    Situated in the business district, this luxury hotel is within a 15-minute walk of Peru Plaza and Costanera Center. Los Leones Golf Club and Gran Torre Santiago ...

                    W Santiago$167

                    W Santiago$167
                    City Express Santiago Aeropuerto

                    City Express Santiago Aeropuerto

                    Av. Américo Vespucio Oriente 1295, Pudahuel, Santiago
                      3.0 out of 5.0
                       
                       

                      Located in Pudahuel, this hotel is within 9 mi (15 km) of Museo Ferroviario, National Museum of Natural History, and Templo Votivo de Maipu. Parque Quinta Normal ...

                      City Express Santiago Aeropuerto$84

                      City Express Santiago Aeropuerto$84
                      Map

                      *Savings based on all holiday package bookings with Flight + Hotel on CheapTickets.com from January through December 2017, as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages. For Free Flight or 100% Off Flight deals, package savings is greater than or equal to the current cost of one component, when both are priced separately.

                      *Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.