Compare Business Hotels in Syracuse

Secret Bargains - Save an extra 10% or more on select Business Hotels

Get more for your budget and save up to 50% off select Secret Bargain hotels

Get even more value with CheapTickets Price Guarantee!

Change your flight without a fee on select flights

Featured Syracuse Business Hotels

Mercure Siracusa Prometeo

Viale Teracati 20 Syracuse SR

$102 nightly

$128 total

Dec 14 - Dec 15

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

A stay at Mercure Siracusa Prometeo places you in the heart of Syracuse, within a 5-minute walk of Roman Amphitheatre of Syracuse and San Nicolo dei Cordari.

Hotel Panorama

Via Necropoli Grotticelle 33 Syracuse SR

$85 nightly

$97 total

Jan 2 - Jan 3, 2026

Total with taxes and fees

Located in Syracuse (Neapolis), Hotel Panorama is within a 5-minute drive of Roman Amphitheatre of Syracuse and Rope-makers' Cave.

Addauro Resort

Contrada Torre Milocca S/N Syracuse SR

When you stay at Addauro Resort in Syracuse, you'll be near the beach, within a 5-minute drive of Ionian Sea and Arenella Beach.

Alla Giudecca

Via Alagona 52, Ortigia Syracuse SR

Free Cancellation

Reserve now, pay when you stay

With a stay at Alla Giudecca in Syracuse (Ortigia), you'll be steps from Jewish Bath and Museum of Cinema.

Dolce by Wyndham Siracusa I Monasteri Golf & Spa

Traversa Monasteri Di Sotto, 3 Syracuse SR

$103 nightly

$117 total

Jan 6 - Jan 7, 2026

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

When you stay at Dolce by Wyndham Siracusa I Monasteri Golf & Spa in Syracuse, you'll be within a 5-minute drive of Museum Etnografico Nunzio Bruno.

Palazzo Artemide - VRetreats

Via Roma 66 Syracuse SR

$215 nightly

$248 total

Dec 19 - Dec 20

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

With a stay at Palazzo Artemide - VRetreats, SLH Collection, you'll be centrally located in Syracuse, steps from Cathedral of Syracuse and Piazza del Duomo.

Borgo Pantano

Traversa Fontana Mortella, 13 int. 4 Syracuse SR

Located in Syracuse, Borgo Pantano is in a rural location, within a 10-minute drive of Roman Amphitheatre of Syracuse and San Nicolo dei Cordari.

Casale Milocca

Traversa Case Troia 13 Syracuse Sicily

With a stay at Casale Milocca in Syracuse, you'll be within a 15-minute walk of Fanusa Beach and Ionian Sea.

Case Damma

Via Per Canicattini 28 Syracuse SR

Free Cancellation

Reserve now, pay when you stay

Located in Syracuse, Case Damma is in the suburbs, within a 15-minute drive of Museum Etnografico Nunzio Bruno and Roman Amphitheatre of Syracuse.

Grand Hotel Des Ètrangers - The Leading Hotels of the World

Passeggio Adorno 10/12 Syracuse SR

With a stay at Grand Hotel Des Ètrangers - The Leading Hotels of the World in Syracuse (Ortigia), you'll be steps from Tropical Aquarium of Syracuse and Fonte Aretusa.

Domus Mariae Albergo

Via Vittorio Veneto 76 Syracuse SR

$137 nightly

$157 total

Dec 19 - Dec 20

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

With a stay at Domus Mariae Albergo in Syracuse (Ortigia), you'll be steps from Lungomare di Ortigia and Ionian Sea.

Domus Mariae Benessere

Via Vittorio Veneto, 89 Syracuse SR

With a stay at Domus Mariae Benessere in Syracuse (Ortigia), you'll be steps from Lungomare di Ortigia and Ionian Sea.

Don't see what you're looking for?

See all available properties in Syracuse

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Often, one of the most difficult things about booking a hotel is finding the best time to go. The cost of staying in hotels in could vary significantly, depending on the time of the year chosen. If you would like to figure out the most suitable time to take a trip then using CheapTickets could be the best option for you. We will be able to provide information on hotels in to ensure that you get the best deal possible. So if you are looking for a booking website that will streamline the process and offer good prices, then log in and get booking.

Syracuse hotels essential information

Accommodation	2,166 hotels
Lowest Price	$97
Highest Price	$248
Popular hotels	Mercure Siracusa Prometeo, Hotel Panorama, Addauro Resort, Alla Giudecca, Dolce by Wyndham Siracusa I Monasteri Golf & Spa, Palazzo Artemide - VRetreats, Borgo Pantano, Casale Milocca, Case Damma, Grand Hotel Des Ètrangers - The Leading Hotels of the World, Domus Mariae Albergo, Domus Mariae Benessere