Entire home

Luxurious couples retreat just steps from Historic Main Street in St. Charles!

Choose dates to view prices

Photo gallery for Luxurious couples retreat just steps from Historic Main Street in St. Charles!

Outdoor dining
Interior
Exterior
Spa
1 bedroom, iron/ironing board, free WiFi, bed sheets

Reviews

10 out of 10
Exceptional

Entire home

1 bedroom1 bathroomSleeps 3800 sq ft

Popular amenities

  • Kitchen
  • Washer
  • Dryer
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
Saint Charles, MO
  • Place, Historic Main Street
    ‪1 min walk‬
  • Place, Lewis & Clark Boathouse and Nature Center
    ‪3 min walk‬
  • Place, Ameristar Casino St. Charles
    ‪12 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪10 min drive‬

Room options

Similar properties

About the neighborhood

St. Charles

With a stay at this vacation home, you'll be centrally located in St. Charles, a 2-minute drive from Ameristar Casino St. Charles and 6 minutes from Hollywood Casino Amphitheatre. .This vacation home is 12.4 mi (19.9 km) from Mississippi River and 17.5 mi (28.1 km) from Saint Louis Galleria Mall.

What's nearby

  • Historic Main Street - 1 min walk - 0.0 miles
  • Frontier Park - 2 min walk - 0.1 miles
  • Lewis & Clark Boathouse and Nature Center - 3 min walk - 0.2 miles
  • Ameristar Casino St. Charles - 12 min walk - 0.7 miles
  • St Charles Convention Center - 3 min drive - 1.3 miles

Getting around

  • Kirkwood Station - 24 min drive
  • St. Louis Lambert Intl. Airport (STL) - 12 min drive

Restaurants

  • ‪McDonald's - ‬11 min walk
  • ‪Llywelyn's Pub - ‬10 min walk
  • ‪Starbucks - ‬8 min walk
  • ‪Waffle House - ‬11 min walk
  • ‪Salt + Smoke - ‬5 min walk

About this property

Entire place

You'll have the entire home to yourself and will only share it with other guests in your party.

Luxurious couples retreat just steps from Historic Main Street in St. Charles!

The Lewis & Clark Guest House is a historic cottage that has been thoughtfully remodeled into a luxurious retreat while still keeping the feel of its colonial heritage- perfect for a romantic getaway or small group. This charming home was built in 1793 and once owned by the Commandant of St. Charles, Don Carlos Tayon. He lived here when Merriwether Lewis and William Clark arrived and met with him presumably in this house! The main entrance opens into a gorgeous master bedroom with king, 4 post bed, quality linens, and down comforter. From the bed you can view the large stone and brick hearth with gas flame stove, perfect for snuggling up on a chilly night. There is also two upholstered sitting chairs and a table for relaxing or reading and taking your morning coffee. A flat screen TV, and armoire are also included for your convenience.
A set of lovely double doors leads you into an amazingly luxurious and unique master bathroom. Stone steps lead you up to the oversized raised jetted tub with brick surround. Adjacent to that is the expansive tiled shower complete with two sets of shower systems including multiple rainfall shower heads and body sprayers. From the tub and the shower, you can see another fireplace set into a stone hearth and an additional flat screen tv above it. Also in the suite is a separate room with the toilet, an antique dresser made into the vanity, and large capacity washer/dryer behind two doors.
Off the back of the bedroom is a charming sitting room with a built in seating area with a twin mattress and numerous soft pillows for the ultimate comfort in lounging or extra sleeping space if needed. There is an additional tv in this room as well for viewing from your cozy retreat.
From there you can see into the adorable kitchen with white washed brick walls, and cabinets the same lovely dark grey green color that is carried throughout the home. Amply outfitted with high end appliances, this full kitchen make dining in a joy. Custom built in bench with antique table for eating, and a coffee bar complete with a Keurig coffee machine, frother, and variety of k-cups for your enjoyment.
Head outside with your morning coffee to the beautiful fully privacy-fenced backyard. The historic brick patio welcomes you with comfortable seating amd tiki torches. You sit out under the enormous tulip tree, and enjoy the evening, cuddling by the fires.
Of course, when you want to leave your spa-like oasis, Main Street and all the unique shops and fantastic eating establishments, Katy trail, parks and more are only steps away. You can spend many days exploring all it has to offer, and when you have done all that, we are a short half hour drive to downtown St. Louis and the never-ending attractions that await you there. We would love to have you stay with us at the Lewis & Clark Guest House!
Make yourself comfortable in this air-conditioned vacation home, which features a fireplace and a Smart TV. There's a private patio. A kitchen is outfitted with a refrigerator, an oven, and a stovetop. Complimentary wireless internet access is available to keep you connected. The bathroom has a jetted bathtub and a hair dryer.
Enjoy recreational amenities such as a water park and a hot tub.
Guests will find features like internet access and onsite parking.

Property amenities

Pool/Spa

  • Hot tub

Internet

  • Available in the house: Free WiFi

Parking and transportation

  • Car recommended
  • Parking on site

Kitchen

  • Coffee/tea maker
  • Cookware, dishware, and utensils
  • Dishwasher
  • Ice maker
  • Microwave
  • Oven
  • Refrigerator
  • Stovetop
  • Toaster

Dining

  • Dining table

Bedrooms

  • Bedroom
  • Bedsheets provided

Bathroom

  • 1 bathroom
  • Hair dryer
  • Jetted bathtub
  • Shower
  • Towels provided

Living spaces

  • Dining table
  • Fireplace

Entertainment

  • Books
  • Games
  • Smart TV

Outdoor areas

  • Barbecue grill
  • Fenced yard
  • Firepit
  • Garden
  • Patio

Laundry

  • Laundry facilities
  • Washing machine

Comfort

  • Air conditioning
  • Heating

Pets

  • No pets allowed

Suitability/Accessibility

  • Smoking not allowed

Services and conveniences

  • Iron/ironing board

Location highlights

  • In the city center
  • Near a health/beauty spa
  • Near a hospital
  • Near a zoo
  • Near an outlet shopping mall

Things to do

  • Water park
  • Birdwatching nearby
  • Casino nearby
  • Fishing nearby
  • Golfing nearby
  • Hiking/biking trails nearby
  • Motor boating nearby
  • Mountain biking nearby
  • Theme park nearby
  • Wildlife walks nearby
  • Winery tours nearby

Safety features

  • Carbon monoxide detector (host has indicated there is a carbon monoxide detector on the property)
  • Smoke detector (host has indicated there is a smoke detector on the property)
  • First aid kit
  • Fire extinguisher
  • Deadbolt lock

General

  • Garden
  • Unit size: 800 square feet

Policies

Check-in

Check-in time starts at 4:00 PM
Contactless check-in available
Minimum check-in age: 25

Check-out

Check-out before 11:00 AM

Special check-in instructions

You will receive an email from the host with check-in and check-out instructions
Information provided by the property may be translated using automated translation tools

Rules

Must sign rental agreement within 48 hours upon booking
A $300 security hold will be placed 2 days prior to arrival and released 7 days after departure, if no damages are reported
Must follow all house rules including but not limited to no pets, no smoking, and no parties. Minimum age of 25 years old to book.

Pets

Pets not allowed

Children and extra beds

Children are welcome
Note from host: One child could sleep on the sitting room bed

Events

No events allowed
We do not allow parties of any kind including bach

Smoking

Smoking is not permitted

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
Onsite parties or group events are strictly prohibited
Note from host: We do not allow parties of any kind including bach
Host has indicated there is a carbon monoxide detector on the property
Host has indicated there is a smoke detector on the property
Safety features at this property include a fire extinguisher, a first aid kit, and a deadbolt lock
This property is managed through our partner, Vrbo. You will receive an email from Vrbo with a link to a Vrbo account, where you can change or cancel your reservation

We should mention

A car is recommended for transportation to and from this property

Property is also known as

orp5b5efc4x

Luxurious couples retreat just steps from Historic Main Street in St. Charles! Reviews

Reviews

10

Exceptional

Rating 10 - Excellent. 99 out of 99 reviews
Rating 8 - Good. 0 out of 99 reviews
Rating 6 - Okay. 0 out of 99 reviews
Rating 4 - Poor. 0 out of 99 reviews
Rating 2 - Terrible. 0 out of 99 reviews

10/10

Cleanliness

Reviews

Verified

10/10 Excellent

Kristin P.

Liked: Cleanliness, check-in, communication, location, listing accuracy
One of our favorite places to stay for a long weekend away.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Patricia N.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Yes, they were very nice throughout all the process. The house was very nice. Hoping to go back!
Stayed 2 nights in Feb 2026
Verified

10/10 Excellent

laura e.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Audrey and Matt always provide an excellent stay
Stayed 4 nights in Sep 2025
Verified

10/10 Excellent

Jessica B.

Liked: Cleanliness, check-in, communication, location, listing accuracy
This is the cleanest property I have ever stayed in. Beautifully designed cottage steps away from Main St. We loved the ease of the gas fireplace, which heated up the cottage quickly. The bed and sheets were so comfortable. They had the place perfectly decorated for Christmas. We would stay here again.
Stayed 2 nights in Dec 2025
From a partner site

10/10 Excellent

Richard L.

Outstanding!!

This is an absolutely marvelous property. It's an historic building, remodeled in great taste to modern specifications. Even being past 70 years of age, the steps are well worth climbing! The location and corresponding ability to stroll historic Old Town St. Charles makes it a perfect choice. It's close enough to explore the town and even return for a short nap without missing a beat. Highly recommended.
Verified

10/10 Excellent

Stacey J.

Liked: Cleanliness, check-in, communication, location, listing accuracy
This cottage is EVERYTHING!!! The coziest romantic getaway you could ask for!
Stayed 2 nights in Oct 2025
Verified

10/10 Excellent

Brian S.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Great weekend stay

Had a great weekend getaway
Stayed 3 nights in Jan 2025
Verified

10/10 Excellent

Shealyn H.

Liked: Cleanliness, check-in, communication, location, listing accuracy
The house was adorable and cozy, perfect for two. Being right off main Street was so much fun. So much to do! The owners were helpful and kind. We absolutely loved our stay!
Stayed 3 nights in Jul 2025
Verified

10/10 Excellent

Lisa C.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Guest House

Very clean, very comfortable, well maintained.
Stayed 4 nights in May 2025
Verified

10/10 Excellent

Kim W.

Liked: Cleanliness, check-in, communication, location, listing accuracy
This was literally the perfect post-wedding retreat. The space is charming, romantic, and cozy. Not to mention you’re basically right on Main Street, so we barely used our car throughout our stay. We enjoyed almost every element from the fireplaces, to the Jacuzzi tub, to the quaint living room. The only bummer is that you have to purchase your own propane for the fire pit if it’s out. We missed that detail ahead of time and were disappointed when we went out there to read. You guys truly have an incredible space. We will absolutely be back!
Stayed 3 nights in Nov 2025
Verified

10/10 Excellent

Tad C.

Liked: Cleanliness, check-in, communication, location, listing accuracy

great home and location

cool little home and best of all it is walking distance to everything on Main St.
Stayed 2 nights in Jul 2024
Verified

10/10 Excellent

Tracy W.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Such a cute property!

Home is exactly as pictured, cute home, beautifully remodeled. Close to plenty of walking, shopping, and dining. Owners were friendly and quick responders. Will stay again.
Stayed 2 nights in Mar 2025
Verified

10/10 Excellent

Erin W.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Great location!

This home was perfect for a short getaway! It was a great location— just around the corner from the historic main street where we ate and did shopping. We look forward to coming again!
Stayed 2 nights in Jul 2023
Verified

10/10 Excellent

Charles H.

Liked: Cleanliness, check-in, communication, location, listing accuracy

A little bit of history

Accommodations were excellent.. Felt like traveling back in time.
Stayed 2 nights in Apr 2025
Verified

10/10 Excellent

Stephen G.

Liked: Cleanliness, check-in, communication, location, listing accuracy

weekend getaway

awesome property. great location downtown
Stayed 2 nights in Sep 2023
Verified

10/10 Excellent

Amanda D.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Beautiful and perfect location

The attention to detail and history of this property is amazing. Not to meant a fully stocked coffee bar and snacks provided by the owners!! The jetted tub and dual shower was fantastic!!
Stayed 2 nights in Feb 2025
Verified

10/10 Excellent

steve t.

Liked: Cleanliness, check-in, communication, location, listing accuracy

3 day get-away

Property was perfect for my girlfriend and I for a three day get-away.
Stayed 3 nights in Apr 2023
Verified

10/10 Excellent

Andrea E.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Anniversary weekend in St. Charles

Our stay was wonderful! Everything was as it was listed. It was conveniently located and very charming! After a day of walking it was nice to come back and be able to relax. We would definitely stay there again!
Stayed 2 nights in Oct 2024
Verified

10/10 Excellent

Scott B.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Nice all around

Great location and well maintained
Stayed 2 nights in Dec 2020
Verified

10/10 Excellent

Emily S.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Perfect Weekend Getaway

This home was absolutely perfect for us. We stayed here for a few days after our wedding and it was a very romantic. It was very clean and well kept. We would recommend this property 100%
Stayed 3 nights in Aug 2024
Verified

10/10 Excellent

Kristin P.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Valentines Weekend

We enjoyed the cozy space and location that allowed us to have an unplanned weekend of relaxation. We will be back!
Stayed 2 nights in Feb 2025
Verified

10/10 Excellent

Jared E.

Liked: Cleanliness, check-in, communication, location, listing accuracy

A cozy, inviting retreat

My wife and I stayed here for two nights and enjoyed the property and surrounding area so much. The property was so cozy and inviting. We especially loved coming into the warm gas fire after exploring the shops that line the streets of St. Charles.The owners were also a pleasure to work with and they were very accommodating.
Stayed 2 nights in Jan 2025
Verified

10/10 Excellent

Laura M.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Mid Week Anniversary Getaway

We loved our stay! Everything was just as described. Perfect location and easy to work/communicate with. Would definitely recommend and hope to stay again in the future!!
Stayed 3 nights in Jan 2023
Verified

10/10 Excellent

Kayla V.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Amazing

We loved our stay here at The Guest House. The home was beautifully decorated and the location was perfect. Within walking distant to Main St where you will find lots of shopping. Owners responding fed promptly to my messages and referred us to an amazing restaurant, Prasino, to celebrate our anniversary. Although we did not use the back patio, it looked to be a perfect spot to enjoy your morning coffee or relax in the evening. 100% I will stay here again.
Stayed 3 nights in Jun 2025
Verified

10/10 Excellent

Julianna B.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Perfect for couples

Beautiful home. Walked the main street every night. Parking was very easy.
Stayed 3 nights in Jun 2024