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Comfort Inn & Suites Sikeston I-55

2.5 star property

Choose dates to view prices

Photo gallery for Comfort Inn & Suites Sikeston I-55

Exterior
Breakfast area
Desk, free WiFi, bed sheets, alarm clocks
Meeting facility
Lobby

Reviews

8.4 out of 10
Very good

Popular amenities

  • Pet friendly
  • Parking included
  • Free WiFi
  • Air conditioning
  • Gym
The current price is $110
$97 nightly
$110 total
Total with taxes and fees
Jun 28 - Jun 29

Explore the area

View in a map
109 Matthews Ln, Sikeston, MO, 63801
  • Place, City of Miner Convention Center
    ‪5 min walk‬
  • Place, Sikeston Depot Museum
    ‪5 min drive‬
  • Place, Century Casino & Hotel Cape Girardeau
    ‪31 min drive‬
  • Airport, Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
    ‪22 min drive‬

Room options

View all photos for 1 King Bed, Suite, Nonsmoking

Desk, free WiFi, bed sheets, alarm clocks

1 King Bed, Suite, Nonsmoking

  • Sleeps 2
  • Free WiFi

View all photos for 2 Queen Beds, Nonsmoking, Accessible

Desk, free WiFi, bed sheets, alarm clocks

2 Queen Beds, Nonsmoking, Accessible

  • Sleeps 4
  • Free WiFi

View all photos for 1 King Bed, Nonsmoking, Accessible

Desk, free WiFi, bed sheets, alarm clocks

1 King Bed, Nonsmoking, Accessible

  • Sleeps 2
  • Free WiFi

View all photos for Standard Room, 2 Queen Beds, Non Smoking

Standard Room, 2 Queen Beds, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Standard Room, 2 Queen Beds, Non Smoking

8.0 out of 10
Very good
(13 reviews)
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Suite, 1 King Bed with Sofa bed, Non Smoking

Suite, 1 King Bed with Sofa bed, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Suite, 1 King Bed with Sofa bed, Non Smoking

  • 1 bedroom
  • Sleeps 4
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Room, 1 King Bed, Accessible, Non Smoking

Room, 1 King Bed, Accessible, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Room, 1 King Bed, Accessible, Non Smoking

8.6 out of 10
Excellent
(4 reviews)
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Room, 2 Queen Beds, Accessible, Non Smoking

Room, 2 Queen Beds, Accessible, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Room, 2 Queen Beds, Accessible, Non Smoking

10.0 out of 10
Exceptional
(4 reviews)
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Standard Room, 1 King Bed, Non Smoking

Standard Room, 1 King Bed, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Standard Room, 1 King Bed, Non Smoking

8.0 out of 10
Very good
(15 reviews)
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

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Best Western Plus Sikeston I-55
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The price is $104
Jun 14 - Jun 15
Total with taxes and fees
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About the neighborhood

Sikeston

Located in Sikeston, Comfort Inn & Suites Sikeston I-55 is a 1-minute drive from City of Miner Convention Center and 5 minutes from Sikeston Depot Museum. .This hotel is 17.6 mi (28.4 km) from Mississippi River and 3.6 mi (5.8 km) from Central Park.

What's nearby

  • City of Miner Convention Center - 5 min walk - 0.3 miles
  • Central Park - 4 min drive - 3.7 miles
  • Sikeston Depot Museum - 5 min drive - 3.7 miles
  • Southeast Missouri State University - 31 min drive - 38.7 miles
  • Century Casino & Hotel Cape Girardeau - 31 min drive - 38.2 miles

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 29 min drive

Restaurants

  • ‪Lambert's Cafe - ‬17 min walk
  • ‪Buffalo Wild Wings - ‬5 min drive
  • ‪Burger King - ‬4 min drive
  • ‪Imo's Pizza - ‬6 min drive
  • ‪Starbucks - ‬6 min drive

About this property

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55 offers 64 air-conditioned accommodations with coffee/tea makers. Guests can surf the web using the complimentary wireless Internet access.

Bathrooms include bathtubs or showers. Business-friendly amenities include desks and phones.

Recreational amenities at the hotel include an indoor pool and a fitness center.
Make yourself at home in one of the 64 air-conditioned guestrooms. Complimentary wireless internet access is available to keep you connected. Bathrooms with bathtubs or showers are provided. Conveniences include phones, as well as desks and coffee/tea makers.
Don't miss out on recreational opportunities including an indoor pool and a fitness center.
Featured amenities include a business center, a 24-hour front desk, and laundry facilities. Free self parking is available onsite.

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Free self parking on site
  • Wheelchair-accessible parking available

Things to do

  • Gym
  • Indoor pool

Family friendly

  • Indoor pool
  • Laundry facilities

Conveniences

  • 24-hour front desk
  • Laundry facilities
  • Safe at front desk

Business services

  • Business center

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Elevator
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible registration desk

More

  • 3 floors
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided

Bathroom

  • Bathtub or shower
  • Private bathroom
  • Towels provided

Entertainment

  • Cable/satellite channels

Food and drink

  • Coffee/tea maker

More

  • Air conditioning
  • Desk
  • Phone

Policies

Check-in

Check-in start time: 2:00 PM; Check-in end time: anytime
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 20 per pet, per night
Service animals are welcome, and are exempt from fees
Welcoming dogs and cats only
2 total (up to 20 lbs per pet)
Specific rooms only; pet-friendly rooms can be requested by contacting the property at the number on the booking confirmation

Children and extra beds

Children are welcome
Rollaway/extra beds are not available
Cribs (infant beds) are not available

Property payment types

Important information

Optional extras

  • Pet fee: USD 20 per pet, per night
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Choice)

Property is also known as

Comfort Inn Sikeston Hotel
Comfort Inn Sikeston

Comfort Inn & Suites Sikeston I-55 Reviews

Reviews

8.4

Very Good

Rating 10 - Excellent. 141 out of 293 reviews
Rating 8 - Good. 94 out of 293 reviews
Rating 6 - Okay. 29 out of 293 reviews
Rating 4 - Poor. 19 out of 293 reviews
Rating 2 - Terrible. 10 out of 293 reviews

8.4/10

Cleanliness

8.8/10

Staff & service

8.2/10

Amenities

8.2/10

Property conditions & facilities

Reviews

Verified

10/10 Excellent

aileen

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The hotel was very clean, beds were comfortable, and staff was friendly and helpful.
Stayed 1 night in Dec 2025
Verified

10/10 Excellent

Dorothy

facility was very clean. night staff was a pleasure and most helpful. very nice room with lots of space. great stay! good breakfast as well.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Soo

Liked: Cleanliness, staff & service, amenities
Very nice staff & clean room
Stayed 1 night in Dec 2025
Verified

10/10 Excellent

JESSICA

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Connie

Liked: Cleanliness, property conditions & facilities
Room was clean, breakfast was very good.
Stayed 1 night in Nov 2025
Verified

10/10 Excellent

Lisa

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
It was a very nice stay. The pool was clean and enjoying!
Stayed 1 night in Jul 2025
Verified

10/10 Excellent

Jamaal

Liked: Cleanliness, staff & service, amenities
Awesome no complaints
Stayed 2 nights in Nov 2025
Verified

10/10 Excellent

jacqueline

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
It was quiet and peaceful. It was by everything we wanted to go.
Stayed 2 nights in Oct 2025
Verified

8/10 Good

Amanda

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice hotel with great staff. Room was fine, breakfast could be better but overall a good stay for this area.
Verified

10/10 Excellent

Shonta'

Liked: Cleanliness, staff & service, property conditions & facilities
Love Everything
Stayed 4 nights in Oct 2025
Verified

10/10 Excellent

Sasha

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We were happy with our stay
Stayed 1 night in Oct 2024
Verified

10/10 Excellent

Kimberly

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We were in town for a pit-stop to sleep and the staff was very nice. Comfy beds and nice location
Stayed 1 night in Mar 2025
Verified

10/10 Excellent

Shonta'

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The Jacuzzi was the Best!!! 👏
Stayed 6 nights in Oct 2025
Verified

8/10 Good

Walter

Liked: Cleanliness, staff & service, property conditions & facilities
Good place to spend a night
Stayed 1 night in Mar 2025
Verified

10/10 Excellent

Peggy

Liked: Cleanliness, staff & service, property conditions & facilities
The facility was very nice.
Stayed 2 nights in May 2025
Verified

10/10 Excellent

Tammi

Liked: Cleanliness, staff & service, property conditions & facilities
Very clean, nice staff and good breakfast
Stayed 1 night in Aug 2023
Verified

8/10 Good

Denise

hotel was fine clean and convient
Stayed 1 night in Feb 2025
Verified

10/10 Excellent

John

Liked: Cleanliness, staff & service, property conditions & facilities
Great for overnights, staff friendly and attentive
Stayed 1 night in Apr 2024
Verified

10/10 Excellent

Mike

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean, and available rooms when we needed it most due to storms
Stayed 1 night in Feb 2025
Verified

10/10 Excellent

Cindy

Place was great
Stayed 1 night in May 2024
Verified

8/10 Good

John

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Good stay

It was decent…slept well The room was clean
Stayed 1 night in May 2025
Verified

8/10 Good

Dylan

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Right off the main drag, huge complimentary breakfast area
Stayed 1 night in May 2024
Verified

10/10 Excellent

Michael

Liked: Cleanliness, staff & service, property conditions & facilities
Conveniant to I55, clean, and comfortable,
Stayed 1 night in Dec 2024
Verified

8/10 Good

Alan

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The room was chilly. Didn't seem to warm up to our satisfaction.
Stayed 1 night in Nov 2025
Verified

8/10 Good

Willie

Stay was okay but they wouldn't give me a receipt. What's up with that?
Stayed 1 night in Nov 2025