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Hilton Jacksonville At Mayo Clinic

4.5 star property

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Photo gallery for Hilton Jacksonville At Mayo Clinic

Breakfast, lunch, dinner served; American cuisine
Lobby
Terrace/patio
Lake view
Lobby

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pool
  • Parking included
  • Free WiFi
  • Restaurant
  • Air conditioning
  • Gym
$204
$180 nightly
$204 total
Total with taxes and fees
Feb 19 - Feb 20

Explore the area

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4745 Transformation Way, Jacksonville, FL, 32224
  • Place, Mayo Clinic Florida
    ‪1 min walk‬
  • Place, St. Johns Town Center
    ‪7 min drive‬
  • Place, Mayport Naval Station
    ‪17 min drive‬
  • Airport, Jacksonville, FL (JAX-Jacksonville Intl.)
    ‪32 min drive‬

Room options

View all photos for Room, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed

9.0 out of 10
Wonderful
(2 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed (Water View)

View from room

Deluxe Room, 1 King Bed (Water View)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

View from room

Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Corner

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Corner

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Zero Count)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Zero Count)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View)

9.0 out of 10
Wonderful
(2 reviews)
  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View, Roll-In Shower)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Roll-In Shower)

Room, 1 King Bed, Accessible (Roll-In Shower) | Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 2 Queen Beds

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds

10.0 out of 10
Exceptional
(19 reviews)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Water View, Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Water View, Hearing)

  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub

10.0 out of 10
Exceptional
(1 review)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Hearing)

  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds (Water View)

10.0 out of 10
Exceptional
(1 review)
  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub (View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub (View)

  • Sleeps 4
  • 2 Queen Beds

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Sheraton Jacksonville Hotel
  • Pool
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  • Free WiFi
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4.6 out of 5, Wonderful, 1,005 reviews
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The price is $130
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Total with taxes and fees
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About the neighborhood

Jacksonville

With a stay at Hilton Jacksonville At Mayo Clinic in Jacksonville, you'll be a 2-minute drive from Mayo Clinic Florida and 8 minutes from St. Johns Town Center. .This luxury hotel is 10.2 mi (16.5 km) from Mayport Naval Station and 4.6 mi (7.4 km) from University of North Florida.

What's nearby

  • Mayo Clinic Florida - 1 min walk - 0.0 miles
  • University of North Florida - 5 min drive - 5.2 miles
  • St. Johns Town Center - 7 min drive - 6.8 miles
  • TPC Sawgrass - 12 min drive - 9.1 miles
  • Mayport Naval Station - 17 min drive - 11.8 miles

Getting around

  • Jacksonville Station - 28 min drive
  • Jacksonville International Airport (JAX) - 33 min drive

Restaurants

  • ‪Culver’s - ‬3 min drive
  • ‪Starbucks - ‬3 min drive
  • ‪M Brothers at Mayo - ‬14 min walk
  • ‪Circle K - ‬16 min walk
  • ‪Starbucks - ‬13 min walk

About this property

Hilton Jacksonville At Mayo Clinic

Luxury hotel with area shuttle service and a fitness center
Hilton Jacksonville At Mayo Clinic offers 252 air-conditioned accommodations with laptop-compatible safes and complimentary bottled water. Beds feature premium bedding. 55-inch Smart televisions come with premium cable channels and Netflix. Bathrooms include bathtubs or showers and hair dryers.

Guests can surf the web using the complimentary wireless Internet access (speed: 25+ Mbps). Business-friendly amenities include phones; local and long-distance calls are complimentary (restrictions may apply). Additionally, rooms include coffee/tea makers and irons/ironing boards. Housekeeping is provided daily.

Recreational amenities at the hotel include an outdoor pool and a fitness center.

Children under 16 years old are not allowed in the swimming pool without adult supervision. Guests under 16 years old are not allowed in the fitness facility.

Make yourself at home in one of the 252 air-conditioned rooms featuring Smart televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have bathtubs or showers and hair dryers. Conveniences include laptop-compatible safes and coffee/tea makers, as well as phones with free local calls.
Don't miss out on recreational opportunities including an outdoor pool and a fitness center. This hotel also features complimentary wireless internet access, concierge services, and wedding services. Guests can get around on the complimentary shuttle, which operates within 350 yards.
Enjoy American cuisine at Coastal Kitchen, a restaurant which features a bar/lounge, or stay in and take advantage of the room service (during limited hours). Buffet breakfasts are available daily from 6:00 AM to 10:30 AM for a fee.
Featured amenities include express check-out, dry cleaning/laundry services, and a 24-hour front desk. Planning an event in Jacksonville? This hotel has 20000 square feet (1858 square meters) of space consisting of conference space and 12 meeting rooms. Free self parking is available onsite.
Buffet breakfasts are available for a surcharge and are served each morning between 6:00 AM and 10:30 AM.
Coastal Kitchen - This restaurant specializes in American cuisine and serves breakfast, lunch, and dinner. Guests can enjoy drinks at the bar. A children's menu is available.
Coastal Kitchen Bar - Onsite cocktail bar. Open daily.
Late night fare is available from room service (during limited hours).

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • In-room WiFi speed: 25+ Mbps
  • Available in some public areas: Free WiFi

Parking and transportation

  • Electric car charging station on site
  • Free area shuttle up to 350 yds
  • Free uncovered self parking on site

Food and drink

  • Daily buffet breakfast available 6:00 AM to 10:30 AM for a fee: USD 26.99 to 26.99 for adults and USD 15 to 21 for children
  • A bar/lounge
  • A restaurant

Restaurants on site

  • Coastal Kitchen
  • Coastal Kitchen Bar

Things to do

  • Gym
  • Outdoor pool
  • TV in common areas

Family friendly

  • Free area shuttle
  • Grocery/convenience store
  • In-room crib
  • Laundry facilities
  • Mini-fridge
  • Outdoor pool
  • Rollaway/extra bed (surcharge)

Conveniences

  • 24-hour front desk
  • Grocery/convenience store
  • Laundry facilities
  • Luggage storage

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Porter/bellhop
  • Proposal/romance packages
  • Wedding services

Business services

  • 12 meeting rooms
  • 20,000 square feet of conference space
  • Coworking space

Outdoors

  • Firepit
  • Outdoor furniture
  • Pool loungers
  • Pool umbrellas

Accessibility

  • Tile flooring in public areas

More

  • 1 building
  • 8 floors
  • At least 80% lighting from LEDs
  • At least 80% of food locally-sourced
  • Built in 2025
  • Comprehensive food waste policy
  • Smoking not allowed
  • Traditional architecture
  • Vegetarian breakfast available
  • Vegetarian dining options

Room amenities

Bedroom

  • Blackout drapes
  • Free crib
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathtub or shower
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Food and drink

  • Coffee/tea maker
  • Free bottled water
  • Late-night room service
  • Mini-fridge

More

  • Air conditioning
  • Free local calls
  • Free long-distance calls
  • Heating
  • Iron/ironing board
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Water-efficient showers
  • Water-efficient toilets

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 5:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
The credit card used to book the reservation must be presented by the cardholder at check-in along with matching photo identification, and other arrangements must be coordinated with the property prior to arrival
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets not allowed

Children and extra beds

Children are welcome
2 children, per adult, up to the age of 18 years, can stay for free if using existing beds when occupying the parent or guardian's room
Rollaway/extra beds are available for USD 50.00 per night
Free cribs are available on request at the property

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Breakage deposit: USD 100 per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for buffet breakfast: approximately USD 26.99 to 26.99 for adults, and USD 15 to 21 for children
  • Rollaway bed fee: USD 50.00 per night

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards and debit cards; cash is not accepted
This property reserves the right to pre-authorize the guest's credit card prior to arrival.
Cashless transactions are available
Safety features at this property include a carbon monoxide detector and a smoke detector

We should mention

Pool access available from 8:00 AM to 10:00 PM
Only registered guests are allowed in the guestrooms
A car is not required for transportation to and from this property
Guests under 16 years old are not allowed in the fitness facility, and guests under 16 years old are only allowed in the swimming pool with adult supervision
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

Hilton Jacksonville At Mayo Clinic Hotel
Hilton Jacksonville At Mayo Clinic Jacksonville
Hilton Jacksonville At Mayo Clinic Hotel Jacksonville

Hilton Jacksonville At Mayo Clinic Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 97 out of 116 reviews
Rating 8 - Good. 9 out of 116 reviews
Rating 6 - Okay. 4 out of 116 reviews
Rating 4 - Poor. 3 out of 116 reviews
Rating 2 - Terrible. 3 out of 116 reviews

10/10

Cleanliness

9.8/10

Staff & service

9.6/10

Amenities

10/10

Property conditions & facilities

Reviews

10/10 Excellent

Gonzalo

Excellent stay from start to finish. Very nice overall.
Stayed 1 night in Jan 2026

10/10 Excellent

JoAnn

Traveled with family
Liked: Cleanliness, staff & service, amenities
The overall experience was excellent. The room was well maintained and clean. The staff were extremely helpful and accommodating. The experience was so positive that earlier today I booked a stay at a Hilton in the city of a conference I will be attending in the Spring.
Stayed 2 nights in Jan 2026

10/10 Excellent

Schylea

Business traveler, Traveled with family
Liked: Cleanliness, amenities, property conditions & facilities
Clean rooms, friendly staff close to Mayo Clinic.
Stayed 2 nights in Jan 2026

10/10 Excellent

Melody

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Everything was exceptional!
Stayed 2 nights in Jan 2026

10/10 Excellent

Catherine

Business traveler
Liked: Cleanliness, staff & service, amenities
Beautiful hotel! Very comfortable beds. Spotless!! Definitely recommend. A+++++
Stayed 1 night in Jan 2026

10/10 Excellent

Mark

Liked: Cleanliness, staff & service, amenities
Room was spotless, amenities were great, and staff was super nice!
Stayed 5 nights in Dec 2025

10/10 Excellent

Keyante

Business traveler, Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Wonderful shuttle to Mayo!
Stayed 2 nights in Dec 2025

10/10 Excellent

Nancy

Traveled with group, Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Just a short overnight stay to attend NYE event. Spent a short time at the very nice bar. Will stay again.
Stayed 1 night in Dec 2025

10/10 Excellent

Catesha

Liked: Cleanliness, amenities, property conditions & facilities
Very clean
Stayed 1 night in Dec 2025

10/10 Excellent

Julie

Liked: Cleanliness, amenities, property conditions & facilities
Beautiful, clean, great atmosphere, very nice staff!
Stayed 2 nights in Dec 2025

10/10 Excellent

anjillica

Liked: Cleanliness, amenities, property conditions & facilities
Very nice enjoyed visiting
Stayed 1 night in Dec 2025

8/10 Good

Tristan

Liked: Cleanliness, staff & service, amenities
The staff were courteous, the amenities fantastic. Only problem was a clump of hair from a previous guest found in the shower.
Stayed 1 night in Dec 2025

8/10 Good

Lee

Business traveler
Liked: Cleanliness, staff & service, amenities
Clean room.
Stayed 1 night in Dec 2025

8/10 Good

Gregory

Stayed 5 nights in Nov 2025

10/10 Excellent

Adam

Stayed 7 nights in Dec 2025

10/10 Excellent

Adam

Stayed 1 night in Dec 2025

10/10 Excellent

Kelley

Stayed 1 night in Dec 2025

10/10 Excellent

Robert

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Most everything
Stayed 4 nights in Dec 2025

10/10 Excellent

Ricardo

Stayed 1 night in Dec 2025

10/10 Excellent

Stanislav

Liked: Cleanliness, property conditions & facilities
Cleanliness
Stayed 1 night in Dec 2025

10/10 Excellent

DeAnna

Stayed 2 nights in Nov 2025

10/10 Excellent

Jose

Liked: Cleanliness, staff & service, amenities
Staff was courteous. Room was clean and comfortable. Everything looked brand new. Very clean. Beautiful hotel. Will definitely go back.
Stayed 2 nights in Dec 2025

10/10 Excellent

Alan

Stayed 3 nights in Dec 2025

10/10 Excellent

Christy

Liked: Cleanliness, amenities, property conditions & facilities
Staff courteous. Room great
Stayed 1 night in Dec 2025

10/10 Excellent

Sarah

Stayed 1 night in Dec 2025