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Hilton Jacksonville At Mayo Clinic

4.5 star property

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Breakfast, lunch, dinner served; American cuisine
Lake view
Lobby
Lobby
Terrace/patio

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pool
  • Free WiFi
  • Restaurant
  • Air conditioning
  • Gym
  • Breakfast available
$185
$163 nightly
$185 total
Total with taxes and fees
Mar 21 - Mar 22

Explore the area

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4745 Transformation Way, Jacksonville, FL, 32224
  • Place, Mayo Clinic Florida
    ‪1 min walk‬
  • Place, University of North Florida
    ‪6 min drive‬
  • Place, St. Johns Town Center
    ‪8 min drive‬
  • Airport, Jacksonville, FL (JAX-Jacksonville Intl.)
    ‪37 min drive‬

Room options

View all photos for Room, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed

8.0 out of 10
Very good
(3 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed (Water View)

View from room

Deluxe Room, 1 King Bed (Water View)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

View from room

Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Corner

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Corner

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View)

9.0 out of 10
Wonderful
(2 reviews)
  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View, Roll-In Shower)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Roll-In Shower)

Room, 1 King Bed, Accessible (Roll-In Shower) | Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 2 Queen Beds

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds

9.6 out of 10
Exceptional
(21 reviews)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Water View, Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Water View, Hearing)

  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub

10.0 out of 10
Exceptional
(1 review)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Hearing)

8.0 out of 10
Very good
(1 review)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds (Water View)

10.0 out of 10
Exceptional
(1 review)
  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub (View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub (View)

  • Sleeps 4
  • 2 Queen Beds

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The price is $175
Apr 3 - Apr 4
Total with taxes and fees
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About the neighborhood

Jacksonville

With a stay at Hilton Jacksonville At Mayo Clinic in Jacksonville, you'll be a 2-minute drive from Mayo Clinic Florida and 8 minutes from St. Johns Town Center. .This luxury hotel is 10.2 mi (16.5 km) from Mayport Naval Station and 4.6 mi (7.4 km) from University of North Florida.

What's nearby

  • Mayo Clinic Florida - 1 min walk - 0.0 miles
  • University of North Florida - 6 min drive - 5.2 miles
  • St. Johns Town Center - 8 min drive - 7.2 miles
  • TPC Sawgrass - 13 min drive - 9.1 miles
  • Mayport Naval Station - 17 min drive - 11.6 miles

Getting around

  • Jacksonville Station - 28 min drive
  • Jacksonville International Airport (JAX) - 33 min drive

Restaurants

  • ‪Culver’s - ‬3 min drive
  • ‪Starbucks - ‬3 min drive
  • ‪Circle K - ‬16 min walk
  • ‪M Brothers at Mayo - ‬14 min walk
  • ‪Starbucks - ‬13 min walk

About this property

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic offers 252 air-conditioned accommodations with laptop-compatible safes and complimentary bottled water. Beds feature premium bedding. 55-inch Smart televisions come with premium cable channels and Netflix. Bathrooms include bathtubs or showers and hair dryers.

Guests can surf the web using the complimentary wireless Internet access (speed: 25+ Mbps). Business-friendly amenities include phones; local and long-distance calls are complimentary (restrictions may apply). Additionally, rooms include coffee/tea makers and irons/ironing boards. Housekeeping is provided daily.

Recreational amenities at the hotel include an outdoor pool and a fitness center.

Children under 16 years old are not allowed in the swimming pool without adult supervision. Guests under 16 years old are not allowed in the fitness facility.

Make yourself at home in one of the 252 air-conditioned rooms featuring Smart televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have bathtubs or showers and hair dryers. Conveniences include laptop-compatible safes and coffee/tea makers, as well as phones with free local calls.
Don't miss out on recreational opportunities including an outdoor pool and a fitness center. This hotel also features complimentary wireless internet access, concierge services, and wedding services. Guests can get around on the complimentary shuttle, which operates within 350 yards.
Enjoy American cuisine at Coastal Kitchen, a restaurant which features a bar/lounge, or stay in and take advantage of the room service (during limited hours). Buffet breakfasts are available daily from 6:00 AM to 10:30 AM for a fee.
Featured amenities include express check-out, dry cleaning/laundry services, and a 24-hour front desk. Planning an event in Jacksonville? This hotel has 20000 square feet (1858 square meters) of space consisting of conference space and 12 meeting rooms. Free self parking is available onsite.
Buffet breakfasts are available for a surcharge and are served each morning between 6:00 AM and 10:30 AM.
Coastal Kitchen - This restaurant specializes in American cuisine and serves breakfast, lunch, and dinner. Guests can enjoy drinks at the bar. A children's menu is available.
Coastal Kitchen Bar - Onsite cocktail bar. Open daily.
Late night fare is available from room service (during limited hours).

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • In-room WiFi speed: 25+ Mbps
  • Available in some public areas: Free WiFi

Parking and transportation

  • Electric car charging station on site
  • Free area shuttle up to 350 yds
  • Uncovered self parking on site (USD 12 per night)

Food and drink

  • Daily buffet breakfast available 6:00 AM to 10:30 AM for a fee: USD 26.99 to 26.99 for adults and USD 15 to 21 for children
  • A bar/lounge
  • A restaurant

Restaurants on site

  • Coastal Kitchen
  • Coastal Kitchen Bar

Things to do

  • Gym
  • Outdoor pool
  • TV in common areas

Family friendly

  • Free area shuttle
  • Grocery/convenience store
  • In-room crib
  • Laundry facilities
  • Mini-fridge
  • Outdoor pool
  • Rollaway/extra bed (surcharge)

Conveniences

  • 24-hour front desk
  • Grocery/convenience store
  • Laundry facilities
  • Luggage storage

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Porter/bellhop
  • Proposal/romance packages
  • Wedding services

Business services

  • 12 meeting rooms
  • 20,000 square feet of conference space
  • Coworking space

Outdoors

  • Firepit
  • Outdoor furniture
  • Pool loungers
  • Pool umbrellas

Accessibility

  • Tile flooring in public areas

More

  • 1 building
  • 8 floors
  • At least 80% lighting from LEDs
  • At least 80% of food locally-sourced
  • Built in 2025
  • Comprehensive food waste policy
  • Smoking not allowed
  • Traditional architecture
  • Vegetarian breakfast available
  • Vegetarian dining options

Room amenities

Bedroom

  • Blackout drapes
  • Free crib
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathtub or shower
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Food and drink

  • Coffee/tea maker
  • Free bottled water
  • Late-night room service
  • Mini-fridge

More

  • Air conditioning
  • Free local calls
  • Free long-distance calls
  • Heating
  • Iron/ironing board
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Water-efficient showers
  • Water-efficient toilets

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 5:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
The credit card used to book the reservation must be presented by the cardholder at check-in along with matching photo identification, and other arrangements must be coordinated with the property prior to arrival
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets not allowed

Children and extra beds

Children are welcome
2 children, per adult, up to the age of 18 years, can stay for free if using existing beds when occupying the parent or guardian's room
Rollaway/extra beds are available for USD 50.00 per night
Free cribs are available on request at the property

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Breakage deposit: USD 100 per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for buffet breakfast: approximately USD 26.99 to 26.99 for adults, and USD 15 to 21 for children
  • Rollaway bed fee: USD 50.00 per night

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards and debit cards; cash is not accepted
This property reserves the right to pre-authorize the guest's credit card prior to arrival.
Cashless transactions are available
Safety features at this property include a carbon monoxide detector, a fire extinguisher, and a smoke detector

We should mention

Pool access available from 8:00 AM to 10:00 PM
Only registered guests are allowed in the guestrooms
A car is not required for transportation to and from this property
Guests under 16 years old are not allowed in the fitness facility, and guests under 16 years old are only allowed in the swimming pool with adult supervision
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

Hilton Jacksonville At Mayo Clinic Hotel
Hilton Jacksonville At Mayo Clinic Jacksonville
Hilton Jacksonville At Mayo Clinic Hotel Jacksonville

Hilton Jacksonville At Mayo Clinic Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 141 out of 174 reviews
Rating 8 - Good. 15 out of 174 reviews
Rating 6 - Okay. 7 out of 174 reviews
Rating 4 - Poor. 6 out of 174 reviews
Rating 2 - Terrible. 5 out of 174 reviews

9.8/10

Cleanliness

9.6/10

Staff & service

9.4/10

Amenities

10/10

Property conditions & facilities

Reviews

10/10 Excellent

LaCheryl

Business traveler, Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean rooms
Stayed 2 nights in Dec 2025

10/10 Excellent

Edward, Winchester

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great
Stayed 3 nights in Dec 2025

8/10 Good

John

Stayed 5 nights in Dec 2025

6/10 Okay

John

Business traveler, Traveled with family
Liked: Cleanliness, amenities, property conditions & facilities
Very clean nice rooms! Beds are terrible. It’s like someone slept on one side of the bedroom for 20 years without turning the bed….it goes uphill from one side to the other! Very nice room though with great facilities!
Stayed 1 night in Dec 2025

10/10 Excellent

Curtis

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Dec 2025

10/10 Excellent

Mousmee

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
It is a newly built hotel, so rooms wete in good condition. Staff was very friendly and respectful. Id you do not have car, it will be chellenging to go aroubd.
Stayed 3 nights in Nov 2025

10/10 Excellent

Carrie

Business traveler, Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Room was amazing. Staff friendly and very knowledgeable!
Stayed 1 night in Dec 2025

10/10 Excellent

David

Stayed 1 night in Dec 2025

10/10 Excellent

Steven

Business traveler, Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Room with spotless. Staff was courteous. The amenities excellent.
Stayed 1 night in Dec 2025

10/10 Excellent

james

Stayed 2 nights in Dec 2025

8/10 Good

Santiago

It was ok
Stayed 2 nights in Dec 2025

2/10 Terrible

Marckendy

Traveled with partner
Liked: Cleanliness, property conditions & facilities
Disliked: Amenities
Yes the room feel neglected, i caught a cold for sleeping with no heat.i called for help and the staff said the heat will come up itself i spent two night sleeping in the cold i brought a small comforter from Walmart which i forget in the room .0 star
Stayed 2 nights in Dec 2025

10/10 Excellent

Lourdes

Stayed 1 night in Dec 2025

8/10 Good

Judith

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Hotel was lovely and new. Need to address a couple of things. Trash cans too small; no make up mirror in bathroom; no stool or chair in extremely large bath and no hooks for clothes in bathroom.
Stayed 2 nights in Dec 2025

10/10 Excellent

Josel

Stayed 1 night in Nov 2025

10/10 Excellent

Tonya, Bellevue

Stayed 1 night in Nov 2025

10/10 Excellent

Mark

Liked: Cleanliness, staff & service, property conditions & facilities
Clean. Very friendly staff.
Stayed 1 night in Nov 2025

10/10 Excellent

Leroy

Business traveler, Traveled with family
Liked: Cleanliness, amenities, property conditions & facilities
Everything was absolutely amazing. I definitely will be returning as soon as possible.
Stayed 1 night in Nov 2025

8/10 Good

Deborah

Traveled with family
Liked: Cleanliness, property conditions & facilities
Sound of air handler system was loud
Stayed 3 nights in Oct 2025

10/10 Excellent

Deborah

Stayed 2 nights in Nov 2025

10/10 Excellent

Jermaine, panama city

Traveled with group, Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Overall my stay was wonderful. Any concerns that I needed was addressed ASAP. Staff was friendly and helpful. I will stay here again.
Stayed 1 night in Nov 2025

10/10 Excellent

Ruben Dario

Stayed 1 night in Nov 2025

10/10 Excellent

Patty

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful hotel. Close to Mayo Clinic.
Stayed 2 nights in Nov 2025

10/10 Excellent

Kyle

Traveled with partner
Liked: Cleanliness, amenities
Everything in this brand new hotel is Beautifully designed. Elegant. Only complaint is doors slam to rooms!
Stayed 3 nights in Nov 2025

10/10 Excellent

Varun

Traveled with family
Liked: Cleanliness, amenities
Lot of efforts taken to make guests feel special and comfortable. Special thoughts were given to address many minor details. Breakfast had lot of variety and the pool was open till 10 PM. It was perfect for staying during family vacation.
Stayed 3 nights in Nov 2025