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Independent in Cairo

Quality Inn Cairo I-57

13201 Kessler Road Cairo IL

$72 nightly

$80 total

Dec 27 - Dec 28

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

2.7 mi from city center

With a stay at Quality Inn Cairo I-57 in Cairo, you'll be within a 15-minute drive of Mississippi River and Ohio River.

Breakfast included

Pet friendly

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO

$62 nightly

$69 total

Dec 13 - Dec 14

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

10.04 mi from city center

With a stay at Super 8 by Wyndham Charleston/Sikeston East MO, you'll be centrally located in Charleston, 10.3 mi (16.6 km) from Mississippi River and 12.7 mi (20.4 km) from Fort Defiance State Park.

Breakfast included

Pet friendly

Quality Inn Charleston - Sikeston

102 Drake St Charleston MO

$66 nightly

$73 total

Dec 21 - Dec 22

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

11.71 mi from city center

When you stay at Quality Inn Charleston - Sikeston in Charleston, you'll be 13 minutes by car from City of Miner Convention Center.

Breakfast included

Pet friendly

Peaceful secluded cabin located near Horseshoe Lake

Miller City IL

10.85 mi from city center

This cabin is 0.3 mi (0.4 km) from Shawnee National Forest and 6.2 mi (9.9 km) from Ohio River Valley.

Kitchen

Pet friendly

Cozy cabins on beautiful Horseshoe Lake

Olive Branch IL

$133 nightly

$140 total

Dec 22 - Dec 23

Total with taxes and fees

14.88 mi from city center

This cabin is 5.2 mi (8.4 km) from Mississippi River and 0.5 mi (0.8 km) from Shawnee National Forest.

Air conditioning

Lake view

Beer and s'mores anyone? We've got you! Hunting cabin meets weekend hideout.

Tamms IL

17.4 mi from city center

When you stay at this vacation home in Tamms, you'll be steps from Shawnee National Forest.

Kitchen

Washer

Charming cottage overlooking Lake Acre

Dongola IL

$265 nightly

$281 total

Dec 13 - Dec 14

Total with taxes and fees

24.79 mi from city center

Located in Dongola, this cabin is on a lake, within a 15-minute drive of Dongola Lake and Dongola Public Library.

Kitchen

Washer

The Rested Duck Mallard Room

Olive Branch IL

$133 nightly

$140 total

Dec 21 - Dec 22

Total with taxes and fees

14.88 mi from city center

This cabin is 5.2 mi (8.4 km) from Mississippi River and 0.5 mi (0.8 km) from Shawnee National Forest.

Air conditioning

Eagle Inn Charleston

2811 East Marshall Street Charleston MO

$60 nightly

$67 total

Dec 13 - Dec 14

Total with taxes and fees

Free Cancellation

Reserve now, pay when you stay

9.28 mi from city center

With a stay at Eagle Inn Charleston in Charleston, you'll be 10.1 mi (16.3 km) from Mississippi River and 11.7 mi (18.9 km) from Fort Defiance State Park.

Pet friendly

Parking included

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Kevil KY

17.75 mi from city center

With a stay at this vacation home in Kevil, you'll be 16.8 mi (27.1 km) from Mississippi River and 8.3 mi (13.4 km) from Ohio River Valley.

Breakfast included

Kitchen

Beautiful Cabin Retreat

tamms IL

$222 nightly

$235 total

Jan 6 - Jan 7, 2026

Total with taxes and fees

21.95 mi from city center

Located in Tamms, this lodge is in the mountains, within a 15-minute drive of Shawnee National Forest and Ullin City Hall.

Pet friendly

Upscale & Quiet Paducah Retreat on 15 Acres!

West Paducah KY

20.46 mi from city center

Located in West Paducah, this cottage is within a 15-minute drive of Paul Rowton Indoor Tennis Center and Lone Oak Tennis Center.

Kitchen

Washer

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Cairo hotels essential information

Accommodation	25 hotels
Lowest Price	$67
Highest Price	$281
Popular hotels	Quality Inn Cairo I-57, Super 8 by Wyndham Charleston/Sikeston East MO, Quality Inn Charleston - Sikeston, Peaceful secluded cabin located near Horseshoe Lake , Cozy cabins on beautiful Horseshoe Lake, Beer and s'mores anyone? We've got you! Hunting cabin meets weekend hideout., Charming cottage overlooking Lake Acre, The Rested Duck Mallard Room, Eagle Inn Charleston, Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286, Beautiful Cabin Retreat, Upscale & Quiet Paducah Retreat on 15 Acres!