Santee Vacation Rentals

Get more for your budget and save up to 50% off select Secret Bargain hotels

Get even more value with CheapTickets Price Guarantee!

Change your flight without a fee on select flights

Vacation Rentals in Santee

Beautiful Cottage between Lake Moultrie and Lake Marion

Cross SC

Located in Cross, this vacation home is on the waterfront, within a 15-minute drive of Lake Marion and Angel's Landing Marina.

Deep water Lake Marion house. 4BR 2.5BA. Fish off dock. Nearby Golf. SUNSETS

Summerton SC

Located in Summerton, this vacation home is on the waterfront, within a 15-minute drive of Lake Marion and Pine Island.

Luxury 4-Bedroom Lake Marion Retreat w/ Rooftop Deck & Spacious Outdoor Living

Manning SC

$487 nightly

$541 total

Oct 20 - Oct 21

Total with taxes and fees

Located in Manning, this vacation home is on a lake, a 1-minute drive from Lake Marion and 10 minutes from Wyboo Golf Club.

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Santee SC

$334 nightly

$371 total

Sep 27 - Sep 28

Total with taxes and fees

With a stay at this vacation home in Santee, you'll be on a lake, just steps from Lake Marion and a 4-minute drive from Santee Cooper Country Club.

Lake Marion's Big Red House. W/ Dock and Kayaks. Pet Friendly please read policy

Manning SC

Located in Manning, this vacation home is on the waterfront, within a 15-minute drive of Lake Marion and Wyboo Golf Club.

SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable

Summerton SC

When you stay at this vacation home in Summerton, you'll be on the beach and steps from Lake Marion.

Lake Marion Lakehouse with 180° lake view

Elloree SC

Located in Elloree, this vacation home is on the waterfront, within a 15-minute drive of Lake Marion and Orangeburg County Library Mentor Branch.

Beautiful Lake Marion Views!! Pet Friendly! Newly renovated and updated!!

Summerton SC

With a stay at this vacation home in Summerton, you'll be on the waterfront, just steps from Lake Marion and a 3-minute drive from Goat Island.

Cozy Home with Private Boat Landing

Summerton SC

With a stay at this vacation home in Summerton, you'll be on the waterfront, just steps from Lake Marion and a 4-minute drive from Goat Island.

Beautiful lake home to make your family vacation extra special!

Summerton SC

When you stay at this vacation home in Summerton, you'll be 4 minutes by foot from Lake Marion.

Relax by Lake Marion - A lake home with you in mind.

Eutawville SC

When you stay at this vacation home in Eutawville, you'll be on the waterfront and steps from Lake Marion.

Tie One On! at 4 Bdr Waterfront Lake Marion

Manning SC

Located in Manning, this vacation home is a 1-minute drive from Lake Marion and 10 minutes from Wyboo Golf Club.

Don't see what you're looking for?

See all available properties in Santee

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.