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21c Museum Hotel Louisville

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Front of property
Fountain
Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe
Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe
Breakfast, lunch and dinner served
Luxury
4.5 star property
9.4

Exceptional

Art museum meets boutique retreat

Acclaimed restaurant Proof on Main serves phenomenal cuisine in an artsy atmosphere connected to the hotel's museum gallery. Guests can retreat to the full-service spa for rejuvenating massages. The downtown Louisville location puts museums, bourbon tours, and attractions within walking distance.

Popular amenities

  • Spa
  • Pet friendly
  • Free WiFi
  • Air conditioning
  • Gym
The current price is $184
$156 nightly
$184 total
Total with taxes and fees
May 25 - May 26

Explore the area

View in a map
700 W Main Street, Louisville, KY, 40202
  • Place, 21c Museum Hotel
    ‪1 min walk‬
  • Place, Louisville Slugger Museum
    ‪3 min walk‬
  • Place, KFC Yum Center
    ‪8 min walk‬
  • Airport, Louisville, KY (SDF-Louisville Intl.)
    ‪10 min drive‬

Room options

View all photos for Deluxe Double Room, 2 Double Beds

Deluxe Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Deluxe Double Room, 2 Double Beds

9.6 out of 10
Exceptional
(31 reviews)
  • 335 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds

View all photos for Luxury Double Room, 2 Double Beds

Luxury Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Luxury Double Room, 2 Double Beds

9.0 out of 10
Wonderful
(2 reviews)
  • City view
  • 435 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed

9.6 out of 10
Exceptional
(71 reviews)
  • 350 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed

View all photos for Luxury Room, 1 King Bed

Luxury Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Luxury Room, 1 King Bed

9.2 out of 10
Wonderful
(35 reviews)
  • City view
  • 455 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed

View all photos for Suite, Corner

Suite, Corner | Premium bedding, down comforters, minibar, in-room safe

Suite, Corner

  • City view
  • 660 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Room (Asleep in the Cyclone)

Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe

Room (Asleep in the Cyclone)

  • 500 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Suite (Atrium)

Suite (Atrium) | Premium bedding, down comforters, minibar, in-room safe

Suite (Atrium)

  • 580 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Room, Balcony

Room, Balcony | Premium bedding, down comforters, minibar, in-room safe

Room, Balcony

10.0 out of 10
Exceptional
(1 review)
  • City view
  • 315 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Double Room, Accessible

Designer toiletries, hair dryer, bathrobes, towels

Deluxe Double Room, Accessible

9.0 out of 10
Wonderful
(2 reviews)
  • 455 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

10.0 out of 10
Exceptional
(2 reviews)
  • 434 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

10.0 out of 10
Exceptional
(1 review)
  • 435 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Apartment, 1 Double Bed (Rooftop)

Apartment, 1 Double Bed (Rooftop) | Premium bedding, down comforters, minibar, in-room safe

Apartment, 1 Double Bed (Rooftop)

  • City view
  • Sleeps 4
  • 1 Double Bed

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About the neighborhood

Louisville

With a stay at 21c Museum Hotel Louisville, you'll be centrally located in Louisville, steps from Louisville Slugger Museum and 8 minutes by foot from Kentucky International Convention Center. .This luxury hotel is 0.4 mi (0.7 km) from KFC Yum Center and 6.8 mi (10.9 km) from Kentucky Exposition Center.

What's nearby

  • 21c Museum Hotel - 1 min walk - 0.0 miles
  • Muhammad Ali Center - 3 min walk - 0.2 miles
  • Louisville Slugger Museum - 3 min walk - 0.2 miles
  • Kentucky International Convention Center - 8 min walk - 0.5 miles
  • KFC Yum Center - 8 min walk - 0.5 miles

Getting around

  • Louisville Intl. Airport (SDF) - 10 min drive

Restaurants

  • ‪Jockey Silks Bourbon Bar - ‬7 min walk
  • ‪Heine Brothers' Coffee - ‬3 min walk
  • ‪Swizzle - ‬8 min walk
  • ‪Vincenzo's Italian Restaurant - ‬5 min walk
  • ‪Mussel & Burger Bar - ‬1 min walk

About this property

21c Museum Hotel Louisville

21c Museum Hotel Louisville offers 91 accommodations with minibars and laptop-compatible safes. Beds feature down comforters and premium bedding. 50-inch LCD televisions come with premium cable channels. Bathrooms include bathrobes, designer toiletries, complimentary toiletries, and hair dryers.

This Louisville hotel provides complimentary wired and wireless Internet access. Business-friendly amenities include desks along with free local calls (restrictions may apply). Additionally, rooms include espresso makers and complimentary bottled water. In-room massages and hypo-allergenic bedding can be requested. Housekeeping is provided daily.

Recreational amenities at the hotel include a 24-hour fitness center.

The recreational activities listed below are available either on site or nearby; fees may apply.

21c Spa has 2 treatment rooms. Services include deep-tissue massages, hot stone massages, sports massages, and Swedish massages. The spa is equipped with a sauna and a steam room. The spa is open daily.
Make yourself at home in one of the 91 guestrooms featuring iPod docking stations and minibars. Your bed comes with down comforters and premium bedding. Wired and wireless internet access is complimentary, while 50-inch LCD televisions with cable programming provide entertainment. Private bathrooms have designer toiletries and hair dryers.
Relax at the full-service spa, where you can enjoy massages. Additional features at this hotel include complimentary wireless internet access, concierge services, and gift shops/newsstands.
Grab a bite to eat at Proof on Main, a fine-dining restaurant which features a bar/lounge, or stay in and take advantage of the room service (during limited hours). Full breakfasts are served on weekdays from 7:00 AM to 10:00 AM and on weekends from 8:00 AM to 1:00 PM for a fee.
Featured amenities include complimentary wired internet access, a 24-hour business center, and limo/town car service. Planning an event in Louisville? This hotel has 5000 square feet (465 square meters) of space consisting of conference space and meeting rooms.
Full breakfasts are available for a surcharge on weekdays between 7:00 AM and 10:00 AM and on weekends between 8:00 AM and 1:00 PM.
Proof on Main - This fine-dining restaurant serves breakfast, brunch, lunch, and dinner. Guests can enjoy drinks at the bar.
Room service (during limited hours) is available.

Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Electric car charging station on site
  • Limo/town car service
  • Valet parking on site (USD 32 per night; includes in/out privileges)
  • Wheelchair-accessible parking available

Food and drink

  • Full breakfast available for a fee 7:00 AM to 10:00 AM on weekdays and 8:00 AM to 1:00 PM on weekends; USD 5 to 25 per person
  • A bar/lounge
  • A restaurant
  • Coffee and tea in common areas

Restaurants on site

  • Proof on Main

Things to do

  • 24-hour gym
  • Full-service spa
  • Yoga classes

Family friendly

  • In-room crib
  • Laundry facilities
  • Rollaway/extra bed (surcharge)
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Gift shop/newsstand
  • Laundry facilities
  • Luggage storage
  • Safe at front desk

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Multilingual staff
  • Porter/bellhop
  • Tour and ticket assistance

Business services

  • 24-hour business center
  • 5,000 square feet of conference space
  • Computer station
  • Meeting rooms

Full-service spa

  • 2 treatment rooms
  • Deep-tissue massages
  • Hot stone massages
  • In-room massages
  • Prenatal massages
  • Sauna
  • Spa open daily
  • Sports massages
  • Steam room
  • Swedish massages

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Elevator
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible registration desk

More

  • 1 building
  • 4 floors
  • At least 80% lighting from LEDs
  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • Built in 2006
  • Comprehensive food waste policy
  • Double-glazed windows
  • Eco-friendly cleaning products used
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed
  • Vegan dining options

Room amenities

Bedroom

  • Blackout drapes
  • Down comforter
  • Free crib
  • Hypo-allergenic bedding
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathrobes
  • Designer toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • 50-inch LCD TV with premium cable channels
  • iPod dock

Food and drink

  • Champagne service
  • Espresso maker
  • Free bottled water
  • Limited room service
  • Minibar

More

  • Air conditioning (climate-controlled)
  • Cleaning products are eco-friendly
  • Connecting rooms available
  • Desk
  • Eco-friendly toiletries
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Soundproofed rooms
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4 PM; Check-in end time: midnight
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 40.00 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Up to 50 lbs per pet
Food and water bowls are available

Children and extra beds

Children are welcome
Rollaway/extra beds are available for USD 30.0 per night
Free cribs are available on request at the property

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5.00 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for full breakfast: approximately USD 5 to 25 per person
  • Valet parking fee: USD 32 per night (in/out privileges)
  • Pet fee: USD 40.00 per accommodation, per stay
  • Service animals are exempt from fees
  • Rollaway bed fee: USD 30.0 per night

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards; cash is not accepted
This property uses eco-friendly cleaning products
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels)

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

21c Hotel Louisville
21c Hotel Museum
21c Louisville Hotel
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Louisville 21c Hotel
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21c Museum Hotel Louisville Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 778 out of 1002 reviews
Rating 8 - Good. 127 out of 1002 reviews
Rating 6 - Okay. 60 out of 1002 reviews
Rating 4 - Poor. 20 out of 1002 reviews
Rating 2 - Terrible. 17 out of 1002 reviews

9.6/10

Cleanliness

9.4/10

Staff & service

9.0/10

Amenities

9.6/10

Property conditions & facilities

Reviews

10/10 Excellent

Lee Anne

Traveled with family
Liked: Cleanliness, amenities, property conditions & facilities
Really interesting setting for a hotel with all of the artwork. The room was clean and comfortable. We would have appreciated softer towels.
Stayed 2 nights in Jan 2026

10/10 Excellent

Laura

Traveled with family
Liked: Cleanliness, amenities, property conditions & facilities
Staff was fantastic. Room was clean and bed was very comfortable. Great temperature control. Excellent location.
Stayed 1 night in Jan 2026

10/10 Excellent

Jeannie

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Clean room, art work is beautiful, friendly staff .
Stayed 1 night in Jan 2026

10/10 Excellent

JEFF

Traveled with group
Liked: Cleanliness, amenities, property conditions & facilities
Fantastic, caring staff in an artsy and fun environment.
Stayed 2 nights in Jan 2026

10/10 Excellent

Lisa

Stayed 1 night in Jan 2026

8/10 Good

Xiaohong

Traveled with family
Liked: Cleanliness, amenities, property conditions & facilities
The hotel is quite distinctive. It is an art gallery itself. But you may not appreciate the work itself.
Stayed 1 night in Jan 2026

10/10 Excellent

Amy

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities
Great location. Not your typical hotel decor!
Stayed 2 nights in Jan 2026

8/10 Good

Stacy

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Great location for Whiskey Row in Downtown Louisville. Hotel was clean, artsy and has a great restaurant on site.
Stayed 2 nights in Jan 2026

10/10 Excellent

Artem

Stayed 1 night in Jan 2026

10/10 Excellent

Jeffrey

Stayed 2 nights in Jan 2026

10/10 Excellent

Joseph

Stayed 2 nights in Jan 2026

10/10 Excellent

graham

Stayed 1 night in Jan 2026

10/10 Excellent

Cheryl

Stayed 1 night in Jan 2026

10/10 Excellent

Barbara

Traveled with family
Liked: Cleanliness, amenities, property conditions & facilities
Staff very helpful. Rooms are spacious and clean. Lobby exhibits unique and interesting. Hotel well situated in downtown to access popular tourist attractions. Enjoyed our stay.
Stayed 3 nights in Jan 2026

10/10 Excellent

Madeline

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Location and the staff was fabulous.
Stayed 2 nights in Jan 2026

10/10 Excellent

Justin

Stayed 1 night in Jan 2026

10/10 Excellent

Karen

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Fun hotel, lots of interesting art, very comfortable, excellent staff
Stayed 2 nights in Jan 2026

10/10 Excellent

Murray

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Dec 2025

10/10 Excellent

steven

Liked: Cleanliness, staff & service, amenities
Art gallery was amazing
Stayed 1 night in Dec 2025

10/10 Excellent

DONALD, Louisville

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Attractive, comfortable rooms are as nice as any in the downtown area. On Museum Row, close to Lou Slugger Museum, Frazier History Museum. 10 min. walk to Bourbon Row. On site rest. very good, but pricy. Would definitely stay again. Ten, of course!
Stayed 2 nights in Jan 2026

10/10 Excellent

Brian, Dakota Dunes

Stayed 1 night in Jan 2026

10/10 Excellent

Morgan

Stayed 1 night in Jan 2026

10/10 Excellent

Lorie

Liked: Cleanliness, staff & service, amenities
All the staff were great! The rooms were clean the coffee was great. I would stay here again.
Stayed 2 nights in Jan 2026

10/10 Excellent

Frank

Stayed 1 night in Jan 2026

6/10 Okay

Carol

Traveled with partner
Liked: Cleanliness
Disliked: Amenities, property conditions & facilities
The bed was comfortable.The art exhibits were closed down. I wish I'd known beforehand as I probably wouldn't have booked. The shower gel dispenser was empty. Just not what I had expected from a boutique hotel.
Stayed 1 night in Jan 2026