Lowest round trip fares by airline from Orlando and San Francisco

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Cheap flights from Orlando to San Francisco

Cheap flights from Orlando to San Francisco

Your flight from Orlando International Airport (MCO) to San Francisco International Airport (SFO), will bring you to the exciting City by the Bay. From Chinatown and the Castro, to Haight-Ashbury and Telegraph Hill, San Francisco is made up of exciting and varied neighborhoods. At SFO, renting a vehicle is a cinch. In a little more than an hour, you can take your rental car down to San Jose via Interstate 280.

Key Facts

In San Francisco, the only major interstate is I-280, which runs east to west. State Highway 101 runs through the city from north to south and connects to most of the major roadways. The observation deck at Coit Tower is a great place to view the city, from the wharf to the Golden Gate Bridge.

For some fresh air, you can visit Pier 39. After walking down the length of the pier and enjoying a little window shopping, you can visit the sea lions that enjoy catching some rays on the rocks nearby. You’ll also find some amazing views of the boats sailing by on the bay.

Hints and Tips

After boarding your airplane at the Orlando International Airport (MCO), you can expect to spend more than five hours in the air before arriving in San Francisco.

Packages from Orlando to San Francisco

Hotels in San Francisco

See all 464 Hotels in San Francisco
Stanford Court San Francisco
Stanford Court San Francisco
905 California Street, San Francisco
4.0 out of 5.0
4.5 out of 5 (26 reviews)

Guests can indulge in high-end shops like Prada and Tiffany & Co at Union Square, 4 blocks away. Chinatown is 5 minutes on foot, and the American Conservatory ...

$149

$149
The Westin St Francis San Francisco on Union Square
The Westin St Francis San Francisco on Union Square
335 Powell Street, San Francisco
4.0 out of 5.0
4.3 out of 5 (30 reviews)

This elegant and historic 1904 hotel offers a prime location across from San Francisco's Union Square; cable cars stop right at the front door, and the Financial ...

$205

$205
Pullman San Francisco Bay
Pullman San Francisco Bay
223 Twin Dolphin Dr, Redwood City
4.0 out of 5.0
3.8 out of 5 (8 reviews)

Set along a tranquil lagoon, this contemporary resort-style hotel is 11 miles south of San Francisco International Airport and an equidistant 25 miles from San ...

$104

$104
San Francisco Marriott Marquis
San Francisco Marriott Marquis
780 Mission Street, San Francisco
4.0 out of 5.0
4.3 out of 5 (20 reviews)

The San Francisco Marriott Marquis is steps from Union Square shopping, Chinatown, cable cars, and the San Francisco Museum of Modern Art.

$151

$151
Hotel Zephyr
Hotel Zephyr
250 Beach Street, San Francisco
3.5 out of 5.0
4.0 out of 5 (3 reviews)

This family-friendly San Francisco hotel is located on the waterfront, within a 5-minute walk of Wax Museum at Fisherman's Wharf, Fisherman's Wharf, and Pier ...

$179

$179
Sheraton Fisherman's Wharf Hotel
Sheraton Fisherman's Wharf Hotel
2500 Mason St, San Francisco
4.0 out of 5.0
4.0 out of 5 (22 reviews)

This smoke-free San Francisco Sheraton is within 2 blocks of the cable car turnaround and Pier 39, 5 blocks from Ghirardelli Square, and within 1 mile of Lombard ...

$127

$127
Serrano Hotel
Serrano Hotel
405 Taylor St, San Francisco
4.0 out of 5.0
4.0 out of 5 (4 reviews)

The Serrano Hotel is steps away from Union Square, perfectly positioned in the Theater District of San Francisco, 2 blocks from the Powell Street cable car.

$153

$153
The Tuscan, A Noble House Hotel
The Tuscan, A Noble House Hotel
425 North Point, San Francisco
4.0 out of 5.0
3.6 out of 5 (17 reviews)

The Tuscan, A Noble House Hotel is 2 blocks from Fisherman's Wharf, Pier 39, and the Alcatraz Island ferry.

$186

$186
Hyatt Regency San Francisco
Hyatt Regency San Francisco
5 Embarcadero Center, San Francisco
4.0 out of 5.0
4.4 out of 5 (14 reviews)

The 17-story Hyatt Regency is located on the Embarcadero waterfront, across from the Ferry Building Marketplace, close to the Embarcadero Center, Union Square, ...

$199

$199
Hotel Whitcomb
Hotel Whitcomb
1231 Market St, San Francisco
3.5 out of 5.0
3.5 out of 5 (77 reviews)

Located in the San Francisco theater district with a BART and MUNI station at its entrance, this downtown hotel is 6 blocks from Union Square and within a mile ...

$132

$132
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Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.