Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Lowest round trip fares by airline from Orlando and San Francisco

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Cheap flights from Orlando to San Francisco

Cheap flights from Orlando to San Francisco

Your flight from Orlando International Airport (MCO) to San Francisco International Airport (SFO), will bring you to the exciting City by the Bay. From Chinatown and the Castro, to Haight-Ashbury and Telegraph Hill, San Francisco is made up of exciting and varied neighborhoods. At SFO, renting a vehicle is a cinch. In a little more than an hour, you can take your rental car down to San Jose via Interstate 280.

Key Facts

In San Francisco, the only major interstate is I-280, which runs east to west. State Highway 101 runs through the city from north to south and connects to most of the major roadways. The observation deck at Coit Tower is a great place to view the city, from the wharf to the Golden Gate Bridge.

For some fresh air, you can visit Pier 39. After walking down the length of the pier and enjoying a little window shopping, you can visit the sea lions that enjoy catching some rays on the rocks nearby. You’ll also find some amazing views of the boats sailing by on the bay.

Hints and Tips

After boarding your airplane at the Orlando International Airport (MCO), you can expect to spend more than five hours in the air before arriving in San Francisco.

Packages from Orlando to San Francisco

Hotels in San Francisco

See all 522 Hotels in San Francisco
Hotel Zoe San Francisco

Hotel Zoe San Francisco

425 North Point, San Francisco
4.5 out of 5.0
3.7 out of 5 (22 reviews)

Hotel Zoe San Francisco is 2 blocks from Fisherman's Wharf, Pier 39, and the Alcatraz Island ferry.

$149

$149
Pier 2620 Hotel Fisherman's Wharf

Pier 2620 Hotel Fisherman's Wharf

2620 Jones Street, San Francisco
4.5 out of 5.0
4.3 out of 5 (32 reviews)

Located in North Beach, this hotel is within a 10-minute walk of Powell and Market Cable Car Turnaround, Fishermans Wharf Cable Car Turnaround, and Hyde Street ...

$161

$161
Fairmont San Francisco

Fairmont San Francisco

950 Mason Street Atop Nob Hill, San Francisco
3.7 out of 5 (13 reviews)

Fairmont San Francisco is located atop swanky Nob Hill, the only spot in the city where every cable car line intersects. Guests can hop a ride past the Cable ...

$199

$199
Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco

2 New Montgomery St, San Francisco
5.0 out of 5.0
4.1 out of 5 (10 reviews)

A member of The Luxury Collection of Starwood Hotels and Resorts, this legendary 1909 hotel in downtown San Francisco is 1 block from the Financial District, ...

$167

$167
Hilton San Francisco Union Square

Hilton San Francisco Union Square

333 O'Farrell St., San Francisco
4.5 out of 5.0
4.0 out of 5 (51 reviews)

Iconic, AAA 4-Diamond hotel a few steps from Union Square, Cable Car station, theatre district, BART, Chinatown, SFMOMA, and Moscone Center. Upgraded rooms offer ...

$128

$128
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
4.0 out of 5.0
3.5 out of 5 (84 reviews)

Located in the San Francisco theater district with a BART and MUNI station at its entrance, this downtown hotel is 6 blocks from Union Square and within a mile ...

$105

$105
The Park Central San Francisco

The Park Central San Francisco

50 3rd St, San Francisco
4.5 out of 5.0
4.5 out of 5 (15 reviews)

Located in the heart of the South of Market district (SoMa), The Park Central San Francisco is across from Yerba Buena Gardens and close to the San Francisco ...

$113

$113
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

433 Powell St, San Francisco
3.5 out of 5.0
4.4 out of 5 (7 reviews)

This historic 15-story hotel is on San Francisco's Powell Street Cable Car line. Union Square, Moscone Center, Chinatown, TransAmerica Tower, the Financial District, ...

$107

$107
Holiday Inn San Francisco-Fisherman's Wharf

Holiday Inn San Francisco-Fisherman's Wharf

1300 Columbus Ave, San Francisco
4.0 out of 5.0
3.8 out of 5 (51 reviews)

Located just 1 mile from Union Square, this Holiday Inn is within 2 blocks of Fisherman's Wharf and Ghirardelli Square.

$112

$112
Hyatt Regency San Francisco Airport

Hyatt Regency San Francisco Airport

1333 Bayshore Hwy, Burlingame
4.5 out of 5.0
4.2 out of 5 (21 reviews)

Built around a skylit open atrium, this 9-story hotel on San Francisco Bay features an onsite restaurant and is located 2.5 miles from the airport, 10 miles ...

$99

$99
Map

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other CheapTickets users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $75 service fee charged by CheapTickets.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.