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Cheap flights from Orlando (ORL) to San Francisco (QSF)

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Lowest round trip fares by airline from Orlando and San Francisco

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Cheap flights from Orlando to San Francisco

Cheap flights from Orlando to San Francisco

Your flight from Orlando International Airport (MCO) to San Francisco International Airport (SFO), will bring you to the exciting City by the Bay. From Chinatown and the Castro, to Haight-Ashbury and Telegraph Hill, San Francisco is made up of exciting and varied neighborhoods. At SFO, renting a vehicle is a cinch. In a little more than an hour, you can take your rental car down to San Jose via Interstate 280.

Key Facts

In San Francisco, the only major interstate is I-280, which runs east to west. State Highway 101 runs through the city from north to south and connects to most of the major roadways. The observation deck at Coit Tower is a great place to view the city, from the wharf to the Golden Gate Bridge.

For some fresh air, you can visit Pier 39. After walking down the length of the pier and enjoying a little window shopping, you can visit the sea lions that enjoy catching some rays on the rocks nearby. You’ll also find some amazing views of the boats sailing by on the bay.

Hints and Tips

After boarding your airplane at the Orlando International Airport (MCO), you can expect to spend more than five hours in the air before arriving in San Francisco.

Packages from Orlando to San Francisco

Hotels in San Francisco

See all 528 Hotels in San Francisco
Handlery Union Square Hotel

Handlery Union Square Hotel

351 Geary St, San Francisco
3.5 out of 5.0
4.0 out of 5 (52 reviews)

A half-block from cable cars, this hotel is 2 blocks from Westfield San Francisco Shopping Centre; the Moscone Center and the San Francisco Museum of Modern ...

$169

$169
Serrano Hotel

Serrano Hotel

405 Taylor St, San Francisco
4.0 out of 5.0
3.4 out of 5 (7 reviews)

The Serrano Hotel is steps away from Union Square, perfectly positioned in the Theater District of San Francisco, 2 blocks from the Powell Street cable car.

$168

$168
Hilton San Francisco Union Square

Hilton San Francisco Union Square

333 O'Farrell St., San Francisco
4.0 out of 5.0
4.0 out of 5 (48 reviews)

Iconic, AAA 4-Diamond hotel a few steps from Union Square, Cable Car station, theatre district, BART, Chinatown, SFMOMA, and Moscone Center. Upgraded rooms offer ...

$179

$179
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
3.5 out of 5.0
3.5 out of 5 (79 reviews)

Located in the San Francisco theater district with a BART and MUNI station at its entrance, this downtown hotel is 6 blocks from Union Square and within a mile ...

$135

$135
Villa Florence

Villa Florence

225 Powell St, San Francisco
4.0 out of 5.0
4.2 out of 5 (11 reviews)

Infused with the spirit of Italy, this romantic downtown San Francisco retreat is on the Powell Street cable car line, less than a block from Union Square; theaters ...

$140

$140
Hyatt Regency San Francisco Airport

Hyatt Regency San Francisco Airport

1333 Bayshore Hwy, Burlingame
4.0 out of 5.0
4.2 out of 5 (20 reviews)

Built around a skylit open atrium, this fully renovated 9-story hotel on San Francisco Bay features an onsite restaurant and is located 2.5 miles from the airport, ...

$139

$139
Pier 2620 Hotel Fisherman's Wharf

Pier 2620 Hotel Fisherman's Wharf

2620 Jones Street, San Francisco
3.5 out of 5.0
4.2 out of 5 (23 reviews)

Located in North Beach, this hotel is within a 10-minute walk of Ripley's Believe It Or Not Museum, Wax Museum at Fisherman's Wharf, and Ghirardelli Square. ...

$246

$246
Grand Hyatt San Francisco Union Square

Grand Hyatt San Francisco Union Square

345 Stockton St, San Francisco
4.0 out of 5.0
3.9 out of 5 (26 reviews)

Rising 36 stories above Union Square, this sleek, contemporary hotel is 1 block from cable cars, 3 blocks from Westfield San Francisco Centre shopping mall, ...

$189

$189
Travelodge San Francisco Airport-North

Travelodge San Francisco Airport-North

326 S Airport Blvd, South San Francisco
2.0 out of 5.0
2.7 out of 5 (72 reviews)

This 200-room hotel is 2 miles north of San Francisco International Airport and 10 miles from downtown San Francisco.

$93

$93
Sweden House Hotel

Sweden House Hotel

570 O'farrell St, San Francisco
2.5 out of 5.0
1.2 out of 5 (4 reviews)

Located in Downtown San Francisco, this hotel is within a 10-minute walk of Bohemian Club, Union Square, and Westfield San Francisco Centre. Asian Art Museum ...

$76

$76
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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other CheapTickets users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $75 service fee charged by CheapTickets.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.