Lowest round trip fares by airline from Orlando and San Francisco

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Cheap flights from Orlando to San Francisco

Cheap flights from Orlando to San Francisco

Your flight from Orlando International Airport (MCO) to San Francisco International Airport (SFO), will bring you to the exciting City by the Bay. From Chinatown and the Castro, to Haight-Ashbury and Telegraph Hill, San Francisco is made up of exciting and varied neighborhoods. At SFO, renting a vehicle is a cinch. In a little more than an hour, you can take your rental car down to San Jose via Interstate 280.

Key Facts

In San Francisco, the only major interstate is I-280, which runs east to west. State Highway 101 runs through the city from north to south and connects to most of the major roadways. The observation deck at Coit Tower is a great place to view the city, from the wharf to the Golden Gate Bridge.

For some fresh air, you can visit Pier 39. After walking down the length of the pier and enjoying a little window shopping, you can visit the sea lions that enjoy catching some rays on the rocks nearby. You’ll also find some amazing views of the boats sailing by on the bay.

Hints and Tips

After boarding your airplane at the Orlando International Airport (MCO), you can expect to spend more than five hours in the air before arriving in San Francisco.

Packages from Orlando to San Francisco

Hotels in San Francisco

See all 424 Hotels in San Francisco
Pier 2620 Hotel Fisherman's Wharf
Pier 2620 Hotel Fisherman's Wharf
2620 Jones Street, San Francisco
3.5 out of 5.0
4.1 out of 5 (21 reviews)

Located in North Beach, this hotel is within a 10-minute walk of Ripley's Believe It Or Not Museum, Wax Museum at Fisherman's Wharf, and Ghirardelli Square. ...

$169

$169
Stanford Court San Francisco
Stanford Court San Francisco
905 California Street, San Francisco
4.0 out of 5.0
4.5 out of 5 (26 reviews)

Guests can indulge in high-end shops like Prada and Tiffany & Co at Union Square, 4 blocks away. Chinatown is 5 minutes on foot, and the American Conservatory ...

$150

$150
Hotel Zephyr
Hotel Zephyr
250 Beach Street, San Francisco
3.5 out of 5.0
4.0 out of 5 (3 reviews)

This family-friendly San Francisco hotel is located on the waterfront, within a 5-minute walk of Wax Museum at Fisherman's Wharf, Fisherman's Wharf, and Pier ...

$188

$188
The Westin St Francis San Francisco on Union Square
The Westin St Francis San Francisco on Union Square
335 Powell Street, San Francisco
4.0 out of 5.0
4.3 out of 5 (30 reviews)

This elegant and historic 1904 hotel offers a prime location across from San Francisco's Union Square; cable cars stop right at the front door, and the Financial ...

$250

$250
The Tuscan, A Noble House Hotel
The Tuscan, A Noble House Hotel
425 North Point, San Francisco
4.0 out of 5.0
3.6 out of 5 (18 reviews)

The Tuscan, A Noble House Hotel is 2 blocks from Fisherman's Wharf, Pier 39, and the Alcatraz Island ferry.

$239

$239
Handlery Union Square Hotel
Handlery Union Square Hotel
351 Geary St, San Francisco
3.5 out of 5.0
4.0 out of 5 (52 reviews)

A half-block from cable cars, this hotel is 2 blocks from Westfield San Francisco Shopping Centre; the Moscone Center and the San Francisco Museum of Modern ...

$139

$139
Serrano Hotel
Serrano Hotel
405 Taylor St, San Francisco
4.0 out of 5.0
4.0 out of 5 (4 reviews)

The Serrano Hotel is steps away from Union Square, perfectly positioned in the Theater District of San Francisco, 2 blocks from the Powell Street cable car.

$143

$143
Hotel Whitcomb
Hotel Whitcomb
1231 Market St, San Francisco
3.5 out of 5.0
3.5 out of 5 (77 reviews)

Located in the San Francisco theater district with a BART and MUNI station at its entrance, this downtown hotel is 6 blocks from Union Square and within a mile ...

$116

$116
Omni San Francisco Hotel
Omni San Francisco Hotel
500 California St, San Francisco
4.5 out of 5.0

Located at the base of Nob Hill, Omni San Francisco Hotel is a 13-minute walk from Union Square. The Embarcadero Center, BART Station, and North Beach are within ...

$229

$229
Hyatt Regency San Francisco
Hyatt Regency San Francisco
5 Embarcadero Center, San Francisco
4.0 out of 5.0
4.4 out of 5 (14 reviews)

The 17-story Hyatt Regency is located on the Embarcadero waterfront, across from the Ferry Building Marketplace, close to the Embarcadero Center, Union Square, ...

$179

$179
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