Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Lowest round trip fares by airline from Orlando and San Francisco

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Cheap flights from Orlando to San Francisco

Cheap flights from Orlando to San Francisco

Your flight from Orlando International Airport (MCO) to San Francisco International Airport (SFO), will bring you to the exciting City by the Bay. From Chinatown and the Castro, to Haight-Ashbury and Telegraph Hill, San Francisco is made up of exciting and varied neighborhoods. At SFO, renting a vehicle is a cinch. In a little more than an hour, you can take your rental car down to San Jose via Interstate 280.

Key Facts

In San Francisco, the only major interstate is I-280, which runs east to west. State Highway 101 runs through the city from north to south and connects to most of the major roadways. The observation deck at Coit Tower is a great place to view the city, from the wharf to the Golden Gate Bridge.

For some fresh air, you can visit Pier 39. After walking down the length of the pier and enjoying a little window shopping, you can visit the sea lions that enjoy catching some rays on the rocks nearby. You’ll also find some amazing views of the boats sailing by on the bay.

Hints and Tips

After boarding your airplane at the Orlando International Airport (MCO), you can expect to spend more than five hours in the air before arriving in San Francisco.

Packages from Orlando to San Francisco

Hotels in San Francisco

See all 496 Hotels in San Francisco
Hotel Nikko San Francisco

Hotel Nikko San Francisco

222 Mason St, San Francisco
    4.0 out of 5.0
     
     
    4.2 out of 5 (39 reviews)

    The Asian-inspired Hotel Nikko San Francisco is located downtown, a 4-minute walk from Union Square and the designer shops of Westfield San Francisco Centre. ...

    Hotel Nikko San Francisco$166

    Hotel Nikko San Francisco$166
    The Westin St. Francis San Francisco on Union Square

    The Westin St. Francis San Francisco on Union Square

    335 Powell Street, San Francisco
      4.0 out of 5.0
       
       
      4.3 out of 5 (35 reviews)

      This elegant and historic 1904 hotel offers a prime location across from San Francisco's Union Square; cable cars stop right at the front door, and the Financial ...

      The Westin St. Francis San Francisco on Union Square$157

      The Westin St. Francis San Francisco on Union Square$157
      Hotel Whitcomb

      Hotel Whitcomb

      1231 Market St, San Francisco
        3.5 out of 5.0
         
         
        3.5 out of 5 (89 reviews)

        Located in the San Francisco theater district with a BART and MUNI station at its entrance, this downtown hotel is 6 blocks from Union Square and within a mile ...

        Hotel Whitcomb$115

        Hotel Whitcomb$115
        San Francisco Marriott Marquis

        San Francisco Marriott Marquis

        780 Mission Street, San Francisco
          4.0 out of 5.0
           
           
          4.3 out of 5 (28 reviews)

          The San Francisco Marriott Marquis is steps from Union Square shopping, Chinatown, cable cars, and the San Francisco Museum of Modern Art.

          San Francisco Marriott Marquis$159

          San Francisco Marriott Marquis$159
          Travelodge by Wyndham San Francisco Airport North

          Travelodge by Wyndham San Francisco Airport North

          326 S Airport Blvd, South San Francisco
            2.0 out of 5.0
             
             
            2.7 out of 5 (81 reviews)

            This 200-room hotel is 2 miles north of San Francisco International Airport and 10 miles from downtown San Francisco.

            Travelodge by Wyndham San Francisco Airport North$67

            Travelodge by Wyndham San Francisco Airport North$67
            Villa Florence San Francisco on Union Square

            Villa Florence San Francisco on Union Square

            225 Powell St, San Francisco
              4.0 out of 5.0
               
               
              4.1 out of 5 (14 reviews)

              Infused with the spirit of Italy, this romantic downtown San Francisco retreat is on the Powell Street cable car line, less than a block from Union Square; theaters ...

              Villa Florence San Francisco on Union Square$143

              Villa Florence San Francisco on Union Square$143
              Stanford Court San Francisco

              Stanford Court San Francisco

              905 California Street, San Francisco
                4.0 out of 5.0
                 
                 
                4.3 out of 5 (30 reviews)

                Nob Hill area

                Stanford Court San Francisco$117

                Stanford Court San Francisco$117
                Pier 2620 Hotel Fisherman's Wharf

                Pier 2620 Hotel Fisherman's Wharf

                2620 Jones Street, San Francisco
                  4.0 out of 5.0
                   
                   
                  4.3 out of 5 (34 reviews)

                  Located in North Beach, this hotel is within a 10-minute walk of Fishermans Wharf Cable Car Turnaround, Hyde Street Pier, and Ghirardelli Square. Lombard Street ...

                  Pier 2620 Hotel Fisherman's Wharf$152

                  Pier 2620 Hotel Fisherman's Wharf$152
                  The Park Central San Francisco

                  The Park Central San Francisco

                  50 3rd St, San Francisco
                    4.0 out of 5.0
                     
                     
                    4.5 out of 5 (15 reviews)

                    Located in the heart of the South of Market district (SoMa), The Park Central San Francisco is across from Yerba Buena Gardens and close to the San Francisco ...

                    The Park Central San Francisco$112

                    The Park Central San Francisco$112
                    Sweden House Hotel

                    Sweden House Hotel

                    570 O'farrell St, San Francisco
                      2.5 out of 5.0
                       
                       
                      1.0 out of 5 (3 reviews)

                      Located in Downtown San Francisco, this hotel is within a 10-minute walk of Westfield San Francisco Centre and Asian Art Museum of San Francisco. San Francisco ...

                      Sweden House Hotel$70

                      Sweden House Hotel$70
                      Map

                      Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other CheapTickets users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

                      Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $75 service fee charged by CheapTickets.

                      Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.