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Lowest round trip fares by airline from Orlando and San Francisco

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Cheap flights from Orlando to San Francisco

Cheap flights from Orlando to San Francisco

Your flight from Orlando International Airport (MCO) to San Francisco International Airport (SFO), will bring you to the exciting City by the Bay. From Chinatown and the Castro, to Haight-Ashbury and Telegraph Hill, San Francisco is made up of exciting and varied neighborhoods. At SFO, renting a vehicle is a cinch. In a little more than an hour, you can take your rental car down to San Jose via Interstate 280.

Key Facts

In San Francisco, the only major interstate is I-280, which runs east to west. State Highway 101 runs through the city from north to south and connects to most of the major roadways. The observation deck at Coit Tower is a great place to view the city, from the wharf to the Golden Gate Bridge.

For some fresh air, you can visit Pier 39. After walking down the length of the pier and enjoying a little window shopping, you can visit the sea lions that enjoy catching some rays on the rocks nearby. You’ll also find some amazing views of the boats sailing by on the bay.

Hints and Tips

After boarding your airplane at the Orlando International Airport (MCO), you can expect to spend more than five hours in the air before arriving in San Francisco.

Packages from Orlando to San Francisco

Hotels in San Francisco

See all 521 Hotels in San Francisco
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
3.5 out of 5.0
3.5 out of 5 (83 reviews)

Located in the San Francisco theater district with a BART and MUNI station at its entrance, this downtown hotel is 6 blocks from Union Square and within a mile ...

$149

$149
Hotel Zoe San Francisco

Hotel Zoe San Francisco

425 North Point, San Francisco
4.0 out of 5.0
3.7 out of 5 (22 reviews)

Hotel Zoe San Francisco is 2 blocks from Fisherman's Wharf, Pier 39, and the Alcatraz Island ferry.

$209

$209
Travelodge San Francisco Airport-North

Travelodge San Francisco Airport-North

326 S Airport Blvd, South San Francisco
2.0 out of 5.0
2.7 out of 5 (75 reviews)

This 200-room hotel is 2 miles north of San Francisco International Airport and 10 miles from downtown San Francisco.

$76

$76
Hilton San Francisco Downtown/Financial District

Hilton San Francisco Downtown/Financial District

750 Kearny St, San Francisco
4.0 out of 5.0
4.0 out of 5 (14 reviews)

This 27-story San Francisco Hilton hotel towers over the city's financial district, North Beach's Italian shops and cafés, Chinatown, and the Embarcadero ...

$188

$188
A Secluded Home Just Outside Of San Francisco And Close To Airport & Bart

A Secluded Home Just Outside Of San Francisco And Close To Airport & Bart

250 Thiers St, Daly City

Situated in Daly City, this vacation home is 2.4 mi (3.9 km) from City College of San Francisco and 2.5 mi (4 km) from San Francisco State University. University ...

Hotel Nikko San Francisco

Hotel Nikko San Francisco

222 Mason St, San Francisco
4.0 out of 5.0
4.2 out of 5 (39 reviews)

The Asian-inspired Hotel Nikko San Francisco is located downtown, a 4-minute walk from Union Square and the designer shops of Westfield San Francisco Centre. ...

$232

$232
Serrano Hotel

Serrano Hotel

405 Taylor St, San Francisco
4.0 out of 5.0
3.4 out of 5 (7 reviews)

The Serrano Hotel is steps away from Union Square, perfectly positioned in the Theater District of San Francisco, 2 blocks from the Powell Street cable car.

$178

$178
Hotel Zephyr

Hotel Zephyr

250 Beach Street, San Francisco
3.5 out of 5.0
3.8 out of 5 (6 reviews)

This family-friendly San Francisco hotel is located on the waterfront, within a 5-minute walk of Wax Museum at Fisherman's Wharf, Pier 39, and Ripley's Believe ...

$169

$169
Pier 2620 Hotel Fisherman's Wharf

Pier 2620 Hotel Fisherman's Wharf

2620 Jones Street, San Francisco
3.5 out of 5.0
4.2 out of 5 (29 reviews)

Located in North Beach, this hotel is within a 10-minute walk of Fishermans Wharf Cable Car Turnaround, Hyde Street Pier, and Ghirardelli Square. Lombard Street ...

$178

$178
The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

335 Powell Street, San Francisco
4.0 out of 5.0
4.3 out of 5 (33 reviews)

This elegant and historic 1904 hotel offers a prime location across from San Francisco's Union Square; cable cars stop right at the front door, and the Financial ...

$249

$249
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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other CheapTickets users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $75 service fee charged by CheapTickets.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.